More than One Way to Skin a Wound.

Abstract:

:Large cutaneous and non-healing ulcers exhibit impaired epithelialization, which represents a major therapeutic challenge. Recently in Nature, Kurita et al. (2018) reported a surprising potential source of epithelial cells. The authors demonstrate that wound-resident mesenchymal cells can be reprogrammed to generate expandable epithelial tissues and facilitate wound closure.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Ankawa R,Fuchs Y

doi

10.1016/j.stem.2018.10.014

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

636-638

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(18)30495-8

journal_volume

23

pub_type

评论,杂志文章
  • A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.

    abstract::While gene expression dynamics have been extensively cataloged during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and post-transcriptional changes in HSCs during development, we leve...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.03.012

    authors: Cesana M,Guo MH,Cacchiarelli D,Wahlster L,Barragan J,Doulatov S,Vo LT,Salvatori B,Trapnell C,Clement K,Cahan P,Tsanov KM,Sousa PM,Tazon-Vega B,Bolondi A,Giorgi FM,Califano A,Rinn JL,Meissner A,Hirschhorn JN,Daley

    更新日期:2018-04-05 00:00:00

  • Position statement on the provision and procurement of human eggs for stem cell research.

    abstract::The nature of compensation for women who donate eggs (oocytes) for research remains a contentious issue internationally. This position paper lays out the arguments for, and discusses the arrangements in which, a modest payment might be ethically justifiable. ...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2013.02.002

    authors: Haimes E,Skene L,Ballantyne AJ,Caulfield T,Goldstein LS,Hyun I,Kimmelman J,Robert JS,Roxland BE,Scott CT,Solbakk JH,Sugarman J,Taylor PL,Testa G,ISSCR.

    更新日期:2013-03-07 00:00:00

  • The race for regeneration: Pluripotent-stem-cell-derived 3D kidney structures.

    abstract::The kidney's complex spatial organization and poorly defined lineage specification programs have impeded derivation of kidney progenitors from pluripotent stem cells (PSCs). Now in Cell Stem Cell, Taguchi et al. (2014) redefine the identity of embryonic kidney progenitors in vivo to obtain PSC-derived kidney progenito...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2013.12.004

    authors: Gouon-Evans V

    更新日期:2014-01-02 00:00:00

  • Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs.

    abstract::Combination of stem cell-based approaches with gene-editing technologies represents an attractive strategy for studying human disease and developing therapies. However, gene-editing methodologies described to date for human cells suffer from technical limitations including limited target gene size, low targeting effic...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2011.04.019

    authors: Liu GH,Suzuki K,Qu J,Sancho-Martinez I,Yi F,Li M,Kumar S,Nivet E,Kim J,Soligalla RD,Dubova I,Goebl A,Plongthongkum N,Fung HL,Zhang K,Loring JF,Laurent LC,Izpisua Belmonte JC

    更新日期:2011-06-03 00:00:00

  • Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

    abstract::Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding sequences. To investi...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2017.07.008

    authors: Forrest MP,Zhang H,Moy W,McGowan H,Leites C,Dionisio LE,Xu Z,Shi J,Sanders AR,Greenleaf WJ,Cowan CA,Pang ZP,Gejman PV,Penzes P,Duan J

    更新日期:2017-09-07 00:00:00

  • FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.

    abstract::Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.05.027

    authors: Chu SH,Heiser D,Li L,Kaplan I,Collector M,Huso D,Sharkis SJ,Civin C,Small D

    更新日期:2012-09-07 00:00:00

  • Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.

    abstract::To assess the genetic consequences of induced pluripotent stem cell (iPSC) reprogramming, we sequenced the genomes of ten murine iPSC clones derived from three independent reprogramming experiments, and compared them to their parental cell genomes. We detected hundreds of single nucleotide variants (SNVs) in every clo...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.03.002

    authors: Young MA,Larson DE,Sun CW,George DR,Ding L,Miller CA,Lin L,Pawlik KM,Chen K,Fan X,Schmidt H,Kalicki-Veizer J,Cook LL,Swift GW,Demeter RT,Wendl MC,Sands MS,Mardis ER,Wilson RK,Townes TM,Ley TJ

    更新日期:2012-05-04 00:00:00

  • A 3D Tissue-wide Digital Imaging Pipeline for Quantitation of Secreted Molecules Shows Absence of CXCL12 Gradients in Bone Marrow.

    abstract::Technological limitations have hampered understanding of how individual molecules, including putative stem cell regulators, are distributed throughout tissues and stem cell niches. Here, we report adaptation of the proximity ligation assay (PLA) for large-volume, in situ imaging of individual proteins with multiple ad...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.10.003

    authors: Kunz L,Schroeder T

    更新日期:2019-12-05 00:00:00

  • Cellular reprogramming in pursuit of immortality.

    abstract::The discovery that phenotypic diversity among differentiated cells results from epigenetic and not genetic differences, and can be reset to restore pluripotency, promises revolutionary advances in medicine. I discuss how this and related seminal discoveries have brought us to an exciting future. ...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.11.014

    authors: Surani MA

    更新日期:2012-12-07 00:00:00

  • Pluripotency on Lockdown after Deletion of Three Transcription Regulators.

    abstract::Exit from the naive pluripotent state occurs through a series of changes in the gene regulatory circuitry, allowing cells to become primed for lineage commitment. In this issue of Cell Stem Cell, Kalkan et al. (2019) show that three transcription regulators are required for naive mouse embryonic stem cells (ESCs) to e...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2019.04.008

    authors: Mitchell JA

    更新日期:2019-05-02 00:00:00

  • Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.

    abstract::Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here ...

    journal_title:Cell stem cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.stem.2015.05.002

    authors: Adams PD,Jasper H,Rudolph KL

    更新日期:2015-06-04 00:00:00

  • Profiling identifies precursor suspects: notch family again!

    abstract::Newborn neurons in the adult dentate gyrus pass through several distinct precursor and progenitor classes prior to differentiation. In this issue of Cell Stem Cell, Lugert et al. (2010) characterized their strikingly different proliferative behaviors after neurogenic stimuli or aging. ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2010.04.006

    authors: Breunig JJ,Rakic P

    更新日期:2010-05-07 00:00:00

  • 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.

    abstract::Pluripotent stem cells (PSCs) could provide a powerful system to model development of the human esophagus, whose distinct tissue organization compared to rodent esophagus suggests that developmental mechanisms may not be conserved between species. We therefore established an efficient protocol for generating esophagea...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.08.009

    authors: Zhang Y,Yang Y,Jiang M,Huang SX,Zhang W,Al Alam D,Danopoulos S,Mori M,Chen YW,Balasubramanian R,Chuva de Sousa Lopes SM,Serra C,Bialecka M,Kim E,Lin S,Toste de Carvalho ALR,Riccio PN,Cardoso WV,Zhang X,Snoeck HW,Q

    更新日期:2018-10-04 00:00:00

  • Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.

    abstract::Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated with tyrosine kinase inhibitors (TKIs). TKIs do not eliminate disease-propagating leukemic stem cells (LSCs), suggesting a deeper understandi...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.02.018

    authors: Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R

    更新日期:2019-05-02 00:00:00

  • Control of stem cell fate by physical interactions with the extracellular matrix.

    abstract::A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at th...

    journal_title:Cell stem cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.stem.2009.06.016

    authors: Guilak F,Cohen DM,Estes BT,Gimble JM,Liedtke W,Chen CS

    更新日期:2009-07-02 00:00:00

  • Gut with the Program: Direct Reprogramming toward Intestinal Epithelium Realized.

    abstract::Intestinal organoids offer great promise for modeling intestinal diseases; however, harvesting intestinal tissue is invasive and directed hPSC differentiation protocols are laborious and costly. In this issue of Cell Stem Cell, Miura and Suzuki (2017) describe the direct conversion of somatic cells from both mice and ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2017.09.011

    authors: Nakauka-Ddamba A,Lengner CJ

    更新日期:2017-10-05 00:00:00

  • Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.

    abstract::The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular pathways essential for brain development and autoph...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2016.07.019

    authors: Liang Q,Luo Z,Zeng J,Chen W,Foo SS,Lee SA,Ge J,Wang S,Goldman SA,Zlokovic BV,Zhao Z,Jung JU

    更新日期:2016-11-03 00:00:00

  • Stem cells go soft: pliant substrate surfaces enhance motor neuron differentiation.

    abstract::Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cy...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2014.05.007

    authors: Wang N

    更新日期:2014-06-05 00:00:00

  • Metabolic regulation of hematopoietic stem cells in the hypoxic niche.

    abstract::Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaer...

    journal_title:Cell stem cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.stem.2011.09.010

    authors: Suda T,Takubo K,Semenza GL

    更新日期:2011-10-04 00:00:00

  • Correction of a genetic disease in mouse via use of CRISPR-Cas9.

    abstract::The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2013.10.016

    authors: Wu Y,Liang D,Wang Y,Bai M,Tang W,Bao S,Yan Z,Li D,Li J

    更新日期:2013-12-05 00:00:00

  • Out of Many, One: Computational Reconstruction of Mouse Skin using Single-Cell Transcriptomics.

    abstract::Mammalian skin is a complex and heterogeneous tissue with several distinct compartments and stem cell populations. Joost et al. (2016) now use single-cell RNaseq to comprehensively reconstruct this complexity, revealing spatial and pseudotemporal differences between transcriptional programs in distinct compartments an...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2016.09.009

    authors: Chen JC,Christiano AM

    更新日期:2016-10-06 00:00:00

  • Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

    abstract::Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescen...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.12.011

    authors: Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA

    更新日期:2020-03-05 00:00:00

  • Self-Organizing 3D Human Trunk Neuromuscular Organoids.

    abstract::Neuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neurons or skeletal muscles in monolayer culture. Here, we use hPSC-deriv...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.12.007

    authors: Faustino Martins JM,Fischer C,Urzi A,Vidal R,Kunz S,Ruffault PL,Kabuss L,Hube I,Gazzerro E,Birchmeier C,Spuler S,Sauer S,Gouti M

    更新日期:2020-02-06 00:00:00

  • A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

    abstract::Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique subtypes are urgently needed for precision medicine development. Here, we have established a primary gastric cancer organoid (GCO) biobank that comprises norma...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.09.016

    authors: Yan HHN,Siu HC,Law S,Ho SL,Yue SSK,Tsui WY,Chan D,Chan AS,Ma S,Lam KO,Bartfeld S,Man AHY,Lee BCH,Chan ASY,Wong JWH,Cheng PSW,Chan AKW,Zhang J,Shi J,Fan X,Kwong DLW,Mak TW,Yuen ST,Clevers H,Leung SY

    更新日期:2018-12-06 00:00:00

  • Autoimmune T cells lured to a FASL web of death by MSCs.

    abstract::Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2012.04.013

    authors: Murphy WJ,Nolta JA

    更新日期:2012-05-04 00:00:00

  • Close Quarters Can Be a Good Fit for Stem Cells to Become T Cells.

    abstract::Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hematopoietic differentia...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2019.02.013

    authors: Trotman-Grant A,Zúñiga-Pflücker JC

    更新日期:2019-03-07 00:00:00

  • A scientist's view of the ethics of human embryonic stem cell research.

    abstract::Scientists are rarely immoral and seldom even amoral. The ethical principles that underlie much of their own work are shared with scientists in other countries to a much greater degree than the cultural and religious differences among those countries would lead one to expect. Like me, few will have had any formal trai...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2007.05.003

    authors: McLaren A

    更新日期:2007-06-07 00:00:00

  • Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

    abstract::Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various therapeutic and research applications. However, several problems remain for t...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2008.10.004

    authors: Shi Y,Desponts C,Do JT,Hahm HS,Schöler HR,Ding S

    更新日期:2008-11-06 00:00:00

  • Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs.

    abstract::Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets d...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2015.04.009

    authors: Bogdanović O,Lister R

    更新日期:2015-05-07 00:00:00

  • Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells.

    abstract::Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to ...

    journal_title:Cell stem cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.stem.2009.03.005

    authors: Feng B,Ng JH,Heng JC,Ng HH

    更新日期:2009-04-03 00:00:00