Abstract：
:Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested that ESCs and iPSCs represent different pluripotent states with substantially different gene expression profiles. We describe here a comparison of global chromatin structure and gene expression data for a panel of human ESCs and iPSCs. Genome-wide maps of nucleosomes with histone H3K4me3 and H3K27me3 modifications indicate that there is little difference between ESCs and iPSCs with respect to these marks. Gene expression profiles confirm that the transcriptional programs of ESCs and iPSCs show very few consistent differences. Although some variation in chromatin structure and gene expression was observed in these cell lines, these variations did not serve to distinguish ESCs from iPSCs.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Guenther MG,Frampton GM,Soldner F,Hockemeyer D,Mitalipova M,Jaenisch R,Young RAdoi
10.1016/j.stem.2010.06.015subject
Has Abstractpub_date
2010-08-06 00:00:00pages
249-57issue
2eissn
1934-5909issn
1875-9777pii
S1934-5909(10)00330-9journal_volume
7pub_type
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