Abstract：
:Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to address DNA damage, and describe how these mechanisms can impact SC genomic integrity by potentially promoting aging, tissue atrophy, and/or cancer development. Finally, we will discuss how similar mechanisms operate in cancer stem cells (CSCs) and can mediate resistance to chemo- and radiotherapy.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Blanpain C,Mohrin M,Sotiropoulou PA,Passegué Edoi
10.1016/j.stem.2010.12.012subject
Has Abstractpub_date
2011-01-07 00:00:00pages
16-29issue
1eissn
1934-5909issn
1875-9777pii
S1934-5909(10)00707-1journal_volume
8pub_type
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