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Notch one up to stroma: endothelial notch prevents inflammation and myeloproliferation.

Abstract：

:In this issue of Cell Stem Cell, Wang et al. (2014) describe a signaling axis present in bone marrow stromal cells that suppresses inflammation and myeloid expansions. Loss of endothelial Notch signaling leads to deregulation of miR-155 expression, activation of NF-kB, and increased proinflammatory cytokine production, which promotes a myeloproliferative phenotype.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Khalaj M,Park CY

doi

10.1016/j.stem.2014.06.010

subject

Has Abstract

pub_date

2014-07-03 00:00:00

pages

1-2

issue

1

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(14)00258-6

journal_volume

15

pub_type

评论,杂志文章

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