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Young and Restless: Expansion of Donor-Origin Mutant HSCs after Transplantation.

Abstract：

:In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-derived leukemia was not observed.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Steensma DP

doi

10.1016/j.stem.2020.01.022

subject

Has Abstract

pub_date

2020-03-05 00:00:00

pages

305-306

issue

3

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(20)30052-7

journal_volume

26

pub_type

评论,杂志文章

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