Abstract:
:Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML. We generated Tspan3 knockout mice that were born without overt defects. However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML. Additionally, Tspan3 inhibition blocked growth of AML patient samples, suggesting that Tspan3 is also important in human disease. As part of the mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in AML localization within the niche. These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Kwon HY,Bajaj J,Ito T,Blevins A,Konuma T,Weeks J,Lytle NK,Koechlein CS,Rizzieri D,Chuah C,Oehler VG,Sasik R,Hardiman G,Reya Tdoi
10.1016/j.stem.2015.06.006subject
Has Abstractpub_date
2015-08-06 00:00:00pages
152-164issue
2eissn
1934-5909issn
1875-9777journal_volume
17pub_type
杂志文章相关文献
Cell Stem Cell文献大全abstract::Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mic...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2008.01.012
更新日期:2008-02-07 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem cells (iPSCs) via exogenous transcription factors but the underlying mechanism is unclear. Here we show that the generation of iPSCs fro...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.04.014
更新日期:2010-07-02 00:00:00
abstract::Secreted frizzled-related protein 1 (Sfrp1) is highly expressed by stromal cells maintaining hematopoietic stem cells (HSCs). Sfrp1 loss in stromal cells increases production of hematopoietic progenitors, and in knockout mice, dysregulates hemostasis and increases Flk2- Cd34- Lin- Sca1+ Kit+ (LSK) cell numbers in bone...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.05.020
更新日期:2009-08-07 00:00:00
abstract::Sox family transcription factors have emerged as key regulators of multiple developmental processes, including fate determination and differentiation in multiple tissues. In this issue of Cell Stem Cell, Nowak et al. (2008) implicate Sox9 in the specification of early hair follicle stem cells and subsequent epithelial...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2008.06.014
更新日期:2008-07-03 00:00:00
abstract::In injured tissues, regeneration is often associated with cell fate plasticity, in that cells deviate from their normal lineage paths. It is becoming increasingly clear that this plasticity often creates alternative strategies to restore damaged or lost cells. Alternatively, cell fate plasticity is also part and parce...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2018.05.009
更新日期:2018-09-06 00:00:00
abstract::Embryonic stem cells (ESCs) are an attractive source for tissue regeneration and repair therapies because they can be differentiated into virtually any cell type in the adult body. However, for this approach to succeed, the transplanted ESCs must survive long enough to generate a therapeutic benefit. A major obstacle ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.01.012
更新日期:2011-03-04 00:00:00
abstract::Inducing immune tolerance to prevent rejection is a key step toward successful engraftment of stem-cell-derived tissue in a clinical setting. Using human pluripotent stem cells to generate thymic epithelial cells (TECs) capable of supporting T cell development represents a promising approach to reach this goal; howeve...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.04.004
更新日期:2013-08-01 00:00:00
abstract::Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcript...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2019.09.007
更新日期:2019-10-03 00:00:00
abstract::Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy m...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2018.08.010
更新日期:2018-09-06 00:00:00
abstract::In this issue of Cell Stem Cell, Palii et al. reveal that TAL1 is a master regulator of adhesion and migration networks in human endothelial progenitors and that ex vivo treatment with the histone deacetylase inhibitor TSA enables their faster vascularization after ischemic injury. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.04.018
更新日期:2014-05-01 00:00:00
abstract::Steroid hormones are known systemic regulators of multiple normal and cancerous tissues; however, whether or how they impact the fate and function of adult stem cells is unclear. In the Drosophila ovary, insulin signals modulate the proliferation and self-renewal of germline stem cells (GSCs), yet despite evidence tha...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.10.001
更新日期:2010-11-05 00:00:00
abstract::In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cyc...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2018.12.005
更新日期:2019-01-03 00:00:00
abstract::Neurons derived from human pluripotent stem cells (hPSCs) are powerful tools for studying human neural development and diseases. Robust functional coupling of hPSC-derived neurons with target tissues in vitro is essential for modeling intercellular physiology in a dish and to further translational studies, but it has ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.05.002
更新日期:2016-07-07 00:00:00
abstract::New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ul...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.12.003
更新日期:2017-01-05 00:00:00
abstract::In a recent issue of Nature, Tachibana et al. (2009) conducted chromosomal transfer into recipient primate oocytes to yield live offspring or monkey ESCs with no contribution of donor mitochondria. The success of this technique may increase demand for human oocyte donation for research. ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.09.009
更新日期:2009-10-02 00:00:00
abstract::The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting co...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.10.002
更新日期:2013-11-07 00:00:00
abstract::Erythropoietin, the red blood cell-making cytokine, is also a potential cytoprotective agent in heart disease. In this issue of Cell Stem Cell, Hoch et al. (2011) use two heart failure models, including chemotherapeutic cardiotoxicity, to reveal a mechanistic connection between reduced cardiomyocyte production of eryt...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2011.07.008
更新日期:2011-08-05 00:00:00
abstract:VIDEO ABSTRACT:Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.03.016
更新日期:2012-07-06 00:00:00
abstract::Recently in Cell, Mitalipov and colleagues report an advance that has eluded scientists for over a decade-the successful derivation of embryonic stem cell lines using somatic cell nuclear transfer, or SCNT (Tachibana et al., 2013). ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2013.05.022
更新日期:2013-06-06 00:00:00
abstract::N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be frequently deleted, implying a ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.04.009
更新日期:2020-07-02 00:00:00
abstract::Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). However, this process is typically very inefficient, complicating mechanistic studies. We identified and molecularly characterized rare, early intermediates poised to reprogram with up to 95% efficiency, without perturbin...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.06.013
更新日期:2018-08-02 00:00:00
abstract::Cells of adult mammals can be converted (reprogrammed) to new cells. In one approach, adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate new cell types. Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these ...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2008.09.015
更新日期:2008-10-09 00:00:00
abstract::Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2019.05.009
更新日期:2019-06-06 00:00:00
abstract::The kidney's complex spatial organization and poorly defined lineage specification programs have impeded derivation of kidney progenitors from pluripotent stem cells (PSCs). Now in Cell Stem Cell, Taguchi et al. (2014) redefine the identity of embryonic kidney progenitors in vivo to obtain PSC-derived kidney progenito...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2013.12.004
更新日期:2014-01-02 00:00:00
abstract::In this issue of Cell Stem Cell, Belema-Bedada et al. (2008) describe a novel mechanism by which bone marrow-derived adult mesenchymal stem cells migrate to sites of damaged heart tissue. This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2. ...
journal_title:Cell stem cell
pub_type: 评论
doi:10.1016/j.stem.2008.05.012
更新日期:2008-06-05 00:00:00
abstract::Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in niches, which are anatomically distinct regions within the tumor microenvironment. These niches maintain the principle properties of...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2015.02.015
更新日期:2015-03-05 00:00:00
abstract::Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation. Here, we present a fully automated, HTS-compatible platform for enhanced differentiation and...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.04.022
更新日期:2018-06-01 00:00:00
abstract::Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has proven valuable for studying their behavior in murine recipients. Now in Cell Stem Cell, Kim et al. (2014) and Wu et al. (2014) extend these analyses to nonhuman primates, providing insights into dynamics of HSPC expansion and lineage commitment fo...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.03.006
更新日期:2014-04-03 00:00:00
abstract::Chimeras are individuals with tissues derived from more than one zygote. Interspecific chimeras have tissues derived from different species. The biological consequences of human-animal chimeras have become an issue of ethical debate. Ironically, human-animal chimeras with human blood, neurons, germ cells, and other ti...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2007.07.021
更新日期:2007-09-13 00:00:00
abstract::Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to ...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2009.03.005
更新日期:2009-04-03 00:00:00