Abstract:
:A crucial limitation to our understanding of Alzheimer's disease has been the inability to test hypotheses on live, patient-specific neurons. A recent study in Nature by Israel et al. (2012) reports that iPSC-derived neurons from AD patients recapitulate multiple aspects of disease pathology.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Choi SH,Tanzi REdoi
10.1016/j.stem.2012.02.011subject
Has Abstractpub_date
2012-03-02 00:00:00pages
235-6issue
3eissn
1934-5909issn
1875-9777pii
S1934-5909(12)00069-0journal_volume
10pub_type
评论,杂志文章相关文献
Cell Stem Cell文献大全abstract::In this study, we explore endoderm cell fate regulation through the expression of lineage-determining transcription factors. We demonstrate that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm prog...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2008.06.018
更新日期:2008-08-07 00:00:00
abstract::Leukemia stem cells (LSCs) are resistant to current therapies used to treat chronic myeloid leukemia (CML). Abraham et al. (2016) have identified a molecular network critical for CML LSC survival and propose that simultaneously targeting two of their major transcriptional regulators, p53 and c-Myc, may facilitate thei...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2016.06.005
更新日期:2016-07-07 00:00:00
abstract::Mammalian embryonic stem cells (ESCs) can self-organize in vitro, but whether they can recreate early embryonic morphogenesis is unclear. Harrison et al. recently demonstrate in Science that 3D co-cultures of mouse ESCs and trophoblast stem cells self-organize into embryo-like structures that recreate many features of...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2017.04.001
更新日期:2017-05-04 00:00:00
abstract::Establishing tissue-specific adult stem cells during organogenesis is important for maintenance of tissue homeostasis throughout the lifetime of the organism. In a recent study in Science, Mathur et al. (2010) describe how progenitor cells in the Drosophila larval midgut create a temporary niche to maintain stem cell ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.02.010
更新日期:2010-03-05 00:00:00
abstract::To date, pluripotent epiblast stem cells (EpiSCs) had only been derived from postimplantation mouse embryos. In this issue of Cell Stem Cell, Najm et al. (2011) demonstrate that EpiSCs can be routinely derived from preimplantation embryos, showing that both human and mouse blastocysts can produce the same class of pri...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2011.02.009
更新日期:2011-03-04 00:00:00
abstract::Secreted frizzled-related protein 1 (Sfrp1) is highly expressed by stromal cells maintaining hematopoietic stem cells (HSCs). Sfrp1 loss in stromal cells increases production of hematopoietic progenitors, and in knockout mice, dysregulates hemostasis and increases Flk2- Cd34- Lin- Sca1+ Kit+ (LSK) cell numbers in bone...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.05.020
更新日期:2009-08-07 00:00:00
abstract::While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives p...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.03.006
更新日期:2015-04-02 00:00:00
abstract::Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages o...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.01.004
更新日期:2012-02-03 00:00:00
abstract::Newborn neurons in the adult dentate gyrus pass through several distinct precursor and progenitor classes prior to differentiation. In this issue of Cell Stem Cell, Lugert et al. (2010) characterized their strikingly different proliferative behaviors after neurogenic stimuli or aging. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2010.04.006
更新日期:2010-05-07 00:00:00
abstract::Embryonic stem cells (ESCs) are an attractive source for tissue regeneration and repair therapies because they can be differentiated into virtually any cell type in the adult body. However, for this approach to succeed, the transplanted ESCs must survive long enough to generate a therapeutic benefit. A major obstacle ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.01.012
更新日期:2011-03-04 00:00:00
abstract::Cerebral organoids represent a new model in which to study human brain development outside the human body. Recently in Nature Biotechnology, Lancaster et al. (2017) tackled the lack of reproducibility, tissue homogeneity, and complexity of this system by bioengineering organoids to establish the next generation of hum...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2017.07.001
更新日期:2017-08-03 00:00:00
abstract::Substantial expansion in the number of cerebral cortex neurons is thought to underlie cognitive differences between humans and other primates, although the mechanisms underlying this expansion are unclear. Otani et al. (2016) utilize PSC-derived brain organoids to study how species-specific differences in cortical pro...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2016.03.017
更新日期:2016-04-07 00:00:00
abstract::We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by a single neural transcription factor, NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrate that sequentia...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2015.09.012
更新日期:2015-12-03 00:00:00
abstract::Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling coordinated genome-wide activation of species- and context-specific gene expression programs, but such regulation must be balanced against th...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.03.012
更新日期:2019-05-02 00:00:00
abstract::The 2009 ISSCR Annual Meeting in Barcelona will draw stem cell scientists from around the world to Europe, to connect to each other and to the local community. With record abstract submissions, we are sure to have an exciting meeting. ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.05.009
更新日期:2009-06-05 00:00:00
abstract::Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of developmental and translational consequence. We propose that pluripotency transcription factors are lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the abil...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.03.013
更新日期:2011-04-08 00:00:00
abstract::The maintenance of a pool of quiescent satellite cells (muscle stem cells) is necessary for long-term muscle health. In this issue of Cell Stem Cell, Verma et al. (2018) show that satellite cells recruit endothelial cells to create a vascular niche and that cross-talk between endothelial and satellite cells is vital f...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2018.09.013
更新日期:2018-10-04 00:00:00
abstract::The nature of compensation for women who donate eggs (oocytes) for research remains a contentious issue internationally. This position paper lays out the arguments for, and discusses the arrangements in which, a modest payment might be ethically justifiable. ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.02.002
更新日期:2013-03-07 00:00:00
abstract::Although the clinical outcomes of cell therapy trials have not met initial expectations, emerging evidence suggests that injury-mediated tissue damage might benefit from the delivery of cells or their secreted products. Pluripotent stem cells (PSCs) are promising cell sources primarily because of their capacity to gen...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2019.10.001
更新日期:2019-11-07 00:00:00
abstract::Stem-cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human pluripotent stem cells (hPSCs) differentiate into pancreatic islets in vitro by profiling DNA methylation, chromatin accessibility, and histone modification changes...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.11.011
更新日期:2020-01-02 00:00:00
abstract::Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not recapitulate critical myelination phenotypes and it is therefore not c...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.07.009
更新日期:2018-08-02 00:00:00
abstract::Significant development in the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has been achieved by retroviral infection of defined genes. Several recent reports, including one in this issue of Cell Stem Cell (Marson et al., 2008), have started to replace these genetic changes with specific ...
journal_title:Cell stem cell
pub_type: 评论
doi:10.1016/j.stem.2008.07.005
更新日期:2008-08-07 00:00:00
abstract::Scientists are rarely immoral and seldom even amoral. The ethical principles that underlie much of their own work are shared with scientists in other countries to a much greater degree than the cultural and religious differences among those countries would lead one to expect. Like me, few will have had any formal trai...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2007.05.003
更新日期:2007-06-07 00:00:00
abstract::Bmi1 is required for efficient self-renewal of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). In this study, we investigated whether leukemia-associated fusion proteins, which differ in their ability to activate Hox expression, could initiate leukemia in the absence of Bmi1. AML1-ETO and PLZF-RARα, wh...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.05.004
更新日期:2011-06-03 00:00:00
abstract::The generation of human embryonic stem cell banking networks has ensured that well-characterized and quality controlled stem cell lines are broadly accessible to researchers worldwide. Here, we provide recommendations for engaging these established networks in efforts to build similar resources for the distribution an...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.09.007
更新日期:2013-10-03 00:00:00
abstract::Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process through directly activating fatty acid o...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.06.005
更新日期:2020-09-03 00:00:00
abstract::In response to muscle injury, satellite cells activate the p38α/β MAPK pathway to exit quiescence, then proliferate, repair skeletal muscle, and self-renew, replenishing the quiescent satellite cell pool. Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite cell self-renewal...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.05.025
更新日期:2012-10-05 00:00:00
abstract::Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonica...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2013.01.014
更新日期:2013-02-07 00:00:00
abstract::Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2015.08.005
更新日期:2015-11-05 00:00:00
abstract::About half of the human genome consists of highly repetitive elements, most of which are considered dispensable for human life. Here, we report that repetitive elements originating from endogenous retroviruses (ERVs) are systematically transcribed during human early embryogenesis in a stage-specific manner. Our analys...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2015.01.005
更新日期:2015-02-05 00:00:00