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A precarious balance: pluripotency factors as lineage specifiers.

Abstract：

:Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of developmental and translational consequence. We propose that pluripotency transcription factors are lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the ability to differentiate into particular cell types, and concomitant expression of multiple lineage specifiers within pluripotent cells enables differentiation into every fetal lineage. Moreover, we speculate that, rather than being an intrinsically stable "ground state," pluripotency is an inherently precarious condition in which rival lineage specifiers continually compete to specify differentiation along mutually exclusive lineages.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Loh KM,Lim B

doi

10.1016/j.stem.2011.03.013

subject

Has Abstract

pub_date

2011-04-08 00:00:00

pages

363-9

issue

4

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(11)00125-1

journal_volume

8

pub_type

杂志文章

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