Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming.

Abstract:

:Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcription and high replication rates are to blame.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Hu X,Guo S

doi

10.1016/j.stem.2019.09.007

subject

Has Abstract

pub_date

2019-10-03 00:00:00

pages

451-453

issue

4

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(19)30392-3

journal_volume

25

pub_type

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