Position statement on the provision and procurement of human eggs for stem cell research.

abstract：:Realizing the therapeutic potential of both stem cell and genomics research requires harnessing the respective strengths of academic, biotechnology, and pharmaceutical sectors, supported by policies and legal incentives for multisectorial collaboration. Here, we discuss issues facing these fields and lessons from the ...

journal_title：Cell stem cell

authors： Mathews DJ,Cook-Deegan R,Bubela T

更新日期：2013-05-02 00:00:00

abstract：:SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental pl...

journal_title：Cell stem cell

authors： Yang L,Han Y,Nilsson-Payant BE,Gupta V,Wang P,Duan X,Tang X,Zhu J,Zhao Z,Jaffré F,Zhang T,Kim TW,Harschnitz O,Redmond D,Houghton S,Liu C,Naji A,Ciceri G,Guttikonda S,Bram Y,Nguyen DT,Cioffi M,Chandar V,Hoagl

更新日期：2020-07-02 00:00:00

abstract：:Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaer...

journal_title：Cell stem cell

authors： Suda T,Takubo K,Semenza GL

更新日期：2011-10-04 00:00:00

abstract：:The California Institute for Regenerative Medicine (CIRM) Alpha Stem Cell Clinic (ASCC) Network was launched in 2015 to address a compelling unmet medical need for rigorous, FDA-regulated, stem cell-related clinical trials for patients with challenging, incurable diseases. Here, we describe our multi-center experience...

journal_title：Cell stem cell

authors： Jamieson CHM,Millan MT,Creasey AA,Lomax G,Donohoe ME,Walters MC,Abedi M,Bota DA,Zaia JA,Adams JS

更新日期：2018-06-01 00:00:00

abstract：:Recently in Cell, Mitalipov and colleagues report an advance that has eluded scientists for over a decade-the successful derivation of embryonic stem cell lines using somatic cell nuclear transfer, or SCNT (Tachibana et al., 2013). ...

journal_title：Cell stem cell

authors： Trounson A,DeWitt ND

更新日期：2013-06-06 00:00:00

abstract：:The generation of induced pluripotent stem cells (iPSCs) provides a novel method to facilitate investigations into the mechanisms that control stem cell pluripotency and self-renewal. Myc has previously been shown to be critical for murine embryonic stem cell (mESC) maintenance, while also enhancing directed reprogram...

journal_title：Cell stem cell

authors： Smith KN,Singh AM,Dalton S

更新日期：2010-09-03 00:00:00

abstract：:In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...

journal_title：Cell stem cell

authors： Cosgun KN,Rahmig S,Mende N,Reinke S,Hauber I,Schäfer C,Petzold A,Weisbach H,Heidkamp G,Purbojo A,Cesnjevar R,Platz A,Bornhäuser M,Schmitz M,Dudziak D,Hauber J,Kirberg J,Waskow C

更新日期：2014-08-07 00:00:00

abstract：:Pluripotent stem cells (PSCs) could provide a powerful system to model development of the human esophagus, whose distinct tissue organization compared to rodent esophagus suggests that developmental mechanisms may not be conserved between species. We therefore established an efficient protocol for generating esophagea...

journal_title：Cell stem cell

authors： Zhang Y,Yang Y,Jiang M,Huang SX,Zhang W,Al Alam D,Danopoulos S,Mori M,Chen YW,Balasubramanian R,Chuva de Sousa Lopes SM,Serra C,Bialecka M,Kim E,Lin S,Toste de Carvalho ALR,Riccio PN,Cardoso WV,Zhang X,Snoeck HW,Q

更新日期：2018-10-04 00:00:00

abstract：:Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...

journal_title：Cell stem cell

authors： Jalkanen AL,Wilusz J

更新日期：2014-12-04 00:00:00

abstract：:Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that...

journal_title：Cell stem cell

authors： Manley WF,Anderson SA

更新日期：2019-06-06 00:00:00

abstract：:Systems biology studies have revealed transcriptional networks and proteomic signatures critical for embryonic stem cell (ESC) function. In this issue of Cell Stem Cell, Sampath et al. (2008) demonstrate that translation is also differentially controlled in undifferentiated versus differentiated ESCs. ...

journal_title：Cell stem cell

authors： Chang WY,Stanford WL

更新日期：2008-05-08 00:00:00

abstract：:Heterogeneity within the self-renewal durability of adult hematopoietic stem cells (HSCs) challenges our understanding of the molecular framework underlying HSC function. Gene expression studies have been hampered by the presence of multiple HSC subtypes and contaminating non-HSCs in bulk HSC populations. To gain deep...

journal_title：Cell stem cell

authors： Wilson NK,Kent DG,Buettner F,Shehata M,Macaulay IC,Calero-Nieto FJ,Sánchez Castillo M,Oedekoven CA,Diamanti E,Schulte R,Ponting CP,Voet T,Caldas C,Stingl J,Green AR,Theis FJ,Göttgens B

更新日期：2015-06-04 00:00:00

abstract：:Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling pathways preferentially enriched in GSCs. We identified integ...

journal_title：Cell stem cell

authors： Haas TL,Sciuto MR,Brunetto L,Valvo C,Signore M,Fiori ME,di Martino S,Giannetti S,Morgante L,Boe A,Patrizii M,Warnken U,Schnölzer M,Ciolfi A,Di Stefano C,Biffoni M,Ricci-Vitiani L,Pallini R,De Maria R

更新日期：2017-07-06 00:00:00

abstract：:In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 genes. We were able to predict causal variants for these expression quantitative trait loci (e...

journal_title：Cell stem cell

authors： DeBoever C,Li H,Jakubosky D,Benaglio P,Reyna J,Olson KM,Huang H,Biggs W,Sandoval E,D'Antonio M,Jepsen K,Matsui H,Arias A,Ren B,Nariai N,Smith EN,D'Antonio-Chronowska A,Farley EK,Frazer KA

更新日期：2017-04-06 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed a proof-of-concept for hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide th...

journal_title：Cell stem cell

authors： Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Ma

更新日期：2019-10-03 00:00:00

abstract：:The identification of tumor-initiating cells represents a significant challenge for studies of prostate cancer. In a recent issue of Cell Reports, Agarwal and colleagues use organoid culture to ascertain two distinct luminal progenitors in a mouse model of prostate cancer, shedding new light on lineage relationships i...

journal_title：Cell stem cell

authors： Shen MM

更新日期：2015-12-03 00:00:00

abstract：:The 2009 ISSCR Annual Meeting in Barcelona will draw stem cell scientists from around the world to Europe, to connect to each other and to the local community. With record abstract submissions, we are sure to have an exciting meeting. ...

journal_title：Cell stem cell

authors： McKay RD

更新日期：2009-06-05 00:00:00

abstract：:Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for regenerative medicine. Herein we provide a perspective regarding these developments, compare phenotypes of the insulin-containing cells to human β cells, and discuss impli...

journal_title：Cell stem cell

authors： Kushner JA,MacDonald PE,Atkinson MA

更新日期：2014-11-06 00:00:00

abstract：:Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing (RNA-seq). The transcriptomes of multiple cycling ISC populations clo...

journal_title：Cell stem cell

authors： Yan KS,Gevaert O,Zheng GXY,Anchang B,Probert CS,Larkin KA,Davies PS,Cheng ZF,Kaddis JS,Han A,Roelf K,Calderon RI,Cynn E,Hu X,Mandleywala K,Wilhelmy J,Grimes SM,Corney DC,Boutet SC,Terry JM,Belgrader P,Ziraldo SB

更新日期：2017-07-06 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem cells (iPSCs) via exogenous transcription factors but the underlying mechanism is unclear. Here we show that the generation of iPSCs fro...

journal_title：Cell stem cell

authors： Li R,Liang J,Ni S,Zhou T,Qing X,Li H,He W,Chen J,Li F,Zhuang Q,Qin B,Xu J,Li W,Yang J,Gan Y,Qin D,Feng S,Song H,Yang D,Zhang B,Zeng L,Lai L,Esteban MA,Pei D

更新日期：2010-07-02 00:00:00

abstract：:Developing technologies for efficient and scalable disruption of gene expression will provide powerful tools for studying gene function, developmental pathways, and disease mechanisms. Here, we develop clustered regularly interspaced short palindromic repeat interference (CRISPRi) to repress gene expression in human i...

journal_title：Cell stem cell

authors： Mandegar MA,Huebsch N,Frolov EB,Shin E,Truong A,Olvera MP,Chan AH,Miyaoka Y,Holmes K,Spencer CI,Judge LM,Gordon DE,Eskildsen TV,Villalta JE,Horlbeck MA,Gilbert LA,Krogan NJ,Sheikh SP,Weissman JS,Qi LS,So PL,Conk

更新日期：2016-04-07 00:00:00

abstract：:Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved. Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions. Like cells of the blastocyst, the resulting naive ...

journal_title：Cell stem cell

authors： Sahakyan A,Kim R,Chronis C,Sabri S,Bonora G,Theunissen TW,Kuoy E,Langerman J,Clark AT,Jaenisch R,Plath K

更新日期：2017-01-05 00:00:00

abstract：:Regeneration of skin and hair follicles after wounding--a process known as wound-induced hair neogenesis (WIHN)--is a rare example of adult organogenesis in mammals. As such, WIHN provides a unique model system for deciphering mechanisms underlying mammalian regeneration. Here, we show that dsRNA, which is released fr...

journal_title：Cell stem cell

authors： Nelson AM,Reddy SK,Ratliff TS,Hossain MZ,Katseff AS,Zhu AS,Chang E,Resnik SR,Page C,Kim D,Whittam AJ,Miller LS,Garza LA

更新日期：2015-08-06 00:00:00

abstract：:Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...

journal_title：Cell stem cell

authors： Chu SH,Heiser D,Li L,Kaplan I,Collector M,Huso D,Sharkis SJ,Civin C,Small D

更新日期：2012-09-07 00:00:00

abstract：:Stroma is a largely understudied component of all organs that contributes to stem cell niches. Studies to define stromal components in the bone marrow have led to some unexpected findings that prompt further research. ...

journal_title：Cell stem cell

authors： Scadden DT

更新日期：2012-06-14 00:00:00

abstract：:Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determina...

journal_title：Cell stem cell

authors： Wang C,Fong H,Huang Y

更新日期：2015-07-02 00:00:00

abstract：:Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various therapeutic and research applications. However, several problems remain for t...

journal_title：Cell stem cell

authors： Shi Y,Desponts C,Do JT,Hahm HS,Schöler HR,Ding S

更新日期：2008-11-06 00:00:00

abstract：:To date, pluripotent epiblast stem cells (EpiSCs) had only been derived from postimplantation mouse embryos. In this issue of Cell Stem Cell, Najm et al. (2011) demonstrate that EpiSCs can be routinely derived from preimplantation embryos, showing that both human and mouse blastocysts can produce the same class of pri...

journal_title：Cell stem cell

authors： Kunath T

更新日期：2011-03-04 00:00:00

abstract：:Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not recapitulate critical myelination phenotypes and it is therefore not c...

journal_title：Cell stem cell

authors： Li L,Tian E,Chen X,Chao J,Klein J,Qu Q,Sun G,Sun G,Huang Y,Warden CD,Ye P,Feng L,Li X,Cui Q,Sultan A,Douvaras P,Fossati V,Sanjana NE,Riggs AD,Shi Y

更新日期：2018-08-02 00:00:00

abstract：:Stem cell niche interactions have been studied extensively with regard to cell polarity and extracellular signaling. Less is known about the way in which signals and polarity cues integrate with intracellular structures to ensure appropriate niche organization and function. Here, we report that nuclear lamins function...

journal_title：Cell stem cell

authors： Chen H,Chen X,Zheng Y

更新日期：2013-07-03 00:00:00