Abstract:
:Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for regenerative medicine. Herein we provide a perspective regarding these developments, compare phenotypes of the insulin-containing cells to human β cells, and discuss implications for type 1 diabetes research and clinical care.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Kushner JA,MacDonald PE,Atkinson MAdoi
10.1016/j.stem.2014.10.012subject
Has Abstractpub_date
2014-11-06 00:00:00pages
535-6issue
5eissn
1934-5909issn
1875-9777pii
S1934-5909(14)00463-9journal_volume
15pub_type
杂志文章相关文献
Cell Stem Cell文献大全abstract::Recently in Cell, Mitalipov and colleagues report an advance that has eluded scientists for over a decade-the successful derivation of embryonic stem cell lines using somatic cell nuclear transfer, or SCNT (Tachibana et al., 2013). ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2013.05.022
更新日期:2013-06-06 00:00:00
abstract::Human induced pluripotent stem cells (HiPSCs) appear to be highly similar to human embryonic stem cells (HESCs). Using two genetic lineage-tracing systems, we demonstrate the generation of iPSC lines from human pancreatic islet beta cells. These reprogrammed cells acquired markers of pluripotent cells and differentiat...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.06.007
更新日期:2011-07-08 00:00:00
abstract::In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cyc...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2018.12.005
更新日期:2019-01-03 00:00:00
abstract::Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). However, this process is typically very inefficient, complicating mechanistic studies. We identified and molecularly characterized rare, early intermediates poised to reprogram with up to 95% efficiency, without perturbin...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.06.013
更新日期:2018-08-02 00:00:00
abstract::The identification of tumor-initiating cells represents a significant challenge for studies of prostate cancer. In a recent issue of Cell Reports, Agarwal and colleagues use organoid culture to ascertain two distinct luminal progenitors in a mouse model of prostate cancer, shedding new light on lineage relationships i...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.11.018
更新日期:2015-12-03 00:00:00
abstract::Steroid hormones are known systemic regulators of multiple normal and cancerous tissues; however, whether or how they impact the fate and function of adult stem cells is unclear. In the Drosophila ovary, insulin signals modulate the proliferation and self-renewal of germline stem cells (GSCs), yet despite evidence tha...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.10.001
更新日期:2010-11-05 00:00:00
abstract::Neural precursor cells (NPCs) reside in the subventricular zone in association with blood vessels and ependymal cells. In this issue of Cell Stem Cell, Kokovay et al. (2010) show that SDF1 directs the association of NPCs with this niche and regulates their lineage progression in a stage-specific manner. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2010.07.001
更新日期:2010-08-06 00:00:00
abstract::Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.11.011
更新日期:2014-12-04 00:00:00
abstract::Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2012.12.005
更新日期:2013-01-03 00:00:00
abstract::Like politics, most developmental signals are local. However, in this issue of Cell Stem Cell, Kwan et al. (2016) and colleagues describe how a stress-induced signal that originates in the zebrafish brain promotes the formation of blood at a distant site, the dorsal aorta. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2016.08.011
更新日期:2016-09-01 00:00:00
abstract::Significant development in the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has been achieved by retroviral infection of defined genes. Several recent reports, including one in this issue of Cell Stem Cell (Marson et al., 2008), have started to replace these genetic changes with specific ...
journal_title:Cell stem cell
pub_type: 评论
doi:10.1016/j.stem.2008.07.005
更新日期:2008-08-07 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem cells (iPSCs) via exogenous transcription factors but the underlying mechanism is unclear. Here we show that the generation of iPSCs fro...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.04.014
更新日期:2010-07-02 00:00:00
abstract::With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during preimplantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demethylation, but demethy...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2014.09.002
更新日期:2014-10-02 00:00:00
abstract::Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool, as a consequence of their division, may contribute to the age-related decrease in hippocampal neurogenesis. Our results...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.03.010
更新日期:2011-05-06 00:00:00
abstract::Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently because the injected cells undergo apoptosis. Here we show that transient promotion of cell survival through expression of the anti-apoptot...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.10.013
更新日期:2016-11-03 00:00:00
abstract::In this issue of Cell Stem Cell, Li et al. (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intestinal homeostasis through TEAD-dependent and -independent transcription. Loss of Lats1/2 mobilizes a previously unrecognized YAP/TAZ-Groucho/TLE interaction to suppress Wnt/TCF-mediated transcription, thereby...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2020.04.011
更新日期:2020-05-07 00:00:00
abstract::Leukemia stem cells (LSCs) are resistant to current therapies used to treat chronic myeloid leukemia (CML). Abraham et al. (2016) have identified a molecular network critical for CML LSC survival and propose that simultaneously targeting two of their major transcriptional regulators, p53 and c-Myc, may facilitate thei...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2016.06.005
更新日期:2016-07-07 00:00:00
abstract::The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-trac...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.08.013
更新日期:2016-12-01 00:00:00
abstract::Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2017.09.014
更新日期:2017-11-02 00:00:00
abstract::In a pioneering study in New England Journal of Medicine, Schweitzer et al. (2020) report on a patient with Parkinson's disease who received a graft of dopamine neurons obtained from in vitro differentiated induced pluripotent stem cells, derived from the patient's own skin fibroblasts, showing the feasibility of auto...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.06.008
更新日期:2020-07-02 00:00:00
abstract::Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.05.027
更新日期:2012-09-07 00:00:00
abstract::Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.02.003
更新日期:2014-03-06 00:00:00
abstract::The nature of compensation for women who donate eggs (oocytes) for research remains a contentious issue internationally. This position paper lays out the arguments for, and discusses the arrangements in which, a modest payment might be ethically justifiable. ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.02.002
更新日期:2013-03-07 00:00:00
abstract::Two recent papers in Cell Stem Cell by Soliman et al. (2020) and Scott et al. (2019) explore the contributions of mesenchymal progenitor cells to fibrosis in heart and skeletal muscle. They find tissue-dependent roles for a subpopulation of mesenchymal progenitors expressing Hic1 with varied differentiation capacities...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2019.12.010
更新日期:2020-02-06 00:00:00
abstract::3D organoids enable in vitro human brain development models, but they have not yet recapitulated some essential features of brain circuit formation. Recently, several studies appearing in Nature, Nature Methods, and Cell Stem Cell generated fused organoid models of inhibitory and excitatory neuron development, which c...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2017.08.017
更新日期:2017-09-07 00:00:00
abstract::While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives p...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.03.006
更新日期:2015-04-02 00:00:00
abstract::Regulation of hematopoietic stem cell (HSC) dormancy by specific cell types in the hematopoietic niche remains poorly understood. Yamazaki et al. (2011) now report that nerve-associated nonmyelinating Schwann cells activate TGF-β to maintain dormant HSCs, suggesting that glia are novel players in the bone marrow niche...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2011.11.016
更新日期:2011-12-02 00:00:00
abstract::Cell cycle regulators play critical roles in the balance between hematopoietic stem cell (HSC) dormancy and proliferation. In this study, we report that cell cycle entry proceeded normally in HSCs null for cyclin-dependent kinase (CDK) inhibitor p57 due to compensatory upregulation of p27. HSCs null for both p57 and p...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.07.003
更新日期:2011-09-02 00:00:00
abstract::In this issue of Cell Stem Cell, Csaszar et al. (2012) develop a culture method that overcomes current limitations in ex vivo hematopoietic stem/progenitor cell expansion by continuously diluting inhibitory signaling factors and maintaining stem cell density. This approach enhances the generation of precursors with po...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2012.01.012
更新日期:2012-02-03 00:00:00
abstract::Individuals with neurofibromatosis type 1 (NF1) develop abnormalities of both neuronal and glial cell lineages, suggesting that the NF1 protein neurofibromin is an essential regulator of neuroglial progenitor function. In this regard, Nf1-deficient embryonic telencephalic neurospheres exhibit increased self-renewal an...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2007.07.008
更新日期:2007-10-11 00:00:00