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The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila.

Abstract：

:Steroid hormones are known systemic regulators of multiple normal and cancerous tissues; however, whether or how they impact the fate and function of adult stem cells is unclear. In the Drosophila ovary, insulin signals modulate the proliferation and self-renewal of germline stem cells (GSCs), yet despite evidence that additional systemic factors control GSC activity, these have remained largely unknown. Here, we report that ecdysone, a steroid hormone structurally related to mammalian sex steroids, directly regulates adult GSC proliferation and self-renewal independently of insulin signaling. Ecdysone controls GSCs through a functional interaction with the chromatin remodeling factors ISWI, an intrinsic epigenetic factor required for GSC fate and activity, and Nurf301, the largest subunit of the ISWI-containing NURF chromatin remodeling complex. Our findings support a link between systemic steroid hormones and the intrinsic chromatin remodeling machinery as a potential mechanism to promote broad transcriptional programs required for adult stem cell self-renewal.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Ables ET,Drummond-Barbosa D

doi

10.1016/j.stem.2010.10.001

subject

Has Abstract

pub_date

2010-11-05 00:00:00

pages

581-92

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(10)00514-X

journal_volume

7

pub_type

杂志文章

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