Introductions to the Community: Early-Career Researchers in the Time of COVID-19.

Abstract:

:COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell investigators impacted by the closures. Here, they introduce themselves and their research to our readers.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

doi

10.1016/j.stem.2020.06.011

subject

Has Abstract

pub_date

2020-07-02 00:00:00

pages

13-14

issue

1

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(20)30278-2

journal_volume

27

pub_type

杂志文章
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  • Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis.

    abstract::Adipocyte progenitors (APs) express platelet-derived growth factor receptors (PDGFRs), PDGFRα and PDGFRβ. Elevated PDGFRα signaling inhibits adipogenesis and promotes fibrosis; however, the function of PDGFRs in APs remains unclear. We combined lineage tracing and functional analyses in a sequential dual-recombinase a...

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  • Reprogramming can be a transforming experience.

    abstract::Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...

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    authors: Hobbs RM,Polo JM

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  • Slow Your Roll: Inhibiting SETD7 Activity Permits Ex Vivo Expansion of Muscle Stem Cells.

    abstract::Muscle stem cell regenerative capacity is rapidly lost during ex vivo culture. In this issue of Cell Stem Cell, Judson et al. (2018) show that inhibition of cytoplasmic SETD7, a lysine methyltransferase, potently expands naive, undifferentiated mouse and human muscle stem cells by restricting their progression through...

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    doi:10.1016/j.stem.2018.01.007

    authors: Fujita R,Crist C

    更新日期:2018-02-01 00:00:00

  • Rethinking stroma: lessons from the blood.

    abstract::Stroma is a largely understudied component of all organs that contributes to stem cell niches. Studies to define stromal components in the bone marrow have led to some unexpected findings that prompt further research. ...

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    authors: Scadden DT

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  • CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges.

    abstract::The California Institute for Regenerative Medicine (CIRM) Alpha Stem Cell Clinic (ASCC) Network was launched in 2015 to address a compelling unmet medical need for rigorous, FDA-regulated, stem cell-related clinical trials for patients with challenging, incurable diseases. Here, we describe our multi-center experience...

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  • Erosion of dosage compensation impacts human iPSC disease modeling.

    abstract::Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage female hiPSCs retain the inactive X chromosome of the somatic cell they are...

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    更新日期:2012-05-04 00:00:00

  • Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development.

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    doi:10.1016/j.stem.2018.06.008

    authors: Matoba S,Wang H,Jiang L,Lu F,Iwabuchi KA,Wu X,Inoue K,Yang L,Press W,Lee JT,Ogura A,Shen L,Zhang Y

    更新日期:2018-09-06 00:00:00

  • iPSCs to the rescue in Alzheimer's research.

    abstract::A crucial limitation to our understanding of Alzheimer's disease has been the inability to test hypotheses on live, patient-specific neurons. A recent study in Nature by Israel et al. (2012) reports that iPSC-derived neurons from AD patients recapitulate multiple aspects of disease pathology. ...

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    authors: Choi SH,Tanzi RE

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  • Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

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    更新日期:2019-10-03 00:00:00

  • There's no place like home for a neural stem cell.

    abstract::Neural precursor cells (NPCs) reside in the subventricular zone in association with blood vessels and ependymal cells. In this issue of Cell Stem Cell, Kokovay et al. (2010) show that SDF1 directs the association of NPCs with this niche and regulates their lineage progression in a stage-specific manner. ...

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  • Out of Many, One: Computational Reconstruction of Mouse Skin using Single-Cell Transcriptomics.

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  • A 3D Tissue-wide Digital Imaging Pipeline for Quantitation of Secreted Molecules Shows Absence of CXCL12 Gradients in Bone Marrow.

    abstract::Technological limitations have hampered understanding of how individual molecules, including putative stem cell regulators, are distributed throughout tissues and stem cell niches. Here, we report adaptation of the proximity ligation assay (PLA) for large-volume, in situ imaging of individual proteins with multiple ad...

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    authors: Kunz L,Schroeder T

    更新日期:2019-12-05 00:00:00

  • Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK.

    abstract::In response to muscle injury, satellite cells activate the p38α/β MAPK pathway to exit quiescence, then proliferate, repair skeletal muscle, and self-renew, replenishing the quiescent satellite cell pool. Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite cell self-renewal...

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    authors: Troy A,Cadwallader AB,Fedorov Y,Tyner K,Tanaka KK,Olwin BB

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  • A Little Bit of Guidance: Mini Brains on Their Route to Adolescence.

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    authors: Koch P,Ladewig J

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  • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.

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    authors: Li R,Liang J,Ni S,Zhou T,Qing X,Li H,He W,Chen J,Li F,Zhuang Q,Qin B,Xu J,Li W,Yang J,Gan Y,Qin D,Feng S,Song H,Yang D,Zhang B,Zeng L,Lai L,Esteban MA,Pei D

    更新日期:2010-07-02 00:00:00

  • Close Quarters Can Be a Good Fit for Stem Cells to Become T Cells.

    abstract::Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hematopoietic differentia...

    journal_title:Cell stem cell

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    doi:10.1016/j.stem.2019.02.013

    authors: Trotman-Grant A,Zúñiga-Pflücker JC

    更新日期:2019-03-07 00:00:00

  • Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

    abstract::Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed a proof-of-concept for hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide th...

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    doi:10.1016/j.stem.2019.08.004

    authors: Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Ma

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  • Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions.

    abstract::Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for maintenance of the species. However, the developmental trajectories and heterogeneity of human FGCs remain largely unknown. Here we performed single-cell RNA-seq analysis of over 2,000 FGCs and their gonadal niche cells in female and ma...

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    doi:10.1016/j.stem.2017.03.007

    authors: Li L,Dong J,Yan L,Yong J,Liu X,Hu Y,Fan X,Wu X,Guo H,Wang X,Zhu X,Li R,Yan J,Wei Y,Zhao Y,Wang W,Ren Y,Yuan P,Yan Z,Hu B,Guo F,Wen L,Tang F,Qiao J

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  • A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.

    abstract::While gene expression dynamics have been extensively cataloged during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and post-transcriptional changes in HSCs during development, we leve...

    journal_title:Cell stem cell

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    doi:10.1016/j.stem.2018.03.012

    authors: Cesana M,Guo MH,Cacchiarelli D,Wahlster L,Barragan J,Doulatov S,Vo LT,Salvatori B,Trapnell C,Clement K,Cahan P,Tsanov KM,Sousa PM,Tazon-Vega B,Bolondi A,Giorgi FM,Califano A,Rinn JL,Meissner A,Hirschhorn JN,Daley

    更新日期:2018-04-05 00:00:00

  • A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

    abstract::Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly effective treatments. Here, we describe a new small molecule survival screen carried out using MNs from both wild-type and mutant SOD1 mouse embryonic stem cell...

    journal_title:Cell stem cell

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    doi:10.1016/j.stem.2013.04.003

    authors: Yang YM,Gupta SK,Kim KJ,Powers BE,Cerqueira A,Wainger BJ,Ngo HD,Rosowski KA,Schein PA,Ackeifi CA,Arvanites AC,Davidow LS,Woolf CJ,Rubin LL

    更新日期:2013-06-06 00:00:00

  • An epigenomic road map for endoderm development.

    abstract::While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives p...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2015.03.006

    authors: Kaestner KH

    更新日期:2015-04-02 00:00:00

  • Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

    abstract::Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various therapeutic and research applications. However, several problems remain for t...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2008.10.004

    authors: Shi Y,Desponts C,Do JT,Hahm HS,Schöler HR,Ding S

    更新日期:2008-11-06 00:00:00

  • Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.

    abstract::The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficientl...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2016.02.016

    authors: Tang H,Hammack C,Ogden SC,Wen Z,Qian X,Li Y,Yao B,Shin J,Zhang F,Lee EM,Christian KM,Didier RA,Jin P,Song H,Ming GL

    更新日期:2016-05-05 00:00:00

  • Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming.

    abstract::Direct cellular reprogramming provides a powerful platform to study cell plasticity and dissect mechanisms underlying cell fate determination. Here, we report a single-cell transcriptomic study of human cardiac (hiCM) reprogramming that utilizes an analysis pipeline incorporating current data normalization methods, mu...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.05.020

    authors: Zhou Y,Liu Z,Welch JD,Gao X,Wang L,Garbutt T,Keepers B,Ma H,Prins JF,Shen W,Liu J,Qian L

    更新日期:2019-07-03 00:00:00

  • Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway.

    abstract::The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting co...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2013.10.002

    authors: Gallagher D,Norman AA,Woodard CL,Yang G,Gauthier-Fisher A,Fujitani M,Vessey JP,Cancino GI,Sachewsky N,Woltjen K,Fatt MP,Morshead CM,Kaplan DR,Miller FD

    更新日期:2013-11-07 00:00:00

  • Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.

    abstract::Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated with tyrosine kinase inhibitors (TKIs). TKIs do not eliminate disease-propagating leukemic stem cells (LSCs), suggesting a deeper understandi...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.02.018

    authors: Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R

    更新日期:2019-05-02 00:00:00

  • CDK6 levels regulate quiescence exit in human hematopoietic stem cells.

    abstract::Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unkn...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2015.01.017

    authors: Laurenti E,Frelin C,Xie S,Ferrari R,Dunant CF,Zandi S,Neumann A,Plumb I,Doulatov S,Chen J,April C,Fan JB,Iscove N,Dick JE

    更新日期:2015-03-05 00:00:00

  • Autoimmune T cells lured to a FASL web of death by MSCs.

    abstract::Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2012.04.013

    authors: Murphy WJ,Nolta JA

    更新日期:2012-05-04 00:00:00

  • Stress Can Be a Good Thing for Blood Formation.

    abstract::Like politics, most developmental signals are local. However, in this issue of Cell Stem Cell, Kwan et al. (2016) and colleagues describe how a stress-induced signal that originates in the zebrafish brain promotes the formation of blood at a distant site, the dorsal aorta. ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2016.08.011

    authors: Speck NA

    更新日期:2016-09-01 00:00:00