Abstract:
:Mammalian skin is a complex and heterogeneous tissue with several distinct compartments and stem cell populations. Joost et al. (2016) now use single-cell RNaseq to comprehensively reconstruct this complexity, revealing spatial and pseudotemporal differences between transcriptional programs in distinct compartments and a common basal program in skin stem cell populations.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Chen JC,Christiano AMdoi
10.1016/j.stem.2016.09.009subject
Has Abstractpub_date
2016-10-06 00:00:00pages
421-422issue
4eissn
1934-5909issn
1875-9777pii
S1934-5909(16)30303-4journal_volume
19pub_type
评论,杂志文章相关文献
Cell Stem Cell文献大全abstract::Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.06.012
更新日期:2019-07-03 00:00:00
abstract::Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by reprogramming their nuclei to a totipotent state. However, successful full-term development of SCNT embryos is a low-efficiency process and arrested embryos frequently exhibit epigenetic abnormalities. Here, we generated genome-wide DNA me...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.07.017
更新日期:2018-09-06 00:00:00
abstract::The lineage restriction of prospectively isolated hematopoietic progenitors has been traditionally assessed by bulk in vitro culture and transplantation of large number of cells in vivo. These methods, however, cannot distinguish between homogenous multipotent or heterogeneous lineage-restricted populations. Using clo...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.02.013
更新日期:2010-04-02 00:00:00
abstract::Neural precursor cells (NPCs) reside in the subventricular zone in association with blood vessels and ependymal cells. In this issue of Cell Stem Cell, Kokovay et al. (2010) show that SDF1 directs the association of NPCs with this niche and regulates their lineage progression in a stage-specific manner. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2010.07.001
更新日期:2010-08-06 00:00:00
abstract::Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2015.08.005
更新日期:2015-11-05 00:00:00
abstract::Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested that ESCs and iPSCs...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.06.015
更新日期:2010-08-06 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem cells (iPSCs) via exogenous transcription factors but the underlying mechanism is unclear. Here we show that the generation of iPSCs fro...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.04.014
更新日期:2010-07-02 00:00:00
abstract::Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets d...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.04.009
更新日期:2015-05-07 00:00:00
abstract::Mesenchymal stem/stromal cells (MSCs) can either suppress or promote tumors. We found previously that incubation of human bone marrow MSCs (hMSCs) with TNF-α upregulated multiple genes including TRAIL, which has cancer apoptotic activity. Here, we show that weekly infusions into mice of hMSCs preactivated with TNF-α i...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.10.001
更新日期:2012-12-07 00:00:00
abstract::The generation of induced pluripotent stem cells (iPSCs) provides a novel method to facilitate investigations into the mechanisms that control stem cell pluripotency and self-renewal. Myc has previously been shown to be critical for murine embryonic stem cell (mESC) maintenance, while also enhancing directed reprogram...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.06.023
更新日期:2010-09-03 00:00:00
abstract::Neuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neurons or skeletal muscles in monolayer culture. Here, we use hPSC-deriv...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.12.007
更新日期:2020-02-06 00:00:00
abstract::Chronic liver injury can cause cirrhosis and impaired liver regeneration, impairing organ function. Adult livers can regenerate in response to parenchymal insults, and multiple cellular sources have been reported to contribute to this response. In this study, we modeled human chronic liver injuries, in which such resp...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.05.022
更新日期:2018-07-05 00:00:00
abstract::Cell-autonomous Wnt signaling has well-characterized functions in controlling stem cell activity, including in the prostate. While niche cells secrete Wnt ligands, the effects of Wnt signaling in niche cells per se are less understood. Here, we show that stromal cells in the proximal prostatic duct near the urethra, a...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.03.010
更新日期:2019-05-02 00:00:00
abstract::Adipocyte progenitors (APs) express platelet-derived growth factor receptors (PDGFRs), PDGFRα and PDGFRβ. Elevated PDGFRα signaling inhibits adipogenesis and promotes fibrosis; however, the function of PDGFRs in APs remains unclear. We combined lineage tracing and functional analyses in a sequential dual-recombinase a...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.03.004
更新日期:2020-05-07 00:00:00
abstract::Stem cell niche interactions have been studied extensively with regard to cell polarity and extracellular signaling. Less is known about the way in which signals and polarity cues integrate with intracellular structures to ensure appropriate niche organization and function. Here, we report that nuclear lamins function...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.05.003
更新日期:2013-07-03 00:00:00
abstract::Nodal and Activin belong to the TGF-β superfamily and are important regulators of embryonic stem cell fate. Here we investigated whether Nodal and Activin regulate self-renewal of pancreatic cancer stem cells. Nodal and Activin were hardly detectable in more differentiated pancreatic cancer cells, while cancer stem ce...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.10.001
更新日期:2011-11-04 00:00:00
abstract::Individuals with neurofibromatosis type 1 (NF1) develop abnormalities of both neuronal and glial cell lineages, suggesting that the NF1 protein neurofibromin is an essential regulator of neuroglial progenitor function. In this regard, Nf1-deficient embryonic telencephalic neurospheres exhibit increased self-renewal an...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2007.07.008
更新日期:2007-10-11 00:00:00
abstract::There is intense contemporary interest in the identity, stability, and potential of stem cells, in the body or in the lab. The unusually comprehensive view provided by the 7th annual meeting of the ISSCR provides a framework to summarize recent progress. ...
journal_title:Cell stem cell
pub_type:
doi:10.1016/j.stem.2009.10.012
更新日期:2009-11-06 00:00:00
abstract::Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in niches, which are anatomically distinct regions within the tumor microenvironment. These niches maintain the principle properties of...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2015.02.015
更新日期:2015-03-05 00:00:00
abstract::The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes. Despite recent publications of DNA sequence variations in the iPSCs, the true scope of such changes for the entire genome is not clear. Here we report the whole-g...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.01.005
更新日期:2012-03-02 00:00:00
abstract::Two independent studies by Li et al. (2010) and Samavarchi-Tehrani et al. (2010) in this issue of Cell Stem Cell suggest that a mesenchymal-to-epithelial transition is a critical initiating event during the derivation of induced pluripotent stem cells (iPSCs) from fibroblasts, indicating remarkable similarities betwee...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2010.05.018
更新日期:2010-07-02 00:00:00
abstract::How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2012.03.012
更新日期:2012-04-06 00:00:00
abstract::In a recent issue of Nature, Tachibana et al. (2009) conducted chromosomal transfer into recipient primate oocytes to yield live offspring or monkey ESCs with no contribution of donor mitochondria. The success of this technique may increase demand for human oocyte donation for research. ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.09.009
更新日期:2009-10-02 00:00:00
abstract::In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogen...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.11.013
更新日期:2019-01-03 00:00:00
abstract::The generation of human embryonic stem cell banking networks has ensured that well-characterized and quality controlled stem cell lines are broadly accessible to researchers worldwide. Here, we provide recommendations for engaging these established networks in efforts to build similar resources for the distribution an...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.09.007
更新日期:2013-10-03 00:00:00
abstract::The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular pathways essential for brain development and autoph...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.07.019
更新日期:2016-11-03 00:00:00
abstract::Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in huma...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.03.002
更新日期:2016-05-05 00:00:00
abstract::Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to ...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2009.03.005
更新日期:2009-04-03 00:00:00
abstract::Structural and transcriptional changes during early brain maturation follow fixed developmental programs defined by genetics. However, whether this is true for functional network activity remains unknown, primarily due to experimental inaccessibility of the initial stages of the living human brain. Here, we developed ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.08.002
更新日期:2019-10-03 00:00:00
abstract::The cellular identity of niche cells that regulate hematopoietic stem cell (HSC) self-renewal and differentiation has been debated for several years. Two recent studies in Nature (Ding and Morrison, 2013; Greenbaum et al., 2013) have shed light into the bone marrow stromal subsets making CXCL12, a chemokine critical f...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2013.03.012
更新日期:2013-04-04 00:00:00