Abstract：
:Stem cell niche interactions have been studied extensively with regard to cell polarity and extracellular signaling. Less is known about the way in which signals and polarity cues integrate with intracellular structures to ensure appropriate niche organization and function. Here, we report that nuclear lamins function in the cyst stem cells (CySCs) of Drosophila testes to control the interaction of CySCs with the hub. This interaction is important for regulation of CySC differentiation and organization of the niche that supports the germline stem cells (GSCs). Lamin promotes nuclear retention of phosphorylated ERK in the CySC lineage by regulating the distribution of specific nucleoporins within the nuclear pores. Lamin-regulated nuclear epidermal growth factor (EGF) receptor signaling in the CySC lineage is essential for proliferation and differentiation of the GSCs and the transient amplifying germ cells. Thus, we have uncovered a role for the nuclear lamina in the integration of EGF signaling to regulate stem cell niche function.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Chen H,Chen X,Zheng Ydoi
10.1016/j.stem.2013.05.003subject
Has Abstractpub_date
2013-07-03 00:00:00pages
73-86issue
1eissn
1934-5909issn
1875-9777pii
S1934-5909(13)00196-3journal_volume
13pub_type
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