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Mouse embryonic head as a site for hematopoietic stem cell development.

Abstract：

:In the mouse embryo, the aorta-gonad-mesonephros (AGM) region is considered to be the sole location for intraembryonic emergence of hematopoietic stem cells (HSCs). Here we report that, in parallel to the AGM region, the E10.5-E11.5 mouse head harbors bona fide HSCs, as defined by long-term, high-level, multilineage reconstitution and self-renewal capacity in adult recipients, before HSCs enter the circulation. The presence of hemogenesis in the midgestation head is indicated by the appearance of intravascular cluster cells and the blood-forming capacity of a sorted endothelial cell population. In addition, lineage tracing via an inducible VE-cadherin-Cre transgene demonstrates the hemogenic capacity of head endothelium. Most importantly, a spatially restricted lineage labeling system reveals the physiological contribution of cerebrovascular endothelium to postnatal HSCs and multilineage hematopoiesis. We conclude that the mouse embryonic head is a previously unappreciated site for HSC emergence within the developing embryo.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Li Z,Lan Y,He W,Chen D,Wang J,Zhou F,Wang Y,Sun H,Chen X,Xu C,Li S,Pang Y,Zhang G,Yang L,Zhu L,Fan M,Shang A,Ju Z,Luo L,Ding Y,Guo W,Yuan W,Yang X,Liu B

doi

10.1016/j.stem.2012.07.004

subject

Has Abstract

pub_date

2012-11-02 00:00:00

pages

663-75

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(12)00419-5

journal_volume

11

pub_type

杂志文章

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