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Clinical Translation of Pluripotent Stem Cell Therapies: Challenges and Considerations.

Abstract：

:Although the clinical outcomes of cell therapy trials have not met initial expectations, emerging evidence suggests that injury-mediated tissue damage might benefit from the delivery of cells or their secreted products. Pluripotent stem cells (PSCs) are promising cell sources primarily because of their capacity to generate stage- and lineage-specific differentiated derivatives. However, they carry inherent challenges for safe and efficacious clinical translation. This Review describes completed or ongoing trials of PSCs, discusses their potential mechanisms of action, and considers how to address the challenges required for them to become a major therapy, using heart repair as a case study.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Desgres M,Menasché P

doi

10.1016/j.stem.2019.10.001

subject

Has Abstract

pub_date

2019-11-07 00:00:00

pages

594-606

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(19)30422-9

journal_volume

25

pub_type

杂志文章,评审

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