Slow Your Roll: Inhibiting SETD7 Activity Permits Ex Vivo Expansion of Muscle Stem Cells.

Abstract:

:Muscle stem cell regenerative capacity is rapidly lost during ex vivo culture. In this issue of Cell Stem Cell, Judson et al. (2018) show that inhibition of cytoplasmic SETD7, a lysine methyltransferase, potently expands naive, undifferentiated mouse and human muscle stem cells by restricting their progression through the myogenic program.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Fujita R,Crist C

doi

10.1016/j.stem.2018.01.007

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

146-147

issue

2

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(18)30007-9

journal_volume

22

pub_type

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