当前位置： SCI文献检索 > Cell Stem Cell期刊下所有文献 > Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.

Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.

Abstract：

:Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute myocardial infarction (MI) to investigate the functional impact of intramyocardial transplantation of hiPSC-derived cardiomyocytes, endothelial cells, and smooth muscle cells, in combination with a 3D fibrin patch loaded with insulin growth factor (IGF)-encapsulated microspheres. hiPSC-derived cardiomyocytes integrated into host myocardium and generated organized sarcomeric structures, and endothelial and smooth muscle cells contributed to host vasculature. Trilineage cell transplantation significantly improved left ventricular function, myocardial metabolism, and arteriole density, while reducing infarct size, ventricular wall stress, and apoptosis without inducing ventricular arrhythmias. These findings in a large animal MI model highlight the potential of utilizing hiPSC-derived cells for cardiac repair.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Ye L,Chang YH,Xiong Q,Zhang P,Zhang L,Somasundaram P,Lepley M,Swingen C,Su L,Wendel JS,Guo J,Jang A,Rosenbush D,Greder L,Dutton JR,Zhang J,Kamp TJ,Kaufman DS,Ge Y,Zhang J

doi

10.1016/j.stem.2014.11.009

subject

Has Abstract

pub_date

2014-12-04 00:00:00

pages

750-61

issue

6

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(14)00521-9

journal_volume

15

pub_type

杂志文章

相关文献

Cell Stem Cell文献大全
  • More than One Way to Skin a Wound.

    abstract：:Large cutaneous and non-healing ulcers exhibit impaired epithelialization, which represents a major therapeutic challenge. Recently in Nature, Kurita et al. (2018) reported a surprising potential source of epithelial cells. The authors demonstrate that wound-resident mesenchymal cells can be reprogrammed to generate e...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2018.10.014

    authors： Ankawa R,Fuchs Y

    更新日期：2018-11-01 00:00:00

  • Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.

    abstract：:Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine dec...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2017.11.003

    authors： Chen X,Deng H,Churchill MJ,Luchsinger LL,Du X,Chu TH,Friedman RA,Middelhoff M,Ding H,Tailor YH,Wang ALE,Liu H,Niu Z,Wang H,Jiang Z,Renders S,Ho SH,Shah SV,Tishchenko P,Chang W,Swayne TC,Munteanu L,Califano A,

    更新日期：2017-12-07 00:00:00

  • Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs.

    abstract：:Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets d...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2015.04.009

    authors： Bogdanović O,Lister R

    更新日期：2015-05-07 00:00:00

  • Adult neural stem cells bridge their niche.

    abstract：:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2012.05.012

    authors： Fuentealba LC,Obernier K,Alvarez-Buylla A

    更新日期：2012-06-14 00:00:00

  • Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

    abstract：:Adoptive immunotherapy with functional T cells is potentially an effective therapeutic strategy for combating many types of cancer and viral infection. However, exhaustion of antigen-specific T cells represents a major challenge to this type of approach. In an effort to overcome this problem, we reprogrammed clonally ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2012.11.002

    authors： Nishimura T,Kaneko S,Kawana-Tachikawa A,Tajima Y,Goto H,Zhu D,Nakayama-Hosoya K,Iriguchi S,Uemura Y,Shimizu T,Takayama N,Yamada D,Nishimura K,Ohtaka M,Watanabe N,Takahashi S,Iwamoto A,Koseki H,Nakanishi M,Eto K,Na

    更新日期：2013-01-03 00:00:00

  • Kit regulates HSC engraftment across the human-mouse species barrier.

    abstract：:In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.06.001

    authors： Cosgun KN,Rahmig S,Mende N,Reinke S,Hauber I,Schäfer C,Petzold A,Weisbach H,Heidkamp G,Purbojo A,Cesnjevar R,Platz A,Bornhäuser M,Schmitz M,Dudziak D,Hauber J,Kirberg J,Waskow C

    更新日期：2014-08-07 00:00:00

  • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.

    abstract：:Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem cells (iPSCs) via exogenous transcription factors but the underlying mechanism is unclear. Here we show that the generation of iPSCs fro...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2010.04.014

    authors： Li R,Liang J,Ni S,Zhou T,Qing X,Li H,He W,Chen J,Li F,Zhuang Q,Qin B,Xu J,Li W,Yang J,Gan Y,Qin D,Feng S,Song H,Yang D,Zhang B,Zeng L,Lai L,Esteban MA,Pei D

    更新日期：2010-07-02 00:00:00

  • FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.

    abstract：:Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2012.05.027

    authors： Chu SH,Heiser D,Li L,Kaplan I,Collector M,Huso D,Sharkis SJ,Civin C,Small D

    更新日期：2012-09-07 00:00:00

  • Stem cell RNA epigenetics: m(6)arking your territory.

    abstract：:Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2014.11.011

    authors： Jalkanen AL,Wilusz J

    更新日期：2014-12-04 00:00:00

  • Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming.

    abstract：:Direct cellular reprogramming provides a powerful platform to study cell plasticity and dissect mechanisms underlying cell fate determination. Here, we report a single-cell transcriptomic study of human cardiac (hiCM) reprogramming that utilizes an analysis pipeline incorporating current data normalization methods, mu...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.05.020

    authors： Zhou Y,Liu Z,Welch JD,Gao X,Wang L,Garbutt T,Keepers B,Ma H,Prins JF,Shen W,Liu J,Qian L

    更新日期：2019-07-03 00:00:00

  • Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.

    abstract：:The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficientl...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2016.02.016

    authors： Tang H,Hammack C,Ogden SC,Wen Z,Qian X,Li Y,Yao B,Shin J,Zhang F,Lee EM,Christian KM,Didier RA,Jin P,Song H,Ming GL

    更新日期：2016-05-05 00:00:00

  • Evaluation of Stuart et al.: Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

    abstract：:An example of the peer review process for "Distinct molecular trajectories converge to induce naive pluripotency" (Stuart et al., 2019) is presented here. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2019.08.009

    authors： Stadtfeld M

    更新日期：2019-09-05 00:00:00

  • DNA-damage response in tissue-specific and cancer stem cells.

    abstract：:Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to a...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2010.12.012

    authors： Blanpain C,Mohrin M,Sotiropoulou PA,Passegué E

    更新日期：2011-01-07 00:00:00

  • The human egg is back.

    abstract：:In a recent issue of Nature, Tachibana et al. (2009) conducted chromosomal transfer into recipient primate oocytes to yield live offspring or monkey ESCs with no contribution of donor mitochondria. The success of this technique may increase demand for human oocyte donation for research. ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2009.09.009

    authors： Cibelli J

    更新日期：2009-10-02 00:00:00

  • Control of stem cell fate by physical interactions with the extracellular matrix.

    abstract：:A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at th...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2009.06.016

    authors： Guilak F,Cohen DM,Estes BT,Gimble JM,Liedtke W,Chen CS

    更新日期：2009-07-02 00:00:00

  • Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.

    abstract：:Long noncoding RNAs (lncRNAs) have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, we comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. We utilize complementary genome-wide techniques includin...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2013.03.003

    authors： Ramos AD,Diaz A,Nellore A,Delgado RN,Park KY,Gonzales-Roybal G,Oldham MC,Song JS,Lim DA

    更新日期：2013-05-02 00:00:00

  • Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells.

    abstract：:In this study, we explore endoderm cell fate regulation through the expression of lineage-determining transcription factors. We demonstrate that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm prog...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2008.06.018

    authors： Séguin CA,Draper JS,Nagy A,Rossant J

    更新日期：2008-08-07 00:00:00

  • New tools for genome modification in human embryonic stem cells.

    abstract：:Two recent papers outline improvements in gene editing technology that may facilitate the analysis of signaling networks important for development. The systems developed by both Thyagarajan and coworkers (Thyagarajan et al., 2007) in Nature Biotechnology, and Lombardo and colleagues (Lombardo et al., 2007) in Stem Cel...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2007.11.004

    authors： Ptaszek LM,Cowan CA

    更新日期：2007-12-13 00:00:00

  • Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos.

    abstract：:Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by reprogramming their nuclei to a totipotent state. However, successful full-term development of SCNT embryos is a low-efficiency process and arrested embryos frequently exhibit epigenetic abnormalities. Here, we generated genome-wide DNA me...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2018.07.017

    authors： Gao R,Wang C,Gao Y,Xiu W,Chen J,Kou X,Zhao Y,Liao Y,Bai D,Qiao Z,Yang L,Wang M,Zang R,Liu X,Jia Y,Li Y,Zhang Y,Yin J,Wang H,Wan X,Liu W,Zhang Y,Gao S

    更新日期：2018-09-06 00:00:00

  • A 3D Tissue-wide Digital Imaging Pipeline for Quantitation of Secreted Molecules Shows Absence of CXCL12 Gradients in Bone Marrow.

    abstract：:Technological limitations have hampered understanding of how individual molecules, including putative stem cell regulators, are distributed throughout tissues and stem cell niches. Here, we report adaptation of the proximity ligation assay (PLA) for large-volume, in situ imaging of individual proteins with multiple ad...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.10.003

    authors： Kunz L,Schroeder T

    更新日期：2019-12-05 00:00:00

  • The adult Drosophila malpighian tubules are maintained by multipotent stem cells.

    abstract：:All animals must excrete the waste products of metabolism. Excretion is performed by the kidney in vertebrates and by the Malpighian tubules in Drosophila. The mammalian kidney has an inherent ability for recovery and regeneration after ischemic injury. Stem cells and progenitor cells have been proposed to be responsi...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2007.07.003

    authors： Singh SR,Liu W,Hou SX

    更新日期：2007-08-16 00:00:00

  • Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis.

    abstract：:In this issue of Cell Stem Cell, Li et al. (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intestinal homeostasis through TEAD-dependent and -independent transcription. Loss of Lats1/2 mobilizes a previously unrecognized YAP/TAZ-Groucho/TLE interaction to suppress Wnt/TCF-mediated transcription, thereby...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2020.04.011

    authors： Fu V,Guan KL

    更新日期：2020-05-07 00:00:00

  • A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.

    abstract：:Cellular metabolism plays important functions in dictating stem cell behaviors, although its role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation. Administering the AMPK activator metformin d...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2020.03.006

    authors： Miao ZF,Adkins-Threats M,Burclaff JR,Osaki LH,Sun JX,Kefalov Y,He Z,Wang ZN,Mills JC

    更新日期：2020-06-04 00:00:00

  • Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells.

    abstract：:Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to ...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2009.03.005

    authors： Feng B,Ng JH,Heng JC,Ng HH

    更新日期：2009-04-03 00:00:00

  • Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

    abstract：:Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescen...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.12.011

    authors： Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA

    更新日期：2020-03-05 00:00:00

  • TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia.

    abstract：:An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenit...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2016.04.008

    authors： Tummala H,Dokal I

    更新日期：2016-05-05 00:00:00

  • Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells.

    abstract：:Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested that ESCs and iPSCs...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2010.06.015

    authors： Guenther MG,Frampton GM,Soldner F,Hockemeyer D,Mitalipova M,Jaenisch R,Young RA

    更新日期：2010-08-06 00:00:00

  • Targeting epigenetics to speed up repair.

    abstract：:In this issue of Cell Stem Cell, Palii et al. reveal that TAL1 is a master regulator of adhesion and migration networks in human endothelial progenitors and that ex vivo treatment with the histone deacetylase inhibitor TSA enables their faster vascularization after ischemic injury. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2014.04.018

    authors： Soler E,Grosveld F

    更新日期：2014-05-01 00:00:00

  • RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

    abstract：:N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be frequently deleted, implying a ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2020.04.009

    authors： Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

    更新日期：2020-07-02 00:00:00

  • The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?

    abstract：:Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in niches, which are anatomically distinct regions within the tumor microenvironment. These niches maintain the principle properties of...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2015.02.015

    authors： Plaks V,Kong N,Werb Z

    更新日期：2015-03-05 00:00:00