Abstract:
:Adipose stromal cells (ASCs) serve as mesenchymal progenitors in white adipose tissue (WAT). Intercellular interactions involving ASCs have remained obscure. By merging phage display technology with fluorescence-activated cell sorting (FACS), we screened a combinatorial library for peptides that target mouse ASCs in vivo. We isolated peptide CSWKYWFGEC that specifically homes to ASCs, used it as bait to purify the corresponding ASC surface receptor, and identified it as a previously unreported cleavage product of decorin (DCN) lacking the glycanation site (termed ΔDCN). We demonstrate that ΔDCN is differentially expressed on ASC surface. In a screen for ΔDCN-binding proteins, we identified resistin, an adipokine for which the receptor has been unknown. Expression of ΔDCN in 3T3-L1 cells promoted proliferation and migration but suppressed lipid accumulation upon adipogenesis induction, which was resistin dependent. We conclude that ΔDCN serves as a functional receptor of resistin in adipocyte progenitors and may regulate WAT expansion.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Daquinag AC,Zhang Y,Amaya-Manzanares F,Simmons PJ,Kolonin MGdoi
10.1016/j.stem.2011.05.017subject
Has Abstractpub_date
2011-07-08 00:00:00pages
74-86issue
1eissn
1934-5909issn
1875-9777pii
S1934-5909(11)00286-4journal_volume
9pub_type
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