Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics.

abstract：:Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding sequences. To investi...

journal_title：Cell stem cell

authors： Forrest MP,Zhang H,Moy W,McGowan H,Leites C,Dionisio LE,Xu Z,Shi J,Sanders AR,Greenleaf WJ,Cowan CA,Pang ZP,Gejman PV,Penzes P,Duan J

更新日期：2017-09-07 00:00:00

abstract：:How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells. ...

journal_title：Cell stem cell

authors： Shen H,Laird PW

更新日期：2012-04-06 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly effective treatments. Here, we describe a new small molecule survival screen carried out using MNs from both wild-type and mutant SOD1 mouse embryonic stem cell...

journal_title：Cell stem cell

authors： Yang YM,Gupta SK,Kim KJ,Powers BE,Cerqueira A,Wainger BJ,Ngo HD,Rosowski KA,Schein PA,Ackeifi CA,Arvanites AC,Davidow LS,Woolf CJ,Rubin LL

更新日期：2013-06-06 00:00:00

abstract：:Secreted frizzled-related protein 1 (Sfrp1) is highly expressed by stromal cells maintaining hematopoietic stem cells (HSCs). Sfrp1 loss in stromal cells increases production of hematopoietic progenitors, and in knockout mice, dysregulates hemostasis and increases Flk2- Cd34- Lin- Sca1+ Kit+ (LSK) cell numbers in bone...

journal_title：Cell stem cell

authors： Renström J,Istvanffy R,Gauthier K,Shimono A,Mages J,Jardon-Alvarez A,Kröger M,Schiemann M,Busch DH,Esposito I,Lang R,Peschel C,Oostendorp RA

更新日期：2009-08-07 00:00:00

abstract：:In homeostasis of adult vertebrate tissues, stem cells are thought to self-renew by infrequent and asymmetric divisions that generate another stem cell daughter and a progenitor daughter cell committed to differentiate. This model is based largely on in vivo invertebrate or in vitro mammal studies. Here, we examine th...

journal_title：Cell stem cell

authors： Zhang YV,Cheong J,Ciapurin N,McDermitt DJ,Tumbar T

更新日期：2009-09-04 00:00:00

abstract：:Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage female hiPSCs retain the inactive X chromosome of the somatic cell they are...

journal_title：Cell stem cell

authors： Mekhoubad S,Bock C,de Boer AS,Kiskinis E,Meissner A,Eggan K

更新日期：2012-05-04 00:00:00

abstract：:Adipocyte progenitors (APs) express platelet-derived growth factor receptors (PDGFRs), PDGFRα and PDGFRβ. Elevated PDGFRα signaling inhibits adipogenesis and promotes fibrosis; however, the function of PDGFRs in APs remains unclear. We combined lineage tracing and functional analyses in a sequential dual-recombinase a...

journal_title：Cell stem cell

authors： Sun C,Sakashita H,Kim J,Tang Z,Upchurch GM,Yao L,Berry WL,Griffin TM,Olson LE

更新日期：2020-05-07 00:00:00

abstract：:Mammalian embryonic stem cells (ESCs) can self-organize in vitro, but whether they can recreate early embryonic morphogenesis is unclear. Harrison et al. recently demonstrate in Science that 3D co-cultures of mouse ESCs and trophoblast stem cells self-organize into embryo-like structures that recreate many features of...

journal_title：Cell stem cell

authors： Warmflash A

更新日期：2017-05-04 00:00:00

abstract：:Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched) or commit to gametogenesis (Kit(+) enriched). To better understand how chromatin regulates AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylation, 5hmC, histone modifications/variants, and RNA-seq in AGSCs an...

journal_title：Cell stem cell

authors： Hammoud SS,Low DH,Yi C,Carrell DT,Guccione E,Cairns BR

更新日期：2014-08-07 00:00:00

abstract：:Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively. ...

journal_title：Cell stem cell

authors： Wood KC,Sabatini DM

更新日期：2009-09-04 00:00:00

abstract：:Intestinal organoids offer great promise for modeling intestinal diseases; however, harvesting intestinal tissue is invasive and directed hPSC differentiation protocols are laborious and costly. In this issue of Cell Stem Cell, Miura and Suzuki (2017) describe the direct conversion of somatic cells from both mice and ...

journal_title：Cell stem cell

authors： Nakauka-Ddamba A,Lengner CJ

更新日期：2017-10-05 00:00:00

abstract：:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...

journal_title：Cell stem cell

authors： Fuentealba LC,Obernier K,Alvarez-Buylla A

更新日期：2012-06-14 00:00:00

abstract：:Radiation is one of the most effective cancer treatments. However, gastrointestinal (GI) syndrome is a major limiting factor in abdominal and pelvic radiotherapy. The loss of crypt stem cells or villus endothelial cells has been suggested to be responsible for radiation-induced intestinal damage. We report here a crit...

journal_title：Cell stem cell

authors： Qiu W,Carson-Walter EB,Liu H,Epperly M,Greenberger JS,Zambetti GP,Zhang L,Yu J

更新日期：2008-06-05 00:00:00

abstract：:A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at th...

journal_title：Cell stem cell

authors： Guilak F,Cohen DM,Estes BT,Gimble JM,Liedtke W,Chen CS

更新日期：2009-07-02 00:00:00

abstract：:Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part, through the alternative splicing of self-renewal and survival genes. To elucidate splice-isoform regulators of human BC LSC maintena...

journal_title：Cell stem cell

authors： Goff DJ,Court Recart A,Sadarangani A,Chun HJ,Barrett CL,Krajewska M,Leu H,Low-Marchelli J,Ma W,Shih AY,Wei J,Zhai D,Geron I,Pu M,Bao L,Chuang R,Balaian L,Gotlib J,Minden M,Martinelli G,Rusert J,Dao KH,Shazand

更新日期：2013-03-07 00:00:00

abstract：:Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). However, this process is typically very inefficient, complicating mechanistic studies. We identified and molecularly characterized rare, early intermediates poised to reprogram with up to 95% efficiency, without perturbin...

journal_title：Cell stem cell

authors： Schwarz BA,Cetinbas M,Clement K,Walsh RM,Cheloufi S,Gu H,Langkabel J,Kamiya A,Schorle H,Meissner A,Sadreyev RI,Hochedlinger K

更新日期：2018-08-02 00:00:00

abstract：:Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unkn...

journal_title：Cell stem cell

authors： Laurenti E,Frelin C,Xie S,Ferrari R,Dunant CF,Zandi S,Neumann A,Plumb I,Doulatov S,Chen J,April C,Fan JB,Iscove N,Dick JE

更新日期：2015-03-05 00:00:00

abstract：:Renal pathology suggests that tubular repair results from tubular proliferation. In contrast, recent studies propose that postnatal kidney repair may involve renal stem cells. In this issue of Cell Stem Cell, Humphreys et al. (2008) use lineage tracing to genetically assess contribution of adult nontubular cells (pote...

journal_title：Cell stem cell

authors： Little MH

更新日期：2008-03-06 00:00:00

abstract：:To date, pluripotent epiblast stem cells (EpiSCs) had only been derived from postimplantation mouse embryos. In this issue of Cell Stem Cell, Najm et al. (2011) demonstrate that EpiSCs can be routinely derived from preimplantation embryos, showing that both human and mouse blastocysts can produce the same class of pri...

journal_title：Cell stem cell

authors： Kunath T

更新日期：2011-03-04 00:00:00

abstract：:Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not recapitulate critical myelination phenotypes and it is therefore not c...

journal_title：Cell stem cell

authors： Li L,Tian E,Chen X,Chao J,Klein J,Qu Q,Sun G,Sun G,Huang Y,Warden CD,Ye P,Feng L,Li X,Cui Q,Sultan A,Douvaras P,Fossati V,Sanjana NE,Riggs AD,Shi Y

更新日期：2018-08-02 00:00:00

abstract：:Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine dec...

journal_title：Cell stem cell

authors： Chen X,Deng H,Churchill MJ,Luchsinger LL,Du X,Chu TH,Friedman RA,Middelhoff M,Ding H,Tailor YH,Wang ALE,Liu H,Niu Z,Wang H,Jiang Z,Renders S,Ho SH,Shah SV,Tishchenko P,Chang W,Swayne TC,Munteanu L,Califano A,

更新日期：2017-12-07 00:00:00

abstract：:Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that...

journal_title：Cell stem cell

authors： Manley WF,Anderson SA

更新日期：2019-06-06 00:00:00

abstract：:Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...

journal_title：Cell stem cell

authors： Chu SH,Heiser D,Li L,Kaplan I,Collector M,Huso D,Sharkis SJ,Civin C,Small D

更新日期：2012-09-07 00:00:00

abstract：:Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has proven difficult. Here, we took a multifaceted approach to investigate why 15q11.2 copy number variants are prominent risk factors for schizophrenia and autism. Fir...

journal_title：Cell stem cell

authors： Yoon KJ,Nguyen HN,Ursini G,Zhang F,Kim NS,Wen Z,Makri G,Nauen D,Shin JH,Park Y,Chung R,Pekle E,Zhang C,Towe M,Hussaini SM,Lee Y,Rujescu D,St Clair D,Kleinman JE,Hyde TM,Krauss G,Christian KM,Rapoport JL,Wein

更新日期：2014-07-03 00:00:00

abstract：:Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescen...

journal_title：Cell stem cell

authors： Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA

更新日期：2020-03-05 00:00:00

abstract：:Cell cycle regulators play critical roles in the balance between hematopoietic stem cell (HSC) dormancy and proliferation. In this study, we report that cell cycle entry proceeded normally in HSCs null for cyclin-dependent kinase (CDK) inhibitor p57 due to compensatory upregulation of p27. HSCs null for both p57 and p...

journal_title：Cell stem cell

authors： Zou P,Yoshihara H,Hosokawa K,Tai I,Shinmyozu K,Tsukahara F,Maru Y,Nakayama K,Nakayama KI,Suda T

更新日期：2011-09-02 00:00:00

abstract：:Recurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromosome separation and DNA damage repair, cohesin complex functions during hemato...

journal_title：Cell stem cell

authors： Mazumdar C,Shen Y,Xavy S,Zhao F,Reinisch A,Li R,Corces MR,Flynn RA,Buenrostro JD,Chan SM,Thomas D,Koenig JL,Hong WJ,Chang HY,Majeti R

更新日期：2015-12-03 00:00:00

abstract：:Mouse embryonic stem cells (mESCs) cultured under serum/LIF conditions exhibit heterogeneous expression of pluripotency-associated factors that can be overcome by two inhibitors (2i) of the MEK and GSK3 pathways. Several studies have shown that the "ground state" induced by 2i is characterized by global hypomethylatio...

journal_title：Cell stem cell

authors： Galonska C,Ziller MJ,Karnik R,Meissner A

更新日期：2015-10-01 00:00:00

abstract：:Innate immune factors may restrict hematopoietic stem cell (HSC) genetic engineering and contribute to broad individual variability in gene therapy outcomes. Here, we show that HSCs harbor an early, constitutively active innate immune block to lentiviral transduction that can be efficiently overcome by cyclosporine H ...

journal_title：Cell stem cell

authors： Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

更新日期：2018-12-06 00:00:00

abstract：:All animals must excrete the waste products of metabolism. Excretion is performed by the kidney in vertebrates and by the Malpighian tubules in Drosophila. The mammalian kidney has an inherent ability for recovery and regeneration after ischemic injury. Stem cells and progenitor cells have been proposed to be responsi...

journal_title：Cell stem cell

authors： Singh SR,Liu W,Hou SX

更新日期：2007-08-16 00:00:00