Gut with the Program: Direct Reprogramming toward Intestinal Epithelium Realized.

Abstract:

:Intestinal organoids offer great promise for modeling intestinal diseases; however, harvesting intestinal tissue is invasive and directed hPSC differentiation protocols are laborious and costly. In this issue of Cell Stem Cell, Miura and Suzuki (2017) describe the direct conversion of somatic cells from both mice and humans into robust intestinal epithelial tissue.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Nakauka-Ddamba A,Lengner CJ

doi

10.1016/j.stem.2017.09.011

subject

Has Abstract

pub_date

2017-10-05 00:00:00

pages

417-418

issue

4

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(17)30378-8

journal_volume

21

pub_type

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    abstract::To date, pluripotent epiblast stem cells (EpiSCs) had only been derived from postimplantation mouse embryos. In this issue of Cell Stem Cell, Najm et al. (2011) demonstrate that EpiSCs can be routinely derived from preimplantation embryos, showing that both human and mouse blastocysts can produce the same class of pri...

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