TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia.

Abstract:

:An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenitor cell survival.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Tummala H,Dokal I

doi

10.1016/j.stem.2016.04.008

subject

Has Abstract

pub_date

2016-05-05 00:00:00

pages

567-8

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(16)30051-0

journal_volume

18

pub_type

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