Abstract:
:An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenitor cell survival.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Tummala H,Dokal Idoi
10.1016/j.stem.2016.04.008subject
Has Abstractpub_date
2016-05-05 00:00:00pages
567-8issue
5eissn
1934-5909issn
1875-9777pii
S1934-5909(16)30051-0journal_volume
18pub_type
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