Abstract：
:Bmi1 is required for efficient self-renewal of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). In this study, we investigated whether leukemia-associated fusion proteins, which differ in their ability to activate Hox expression, could initiate leukemia in the absence of Bmi1. AML1-ETO and PLZF-RARα, which do not activate Hox, triggered senescence in Bmi1(-/-) cells. In contrast, MLL-AF9, which drives expression of Hoxa7 and Hoxa9, readily transformed Bmi1(-/-) cells. MLL-AF9 could not initiate leukemia in Bmi1(-/-)Hoxa9(-/-) mice, which have further compromised HSC functions. But either gene could restore the ability of MLL-AF9 to establish LSCs in the double null background. As reported for Bmi1, Hoxa9 regulates expression of p16(Ink4a)/p19(ARF) locus and could overcome senescence induced by AML1-ETO. Together, these results reveal an important functional interplay between MLL/Hox and Bmi1 in regulating cellular senescence for LSC development, suggesting that a synergistic targeting of both molecules is required to eradicate a broader spectrum of LSCs.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Smith LL,Yeung J,Zeisig BB,Popov N,Huijbers I,Barnes J,Wilson AJ,Taskesen E,Delwel R,Gil J,Van Lohuizen M,So CWdoi
10.1016/j.stem.2011.05.004subject
Has Abstractpub_date
2011-06-03 00:00:00pages
649-62issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(11)00224-4journal_volume
8pub_type
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