Looking Back: Cancer Stem Cells.

Abstract:

:Over the past decade, our growing understanding of cancer stem cell characteristics and function continues to guide innovative new treatments to eradicate cancer. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about the broad influences these studies have had.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

doi

10.1016/j.stem.2017.05.005

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

754

issue

6

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(17)30170-4

journal_volume

20

pub_type

评论,杂志文章
  • Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.

    abstract::Individuals with neurofibromatosis type 1 (NF1) develop abnormalities of both neuronal and glial cell lineages, suggesting that the NF1 protein neurofibromin is an essential regulator of neuroglial progenitor function. In this regard, Nf1-deficient embryonic telencephalic neurospheres exhibit increased self-renewal an...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2007.07.008

    authors: Hegedus B,Dasgupta B,Shin JE,Emnett RJ,Hart-Mahon EK,Elghazi L,Bernal-Mizrachi E,Gutmann DH

    更新日期:2007-10-11 00:00:00

  • Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML.

    abstract::Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages o...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.01.004

    authors: Gibbs KD Jr,Jager A,Crespo O,Goltsev Y,Trejo A,Richard CE,Nolan GP

    更新日期:2012-02-03 00:00:00

  • Kit regulates HSC engraftment across the human-mouse species barrier.

    abstract::In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2014.06.001

    authors: Cosgun KN,Rahmig S,Mende N,Reinke S,Hauber I,Schäfer C,Petzold A,Weisbach H,Heidkamp G,Purbojo A,Cesnjevar R,Platz A,Bornhäuser M,Schmitz M,Dudziak D,Hauber J,Kirberg J,Waskow C

    更新日期:2014-08-07 00:00:00

  • Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells.

    abstract::In this study, we explore endoderm cell fate regulation through the expression of lineage-determining transcription factors. We demonstrate that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm prog...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2008.06.018

    authors: Séguin CA,Draper JS,Nagy A,Rossant J

    更新日期:2008-08-07 00:00:00

  • From Skin to Brain: A Parkinson's Disease Patient Transplanted with His Own Cells.

    abstract::In a pioneering study in New England Journal of Medicine, Schweitzer et al. (2020) report on a patient with Parkinson's disease who received a graft of dopamine neurons obtained from in vitro differentiated induced pluripotent stem cells, derived from the patient's own skin fibroblasts, showing the feasibility of auto...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2020.06.008

    authors: Parmar M,Björklund A

    更新日期:2020-07-02 00:00:00

  • TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.

    abstract::Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in huma...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2016.03.002

    authors: Zhang H,Kozono DE,O'Connor KW,Vidal-Cardenas S,Rousseau A,Hamilton A,Moreau L,Gaudiano EF,Greenberger J,Bagby G,Soulier J,Grompe M,Parmar K,D'Andrea AD

    更新日期:2016-05-05 00:00:00

  • Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.

    abstract::Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide range of clinical phenotypes that include neonatal and adult-onset diabetes using CRISPR (clustere...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2017.01.001

    authors: Shi ZD,Lee K,Yang D,Amin S,Verma N,Li QV,Zhu Z,Soh CL,Kumar R,Evans T,Chen S,Huangfu D

    更新日期:2017-05-04 00:00:00

  • Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells.

    abstract::In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 genes. We were able to predict causal variants for these expression quantitative trait loci (e...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2017.03.009

    authors: DeBoever C,Li H,Jakubosky D,Benaglio P,Reyna J,Olson KM,Huang H,Biggs W,Sandoval E,D'Antonio M,Jepsen K,Matsui H,Arias A,Ren B,Nariai N,Smith EN,D'Antonio-Chronowska A,Farley EK,Frazer KA

    更新日期:2017-04-06 00:00:00

  • Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.

    abstract::Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2009.10.003

    authors: Sun B,Halabisky B,Zhou Y,Palop JJ,Yu G,Mucke L,Gan L

    更新日期:2009-12-04 00:00:00

  • Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary.

    abstract::Rapid progress has recently been made regarding how the niche controls stem cell function, but little is yet known about how stem cells in the same niche interact with one another. In this study, we show that differentiation-defective Drosophila ovarian germline stem cells (GSCs) can outcompete normal ones for niche o...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2007.10.021

    authors: Jin Z,Kirilly D,Weng C,Kawase E,Song X,Smith S,Schwartz J,Xie T

    更新日期:2008-01-10 00:00:00

  • Pluripotent stem cells from cloned human embryos: success at long last.

    abstract::Recently in Cell, Mitalipov and colleagues report an advance that has eluded scientists for over a decade-the successful derivation of embryonic stem cell lines using somatic cell nuclear transfer, or SCNT (Tachibana et al., 2013). ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2013.05.022

    authors: Trounson A,DeWitt ND

    更新日期:2013-06-06 00:00:00

  • Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.

    abstract::We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by a single neural transcription factor, NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrate that sequentia...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2015.09.012

    authors: Zhang L,Yin JC,Yeh H,Ma NX,Lee G,Chen XA,Wang Y,Lin L,Chen L,Jin P,Wu GY,Chen G

    更新日期:2015-12-03 00:00:00

  • Banking human induced pluripotent stem cells: lessons learned from embryonic stem cells?

    abstract::The generation of human embryonic stem cell banking networks has ensured that well-characterized and quality controlled stem cell lines are broadly accessible to researchers worldwide. Here, we provide recommendations for engaging these established networks in efforts to build similar resources for the distribution an...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2013.09.007

    authors: Stacey GN,Crook JM,Hei D,Ludwig T

    更新日期:2013-10-03 00:00:00

  • Stem cells by the sea.

    abstract::The 2009 ISSCR Annual Meeting in Barcelona will draw stem cell scientists from around the world to Europe, to connect to each other and to the local community. With record abstract submissions, we are sure to have an exciting meeting. ...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2009.05.009

    authors: McKay RD

    更新日期:2009-06-05 00:00:00

  • Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design.

    abstract::New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ul...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2016.12.003

    authors: Lipsitz YY,Bedford P,Davies AH,Timmins NE,Zandstra PW

    更新日期:2017-01-05 00:00:00

  • Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.

    abstract::Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has proven difficult. Here, we took a multifaceted approach to investigate why 15q11.2 copy number variants are prominent risk factors for schizophrenia and autism. Fir...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2014.05.003

    authors: Yoon KJ,Nguyen HN,Ursini G,Zhang F,Kim NS,Wen Z,Makri G,Nauen D,Shin JH,Park Y,Chung R,Pekle E,Zhang C,Towe M,Hussaini SM,Lee Y,Rujescu D,St Clair D,Kleinman JE,Hyde TM,Krauss G,Christian KM,Rapoport JL,Wein

    更新日期:2014-07-03 00:00:00

  • Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.

    abstract::The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular pathways essential for brain development and autoph...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2016.07.019

    authors: Liang Q,Luo Z,Zeng J,Chen W,Foo SS,Lee SA,Ge J,Wang S,Goldman SA,Zlokovic BV,Zhao Z,Jung JU

    更新日期:2016-11-03 00:00:00

  • Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.

    abstract::Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.06.012

    authors: Stone NR,Gifford CA,Thomas R,Pratt KJB,Samse-Knapp K,Mohamed TMA,Radzinsky EM,Schricker A,Ye L,Yu P,van Bemmel JG,Ivey KN,Pollard KS,Srivastava D

    更新日期:2019-07-03 00:00:00

  • Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development.

    abstract::Animal cloning can be achieved through somatic cell nuclear transfer (SCNT), although the live birth rate is relatively low. Recent studies have identified H3K9me3 in donor cells and abnormal Xist activation as epigenetic barriers that impede SCNT. Here we overcome these barriers using a combination of Xist knockout d...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.06.008

    authors: Matoba S,Wang H,Jiang L,Lu F,Iwabuchi KA,Wu X,Inoue K,Yang L,Press W,Lee JT,Ogura A,Shen L,Zhang Y

    更新日期:2018-09-06 00:00:00

  • Won't You Be My Neighbor? Muscle Stem Cells Recruit Endothelial Cells to Their Niche.

    abstract::The maintenance of a pool of quiescent satellite cells (muscle stem cells) is necessary for long-term muscle health. In this issue of Cell Stem Cell, Verma et al. (2018) show that satellite cells recruit endothelial cells to create a vascular niche and that cross-talk between endothelial and satellite cells is vital f...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2018.09.013

    authors: Collins BC,Kardon G

    更新日期:2018-10-04 00:00:00

  • Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK.

    abstract::In response to muscle injury, satellite cells activate the p38α/β MAPK pathway to exit quiescence, then proliferate, repair skeletal muscle, and self-renew, replenishing the quiescent satellite cell pool. Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite cell self-renewal...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.05.025

    authors: Troy A,Cadwallader AB,Fedorov Y,Tyner K,Tanaka KK,Olwin BB

    更新日期:2012-10-05 00:00:00

  • Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.

    abstract::Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2017.09.014

    authors: Barker RA,Parmar M,Studer L,Takahashi J

    更新日期:2017-11-02 00:00:00

  • High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

    abstract::Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation. Here, we present a fully automated, HTS-compatible platform for enhanced differentiation and...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.04.022

    authors: Czerniecki SM,Cruz NM,Harder JL,Menon R,Annis J,Otto EA,Gulieva RE,Islas LV,Kim YK,Tran LM,Martins TJ,Pippin JW,Fu H,Kretzler M,Shankland SJ,Himmelfarb J,Moon RT,Paragas N,Freedman BS

    更新日期:2018-06-01 00:00:00

  • Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis.

    abstract::Adipocyte progenitors (APs) express platelet-derived growth factor receptors (PDGFRs), PDGFRα and PDGFRβ. Elevated PDGFRα signaling inhibits adipogenesis and promotes fibrosis; however, the function of PDGFRs in APs remains unclear. We combined lineage tracing and functional analyses in a sequential dual-recombinase a...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2020.03.004

    authors: Sun C,Sakashita H,Kim J,Tang Z,Upchurch GM,Yao L,Berry WL,Griffin TM,Olson LE

    更新日期:2020-05-07 00:00:00

  • Reprogramming can be a transforming experience.

    abstract::Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2014.02.003

    authors: Hobbs RM,Polo JM

    更新日期:2014-03-06 00:00:00

  • IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy.

    abstract::Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2015.09.008

    authors: Cheng CW,Yilmaz ÖH

    更新日期:2015-10-01 00:00:00

  • Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.

    abstract::In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogen...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.11.013

    authors: Kitadate Y,Jörg DJ,Tokue M,Maruyama A,Ichikawa R,Tsuchiya S,Segi-Nishida E,Nakagawa T,Uchida A,Kimura-Yoshida C,Mizuno S,Sugiyama F,Azami T,Ema M,Noda C,Kobayashi S,Matsuo I,Kanai Y,Nagasawa T,Sugimoto Y,Takahashi

    更新日期:2019-01-03 00:00:00

  • Stem cells in 2009.

    abstract::There is intense contemporary interest in the identity, stability, and potential of stem cells, in the body or in the lab. The unusually comprehensive view provided by the 7th annual meeting of the ISSCR provides a framework to summarize recent progress. ...

    journal_title:Cell stem cell

    pub_type:

    doi:10.1016/j.stem.2009.10.012

    authors: McKay RD,van der Kooy D,Zwaka TP,Lin H

    更新日期:2009-11-06 00:00:00

  • Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells.

    abstract::In homeostasis of adult vertebrate tissues, stem cells are thought to self-renew by infrequent and asymmetric divisions that generate another stem cell daughter and a progenitor daughter cell committed to differentiate. This model is based largely on in vivo invertebrate or in vitro mammal studies. Here, we examine th...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2009.06.004

    authors: Zhang YV,Cheong J,Ciapurin N,McDermitt DJ,Tumbar T

    更新日期:2009-09-04 00:00:00

  • Evaluation of Stuart et al.: Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

    abstract::An example of the peer review process for "Distinct molecular trajectories converge to induce naive pluripotency" (Stuart et al., 2019) is presented here. ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2019.08.009

    authors: Stadtfeld M

    更新日期:2019-09-05 00:00:00