Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.

Abstract:

:In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogenic stem cell density is tightly regulated by the supply of fibroblast growth factors (FGFs) from lymphatic endothelial cells. We propose that stem cell homeostasis is achieved through competition for a limited supply of FGFs. We show that the quantitative dependence of stem cell density on FGF dosage, the biased localization of stem cells toward FGF sources, and stem cell dynamics during regeneration following injury can all be predicted and explained within the framework of a minimal theoretical model based on "mitogen competition." We propose that this model provides a generic and robust mechanism to support stem cell homeostasis in open, or facultative, niche environments.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Kitadate Y,Jörg DJ,Tokue M,Maruyama A,Ichikawa R,Tsuchiya S,Segi-Nishida E,Nakagawa T,Uchida A,Kimura-Yoshida C,Mizuno S,Sugiyama F,Azami T,Ema M,Noda C,Kobayashi S,Matsuo I,Kanai Y,Nagasawa T,Sugimoto Y,Takahashi

doi

10.1016/j.stem.2018.11.013

subject

Has Abstract

pub_date

2019-01-03 00:00:00

pages

79-92.e6

issue

1

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(18)30549-6

journal_volume

24

pub_type

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