Abstract：
:In homeostasis of adult vertebrate tissues, stem cells are thought to self-renew by infrequent and asymmetric divisions that generate another stem cell daughter and a progenitor daughter cell committed to differentiate. This model is based largely on in vivo invertebrate or in vitro mammal studies. Here, we examine the dynamic behavior of adult hair follicle stem cells in their normal setting by employing mice with repressible H2B-GFP expression to track cell divisions and Cre-inducible mice to perform long-term single-cell lineage tracing. We provide direct evidence for the infrequent stem cell division model in intact tissue. Moreover, we find that differentiation of progenitor cells occurs at different times and tissue locations than self-renewal of stem cells. Distinct fates of differentiation or self-renewal are assigned to individual cells in a temporal-spatial manner. We propose that large clusters of tissue stem cells behave as populations whose maintenance involves unidirectional daughter-cell-fate decisions.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Zhang YV,Cheong J,Ciapurin N,McDermitt DJ,Tumbar Tdoi
10.1016/j.stem.2009.06.004subject
Has Abstractpub_date
2009-09-04 00:00:00pages
267-78issue
3eissn
1934-5909issn
1875-9777pii
S1934-5909(09)00288-4journal_volume
5pub_type
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