Stem cells go soft: pliant substrate surfaces enhance motor neuron differentiation.

Abstract:

:Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Wang N

doi

10.1016/j.stem.2014.05.007

subject

Has Abstract

pub_date

2014-06-05 00:00:00

pages

701-3

issue

6

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(14)00194-5

journal_volume

14

pub_type

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