Abstract：
:Cell engineering has brought us tantalizingly close to the goal of deriving patient-specific hematopoietic stem cells (HSCs). While directed differentiation and transcription factor-mediated conversion strategies have generated progenitor cells with multilineage potential, to date, therapy-grade engineered HSCs remain elusive due to insufficient long-term self-renewal and inadequate differentiated progeny functionality. A cross-species approach involving zebrafish and mammalian systems offers complementary methodologies to improve understanding of native HSCs. Here, we discuss the role of conserved developmental timing processes in vertebrate hematopoiesis, highlighting how identification and manipulation of stage-specific factors that specify HSC developmental state must be harnessed to engineer HSCs for therapy.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Rowe RG,Mandelbaum J,Zon LI,Daley GQdoi
10.1016/j.stem.2016.05.016subject
Has Abstractpub_date
2016-06-02 00:00:00pages
707-720issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(16)30100-Xjournal_volume
18pub_type
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