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Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

Abstract：

:Adoptive immunotherapy with functional T cells is potentially an effective therapeutic strategy for combating many types of cancer and viral infection. However, exhaustion of antigen-specific T cells represents a major challenge to this type of approach. In an effort to overcome this problem, we reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to pluripotency. The T cell-derived induced pluripotent stem cells were then redifferentiated into CD8(+) T cells that had a high proliferative capacity and elongated telomeres. These "rejuvenated" cells possessed antigen-specific killing activity and exhibited T cell receptor gene-rearrangement patterns identical to those of the original T cell clone from the patient. We also found that this method can be effective for generating specific T cells for other pathology-associated antigens. Thus, this type of approach may have broad applications in the field of adoptive immunotherapy.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Nishimura T,Kaneko S,Kawana-Tachikawa A,Tajima Y,Goto H,Zhu D,Nakayama-Hosoya K,Iriguchi S,Uemura Y,Shimizu T,Takayama N,Yamada D,Nishimura K,Ohtaka M,Watanabe N,Takahashi S,Iwamoto A,Koseki H,Nakanishi M,Eto K,Na

doi

10.1016/j.stem.2012.11.002

subject

Has Abstract

pub_date

2013-01-03 00:00:00

pages

114-26

issue

1

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(12)00636-4

journal_volume

12

pub_type

杂志文章

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