当前位置： SCI文献检索 > Cell Stem Cell期刊下所有文献 > Home is where the heart is: via the FROUNT.

Home is where the heart is: via the FROUNT.

Abstract：

:In this issue of Cell Stem Cell, Belema-Bedada et al. (2008) describe a novel mechanism by which bone marrow-derived adult mesenchymal stem cells migrate to sites of damaged heart tissue. This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Zannettino AC,Psaltis PJ,Gronthos S

doi

10.1016/j.stem.2008.05.012

subject

Has Abstract

pub_date

2008-06-05 00:00:00

pages

513-4

issue

6

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(08)00226-9

journal_volume

2

pub_type

评论

相关文献

Cell Stem Cell文献大全
  • Single-Cell Transcriptomics Meets Lineage Tracing.

    abstract：:Reconstructing lineage relationships between cells within a tissue or organism is a long-standing aim in biology. Traditionally, lineage tracing has been achieved through the (genetic) labeling of a cell followed by the tracking of its offspring. Currently, lineage trajectories can also be predicted using single-cell ...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2018.04.014

    authors： Kester L,van Oudenaarden A

    更新日期：2018-08-02 00:00:00

  • Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.

    abstract：:In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogen...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2018.11.013

    authors： Kitadate Y,Jörg DJ,Tokue M,Maruyama A,Ichikawa R,Tsuchiya S,Segi-Nishida E,Nakagawa T,Uchida A,Kimura-Yoshida C,Mizuno S,Sugiyama F,Azami T,Ema M,Noda C,Kobayashi S,Matsuo I,Kanai Y,Nagasawa T,Sugimoto Y,Takahashi

    更新日期：2019-01-03 00:00:00

  • dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.

    abstract：:Regeneration of skin and hair follicles after wounding--a process known as wound-induced hair neogenesis (WIHN)--is a rare example of adult organogenesis in mammals. As such, WIHN provides a unique model system for deciphering mechanisms underlying mammalian regeneration. Here, we show that dsRNA, which is released fr...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2015.07.008

    authors： Nelson AM,Reddy SK,Ratliff TS,Hossain MZ,Katseff AS,Zhu AS,Chang E,Resnik SR,Page C,Kim D,Whittam AJ,Miller LS,Garza LA

    更新日期：2015-08-06 00:00:00

  • Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.

    abstract：:Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.06.012

    authors： Stone NR,Gifford CA,Thomas R,Pratt KJB,Samse-Knapp K,Mohamed TMA,Radzinsky EM,Schricker A,Ye L,Yu P,van Bemmel JG,Ivey KN,Pollard KS,Srivastava D

    更新日期：2019-07-03 00:00:00

  • Tracing the life of the kidney tubule- re-establishing dogma and redirecting the options.

    abstract：:Renal pathology suggests that tubular repair results from tubular proliferation. In contrast, recent studies propose that postnatal kidney repair may involve renal stem cells. In this issue of Cell Stem Cell, Humphreys et al. (2008) use lineage tracing to genetically assess contribution of adult nontubular cells (pote...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2008.02.007

    authors： Little MH

    更新日期：2008-03-06 00:00:00

  • An epigenomic road map for endoderm development.

    abstract：:While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives p...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2015.03.006

    authors： Kaestner KH

    更新日期：2015-04-02 00:00:00

  • Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts.

    abstract：:Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2019.05.009

    authors： Manley WF,Anderson SA

    更新日期：2019-06-06 00:00:00

  • Different levels of Twist1 regulate skin tumor initiation, stemness, and progression.

    abstract：:Twist1 promotes epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and cancer stem cell (CSC) properties. However, it remains unclear whether Twist1 is also required for tumor initiation and whether Twist1-induced cancer stemness and EMT are functionally linked. Using a conditional deletion of Twist1 at...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.12.002

    authors： Beck B,Lapouge G,Rorive S,Drogat B,Desaedelaere K,Delafaille S,Dubois C,Salmon I,Willekens K,Marine JC,Blanpain C

    更新日期：2015-01-08 00:00:00

  • Growth signaling at the nexus of stem cell life and death.

    abstract：:Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2009.08.008

    authors： Wood KC,Sabatini DM

    更新日期：2009-09-04 00:00:00

  • Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.

    abstract：:Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently because the injected cells undergo apoptosis. Here we show that transient promotion of cell survival through expression of the anti-apoptot...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2016.10.013

    authors： Masaki H,Kato-Itoh M,Takahashi Y,Umino A,Sato H,Ito K,Yanagida A,Nishimura T,Yamaguchi T,Hirabayashi M,Era T,Loh KM,Wu SM,Weissman IL,Nakauchi H

    更新日期：2016-11-03 00:00:00

  • RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.

    abstract：:RNA-binding proteins (RBPs), in addition to their functions in cellular homeostasis, play important roles in lineage specification and maintaining cellular identity. Despite their diverse and essential functions, which touch on nearly all aspects of RNA metabolism, the roles of RBPs in somatic cell reprogramming are p...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2016.12.002

    authors： Li H,Lai P,Jia J,Song Y,Xia Q,Huang K,He N,Ping W,Chen J,Yang Z,Li J,Yao M,Dong X,Zhao J,Hou C,Esteban MA,Gao S,Pei D,Hutchins AP,Yao H

    更新日期：2017-04-06 00:00:00

  • Kit regulates HSC engraftment across the human-mouse species barrier.

    abstract：:In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.06.001

    authors： Cosgun KN,Rahmig S,Mende N,Reinke S,Hauber I,Schäfer C,Petzold A,Weisbach H,Heidkamp G,Purbojo A,Cesnjevar R,Platz A,Bornhäuser M,Schmitz M,Dudziak D,Hauber J,Kirberg J,Waskow C

    更新日期：2014-08-07 00:00:00

  • GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease.

    abstract：:Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not recapitulate critical myelination phenotypes and it is therefore not c...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2018.07.009

    authors： Li L,Tian E,Chen X,Chao J,Klein J,Qu Q,Sun G,Sun G,Huang Y,Warden CD,Ye P,Feng L,Li X,Cui Q,Sultan A,Douvaras P,Fossati V,Sanjana NE,Riggs AD,Shi Y

    更新日期：2018-08-02 00:00:00

  • Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression.

    abstract：:The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes. Despite recent publications of DNA sequence variations in the iPSCs, the true scope of such changes for the entire genome is not clear. Here we report the whole-g...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2012.01.005

    authors： Cheng L,Hansen NF,Zhao L,Du Y,Zou C,Donovan FX,Chou BK,Zhou G,Li S,Dowey SN,Ye Z,NISC Comparative Sequencing Program.,Chandrasekharappa SC,Yang H,Mullikin JC,Liu PP

    更新日期：2012-03-02 00:00:00

  • Stem cell regulation and host defense: the logic and the paradox.

    abstract：:As a response against serious infection, there is often a need to produce more leukocytes to defend the organism against the infectious agent. In this issue of Cell Stem Cell, Goodell and colleagues (Feng et al., 2008) find a link between regulators of host defense and hematopoietic stem cells. ...

    journal_title：Cell stem cell

    pub_type： 评论,社论

    doi：10.1016/j.stem.2007.12.002

    authors： Karlsson G,Karlsson S

    更新日期：2008-01-10 00:00:00

  • Fate restriction and multipotency in retinal stem cells.

    abstract：:Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the fish retina and foll...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2011.11.004

    authors： Centanin L,Hoeckendorf B,Wittbrodt J

    更新日期：2011-12-02 00:00:00

  • Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells.

    abstract：:Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to ...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2009.03.005

    authors： Feng B,Ng JH,Heng JC,Ng HH

    更新日期：2009-04-03 00:00:00

  • Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.

    abstract：:Recurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromosome separation and DNA damage repair, cohesin complex functions during hemato...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2015.09.017

    authors： Mazumdar C,Shen Y,Xavy S,Zhao F,Reinisch A,Li R,Corces MR,Flynn RA,Buenrostro JD,Chan SM,Thomas D,Koenig JL,Hong WJ,Chang HY,Majeti R

    更新日期：2015-12-03 00:00:00

  • Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.

    abstract：:Long noncoding RNAs (lncRNAs) have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, we comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. We utilize complementary genome-wide techniques includin...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2013.03.003

    authors： Ramos AD,Diaz A,Nellore A,Delgado RN,Park KY,Gonzales-Roybal G,Oldham MC,Song JS,Lim DA

    更新日期：2013-05-02 00:00:00

  • Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells.

    abstract：:About half of the human genome consists of highly repetitive elements, most of which are considered dispensable for human life. Here, we report that repetitive elements originating from endogenous retroviruses (ERVs) are systematically transcribed during human early embryogenesis in a stage-specific manner. Our analys...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2015.01.005

    authors： Göke J,Lu X,Chan YS,Ng HH,Ly LH,Sachs F,Szczerbinska I

    更新日期：2015-02-05 00:00:00

  • Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML.

    abstract：:Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages o...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2012.01.004

    authors： Gibbs KD Jr,Jager A,Crespo O,Goltsev Y,Trejo A,Richard CE,Nolan GP

    更新日期：2012-02-03 00:00:00

  • Stress Can Be a Good Thing for Blood Formation.

    abstract：:Like politics, most developmental signals are local. However, in this issue of Cell Stem Cell, Kwan et al. (2016) and colleagues describe how a stress-induced signal that originates in the zebrafish brain promotes the formation of blood at a distant site, the dorsal aorta. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2016.08.011

    authors： Speck NA

    更新日期：2016-09-01 00:00:00

  • TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia.

    abstract：:An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenit...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2016.04.008

    authors： Tummala H,Dokal I

    更新日期：2016-05-05 00:00:00

  • Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells.

    abstract：:Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of photoreceptors in age-related macular degeneration and subtypes of retinitis pigmentosa. Human embryonic stem cells (hESCs) may serve as an unlimited source of RPE cells for transplantation in these blinding conditions. Here we show the ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2009.07.002

    authors： Idelson M,Alper R,Obolensky A,Ben-Shushan E,Hemo I,Yachimovich-Cohen N,Khaner H,Smith Y,Wiser O,Gropp M,Cohen MA,Even-Ram S,Berman-Zaken Y,Matzrafi L,Rechavi G,Banin E,Reubinoff B

    更新日期：2009-10-02 00:00:00

  • Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.

    abstract：:Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2009.10.003

    authors： Sun B,Halabisky B,Zhou Y,Palop JJ,Yu G,Mucke L,Gan L

    更新日期：2009-12-04 00:00:00

  • RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

    abstract：:N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be frequently deleted, implying a ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2020.04.009

    authors： Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

    更新日期：2020-07-02 00:00:00

  • Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

    abstract：:Innate immune factors may restrict hematopoietic stem cell (HSC) genetic engineering and contribute to broad individual variability in gene therapy outcomes. Here, we show that HSCs harbor an early, constitutively active innate immune block to lentiviral transduction that can be efficiently overcome by cyclosporine H ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2018.10.008

    authors： Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

    更新日期：2018-12-06 00:00:00

  • Sowing the Seeds of Clonal Hematopoiesis.

    abstract：:As humans age, hematopoietic stem cells (HSCs) occasionally acquire mutations in genes including DNMT3A that enable them to outcompete other HSCs and increase leukemia risk. In this issue of Cell Stem Cell, Tovy et al. (2020) report a previously uncharacterized mechanism by which DNMT3A loss confers increased fitness ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2020.07.011

    authors： Liggett LA,Voit RA,Sankaran VG

    更新日期：2020-08-06 00:00:00

  • An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells.

    abstract：:Adipose stromal cells (ASCs) serve as mesenchymal progenitors in white adipose tissue (WAT). Intercellular interactions involving ASCs have remained obscure. By merging phage display technology with fluorescence-activated cell sorting (FACS), we screened a combinatorial library for peptides that target mouse ASCs in v...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2011.05.017

    authors： Daquinag AC,Zhang Y,Amaya-Manzanares F,Simmons PJ,Kolonin MG

    更新日期：2011-07-08 00:00:00

  • AMPK Keeps Tumor Cells from Starving to Death.

    abstract：:In this issue of Cell Stem Cell, Saito et al. (2015) examine how leukemia-initiating cells react to metabolic stress imposed by different tissue environments. They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged glucose metabolism and redox homeostasis, resulting...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2015.10.007

    authors： Shaw RJ

    更新日期：2015-11-05 00:00:00