Abstract：
:Cellular metabolism plays important functions in dictating stem cell behaviors, although its role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation. Administering the AMPK activator metformin decreases epithelial progenitor proliferation and increases acid-secreting parietal cells (PCs) in mice and organoids. AMPK activation targets Krüppel-like factor 4 (KLF4), known to govern progenitor proliferation and PC fate choice, and PGC1α, which we show controls PC maturation after their specification. PC-specific deletion of AMPKα or PGC1α causes defective PC maturation, which could not be rescued by metformin. However, metformin treatment still increases KLF4 levels and suppresses progenitor proliferation. Thus, AMPK activates KLF4 in progenitors to reduce self-renewal and promote PC fate, whereas AMPK-PGC1α activation within the PC lineage promotes maturation, providing a potential suggestion for why metformin increases acid secretion and reduces gastric cancer risk in humans.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Miao ZF,Adkins-Threats M,Burclaff JR,Osaki LH,Sun JX,Kefalov Y,He Z,Wang ZN,Mills JCdoi
10.1016/j.stem.2020.03.006subject
Has Abstractpub_date
2020-06-04 00:00:00pages
910-925.e6issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(20)30098-9journal_volume
26pub_type
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