Abstract：
VIDEO ABSTRACT:Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical PKC-CBP pathway is essential for the normal genesis of neurons from neural precursors and that metformin activates this pathway to promote rodent and human neurogenesis in culture. Metformin also enhances neurogenesis in the adult mouse brain in a CBP-dependent fashion, and in so doing enhances spatial reversal learning in the water maze. Thus, metformin, by activating an aPKC-CBP pathway, recruits neural stem cells and enhances neural function, thereby providing a candidate pharmacological approach for nervous system therapy.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Wang J,Gallagher D,DeVito LM,Cancino GI,Tsui D,He L,Keller GM,Frankland PW,Kaplan DR,Miller FDdoi
10.1016/j.stem.2012.03.016subject
Has Abstractpub_date
2012-07-06 00:00:00pages
23-35issue
1eissn
1934-5909issn
1875-9777pii
S1934-5909(12)00174-9journal_volume
11pub_type
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