Abstract：
:While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives pancreas and liver.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Kaestner KHdoi
10.1016/j.stem.2015.03.006subject
Has Abstractpub_date
2015-04-02 00:00:00pages
343-4issue
4eissn
1934-5909issn
1875-9777pii
S1934-5909(15)00117-4journal_volume
16pub_type
评论,杂志文章相关文献
Cell Stem Cell文献大全abstract：:Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaer...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2011.09.010
更新日期：2011-10-04 00:00:00
abstract：:Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of photoreceptors in age-related macular degeneration and subtypes of retinitis pigmentosa. Human embryonic stem cells (hESCs) may serve as an unlimited source of RPE cells for transplantation in these blinding conditions. Here we show the ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2009.07.002
更新日期：2009-10-02 00:00:00
abstract：:The mouse placenta was unveiled as an important reservoir for hematopoietic stem cells (HSCs), yet the origin of placental HSCs was unknown. By tracking developing HSCs by expression of Runx1-lacZ and CD41, we have found that HSCs emerge in large vessels in the placenta. Analysis of Ncx1(-/-) embryos, which lack a hea...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2008.01.001
更新日期：2008-03-06 00:00:00
abstract：:Hematopoiesis is a complex process that requires a high degree of transcriptional diversification during lineage commitment and differentiation. de Graaf et al. (2016) have now generated a comprehensive gene expression dataset that allows cell-type-specific genes as well as associated transcription factor expression p...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2016.07.010
更新日期：2016-08-04 00:00:00
abstract：:Although the clinical outcomes of cell therapy trials have not met initial expectations, emerging evidence suggests that injury-mediated tissue damage might benefit from the delivery of cells or their secreted products. Pluripotent stem cells (PSCs) are promising cell sources primarily because of their capacity to gen...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2019.10.001
更新日期：2019-11-07 00:00:00
abstract：:In this issue of Cell Stem Cell, Palii et al. reveal that TAL1 is a master regulator of adhesion and migration networks in human endothelial progenitors and that ex vivo treatment with the histone deacetylase inhibitor TSA enables their faster vascularization after ischemic injury. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.04.018
更新日期：2014-05-01 00:00:00
abstract：:In this issue of Cell Stem Cell, Saito et al. (2015) examine how leukemia-initiating cells react to metabolic stress imposed by different tissue environments. They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged glucose metabolism and redox homeostasis, resulting...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2015.10.007
更新日期：2015-11-05 00:00:00
abstract：:Centralized banking of human embryonic stem (hES) cells is an endeavor that can benefit individual research efforts and enhance international collaboration but is complicated by the fact that the science is rapidly evolving in an environment of heterogeneous laws, guidelines, and ethical standards. Written from the va...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2008.03.018
更新日期：2008-04-10 00:00:00
abstract：:Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the fish retina and foll...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2011.11.004
更新日期：2011-12-02 00:00:00
abstract：:In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2014.06.001
更新日期：2014-08-07 00:00:00
abstract：:A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at th...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2009.06.016
更新日期：2009-07-02 00:00:00
abstract：:The Notch signaling pathway is activated in the majority of T cell acute lymphoblastic leukemias (T-ALL). Adding to the complexity of Notch signaling in hematopoiesis, recently in Nature, Klinakis et al. (2011) demonstrate a tumor-suppressor function for the Notch pathway in myeloid malignancy. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2011.04.010
更新日期：2011-06-03 00:00:00
abstract：:Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2009.10.003
更新日期：2009-12-04 00:00:00
abstract：:The California Institute for Regenerative Medicine (CIRM) Alpha Stem Cell Clinic (ASCC) Network was launched in 2015 to address a compelling unmet medical need for rigorous, FDA-regulated, stem cell-related clinical trials for patients with challenging, incurable diseases. Here, we describe our multi-center experience...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.05.007
更新日期：2018-06-01 00:00:00
abstract：:The emerging field of regenerative rehabilitation integrates biological and bioengineering advances in regenerative medicine with rehabilitative sciences. Here we highlight recent stem cell-based examples of the regenerative rehabilitation paradigm to promote tissue repair and regeneration, and we discuss remaining ch...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2018.02.003
更新日期：2018-03-01 00:00:00
abstract：:Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determina...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2015.06.011
更新日期：2015-07-02 00:00:00
abstract：:In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 genes. We were able to predict causal variants for these expression quantitative trait loci (e...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2017.03.009
更新日期：2017-04-06 00:00:00
abstract：:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2012.05.012
更新日期：2012-06-14 00:00:00
abstract：:Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling coordinated genome-wide activation of species- and context-specific gene expression programs, but such regulation must be balanced against th...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2019.03.012
更新日期：2019-05-02 00:00:00
abstract：:Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unkn...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.01.017
更新日期：2015-03-05 00:00:00
abstract：:Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved. Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions. Like cells of the blastocyst, the resulting naive ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.10.006
更新日期：2017-01-05 00:00:00
abstract：:Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcript...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2019.09.007
更新日期：2019-10-03 00:00:00
abstract：:Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique subtypes are urgently needed for precision medicine development. Here, we have established a primary gastric cancer organoid (GCO) biobank that comprises norma...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.09.016
更新日期：2018-12-06 00:00:00
abstract：:Two recent papers outline improvements in gene editing technology that may facilitate the analysis of signaling networks important for development. The systems developed by both Thyagarajan and coworkers (Thyagarajan et al., 2007) in Nature Biotechnology, and Lombardo and colleagues (Lombardo et al., 2007) in Stem Cel...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2007.11.004
更新日期：2007-12-13 00:00:00
abstract：:In this issue of Cell Stem Cell, Pei et al. (2018) demonstrate that leukemic stem cells (LSCs) have enhanced mitochondrial fission, which is positively regulated by FIS1. FIS1 is necessary to maintain LSC function; thus, targeting its expression and mitochondrial fission is a novel approach to decrease stemness and in...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.05.026
更新日期：2018-07-05 00:00:00
abstract：:The 2010 Annual Meeting of the International Society for Stem Cell Research (ISSCR) was held in San Francisco in June with an exciting program covering a wealth of stem cell research from basic science to clinical research. ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.09.002
更新日期：2010-10-08 00:00:00
abstract：:Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2017.09.014
更新日期：2017-11-02 00:00:00
abstract：:We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by a single neural transcription factor, NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrate that sequentia...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.09.012
更新日期：2015-12-03 00:00:00
abstract：:Innate immune factors may restrict hematopoietic stem cell (HSC) genetic engineering and contribute to broad individual variability in gene therapy outcomes. Here, we show that HSCs harbor an early, constitutively active innate immune block to lentiviral transduction that can be efficiently overcome by cyclosporine H ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.10.008
更新日期：2018-12-06 00:00:00
abstract：:Chimeras are individuals with tissues derived from more than one zygote. Interspecific chimeras have tissues derived from different species. The biological consequences of human-animal chimeras have become an issue of ethical debate. Ironically, human-animal chimeras with human blood, neurons, germ cells, and other ti...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2007.07.021
更新日期：2007-09-13 00:00:00
