Abstract:
:Chimeras are individuals with tissues derived from more than one zygote. Interspecific chimeras have tissues derived from different species. The biological consequences of human-animal chimeras have become an issue of ethical debate. Ironically, human-animal chimeras with human blood, neurons, germ cells, and other tissues have been generated for decades. This has facilitated human biological studies and therapeutic strategies for disease.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Behringer RRdoi
10.1016/j.stem.2007.07.021subject
Has Abstractpub_date
2007-09-13 00:00:00pages
259-62issue
3eissn
1934-5909issn
1875-9777pii
S1934-5909(07)00087-2journal_volume
1pub_type
杂志文章,评审相关文献
Cell Stem Cell文献大全abstract::Exit from the naive pluripotent state occurs through a series of changes in the gene regulatory circuitry, allowing cells to become primed for lineage commitment. In this issue of Cell Stem Cell, Kalkan et al. (2019) show that three transcription regulators are required for naive mouse embryonic stem cells (ESCs) to e...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2019.04.008
更新日期:2019-05-02 00:00:00
abstract::Neuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neurons or skeletal muscles in monolayer culture. Here, we use hPSC-deriv...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.12.007
更新日期:2020-02-06 00:00:00
abstract::The identification of mechanisms that regulate stem cell renewal has led to the development of innovative approaches to expand hematopoietic stem cells ex vivo. One approach reported by Wagner et al. (2016) in this issue of Cell Stem Cell has demonstrated dramatic expansion of umbilical cord blood stem cells that prom...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.12.011
更新日期:2016-01-07 00:00:00
abstract::The maintenance of a pool of quiescent satellite cells (muscle stem cells) is necessary for long-term muscle health. In this issue of Cell Stem Cell, Verma et al. (2018) show that satellite cells recruit endothelial cells to create a vascular niche and that cross-talk between endothelial and satellite cells is vital f...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2018.09.013
更新日期:2018-10-04 00:00:00
abstract::In a pioneering study in New England Journal of Medicine, Schweitzer et al. (2020) report on a patient with Parkinson's disease who received a graft of dopamine neurons obtained from in vitro differentiated induced pluripotent stem cells, derived from the patient's own skin fibroblasts, showing the feasibility of auto...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.06.008
更新日期:2020-07-02 00:00:00
abstract::The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to promote regeneration of damaged tissue, to treat inflammation, and to promote angiogenesis. However, these studies are complicated by the diverse methods used to culture, characterize, and deliver MSCs and by the variety of meth...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2009.02.001
更新日期:2009-03-06 00:00:00
abstract::In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogen...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.11.013
更新日期:2019-01-03 00:00:00
abstract::Combination of stem cell-based approaches with gene-editing technologies represents an attractive strategy for studying human disease and developing therapies. However, gene-editing methodologies described to date for human cells suffer from technical limitations including limited target gene size, low targeting effic...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.04.019
更新日期:2011-06-03 00:00:00
abstract::Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by reprogramming their nuclei to a totipotent state. However, successful full-term development of SCNT embryos is a low-efficiency process and arrested embryos frequently exhibit epigenetic abnormalities. Here, we generated genome-wide DNA me...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.07.017
更新日期:2018-09-06 00:00:00
abstract::Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in huma...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.03.002
更新日期:2016-05-05 00:00:00
abstract::Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2015.08.005
更新日期:2015-11-05 00:00:00
abstract::A recent publication in Nature by Conrad et al. (2008) reports the generation of pluripotent stem cells from isolated human adult testicular germ cells. This work identifies a new source of stem cells for potential autologous therapeutic applications in men. ...
journal_title:Cell stem cell
pub_type:
doi:10.1016/j.stem.2008.10.009
更新日期:2008-11-06 00:00:00
abstract::Heterogeneity within the self-renewal durability of adult hematopoietic stem cells (HSCs) challenges our understanding of the molecular framework underlying HSC function. Gene expression studies have been hampered by the presence of multiple HSC subtypes and contaminating non-HSCs in bulk HSC populations. To gain deep...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2015.04.004
更新日期:2015-06-04 00:00:00
abstract::Secreted frizzled-related protein 1 (Sfrp1) is highly expressed by stromal cells maintaining hematopoietic stem cells (HSCs). Sfrp1 loss in stromal cells increases production of hematopoietic progenitors, and in knockout mice, dysregulates hemostasis and increases Flk2- Cd34- Lin- Sca1+ Kit+ (LSK) cell numbers in bone...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.05.020
更新日期:2009-08-07 00:00:00
abstract::Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonica...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2013.01.014
更新日期:2013-02-07 00:00:00
abstract::Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.10.003
更新日期:2009-12-04 00:00:00
abstract::Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed a proof-of-concept for hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide th...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.08.004
更新日期:2019-10-03 00:00:00
abstract::Structural and transcriptional changes during early brain maturation follow fixed developmental programs defined by genetics. However, whether this is true for functional network activity remains unknown, primarily due to experimental inaccessibility of the initial stages of the living human brain. Here, we developed ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.08.002
更新日期:2019-10-03 00:00:00
abstract::Adipose stromal cells (ASCs) serve as mesenchymal progenitors in white adipose tissue (WAT). Intercellular interactions involving ASCs have remained obscure. By merging phage display technology with fluorescence-activated cell sorting (FACS), we screened a combinatorial library for peptides that target mouse ASCs in v...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.05.017
更新日期:2011-07-08 00:00:00
abstract::Two recent papers outline improvements in gene editing technology that may facilitate the analysis of signaling networks important for development. The systems developed by both Thyagarajan and coworkers (Thyagarajan et al., 2007) in Nature Biotechnology, and Lombardo and colleagues (Lombardo et al., 2007) in Stem Cel...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2007.11.004
更新日期:2007-12-13 00:00:00
abstract::Hematopoietic stem cells (HSCs) sustain hematopoiesis throughout life. HSCs exit dormancy to restore hemostasis in response to stressful events, such as acute blood loss, and must return to a quiescent state to prevent their exhaustion and resulting bone marrow failure. HSC activation is driven in part through the pho...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.05.003
更新日期:2018-06-01 00:00:00
abstract::Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages o...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.01.004
更新日期:2012-02-03 00:00:00
abstract::Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cy...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.05.007
更新日期:2014-06-05 00:00:00
abstract::Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not recapitulate critical myelination phenotypes and it is therefore not c...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.07.009
更新日期:2018-08-02 00:00:00
abstract::Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing (RNA-seq). The transcriptomes of multiple cycling ISC populations clo...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2017.06.014
更新日期:2017-07-06 00:00:00
abstract::Cell cycle regulators play critical roles in the balance between hematopoietic stem cell (HSC) dormancy and proliferation. In this study, we report that cell cycle entry proceeded normally in HSCs null for cyclin-dependent kinase (CDK) inhibitor p57 due to compensatory upregulation of p27. HSCs null for both p57 and p...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.07.003
更新日期:2011-09-02 00:00:00
abstract::SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental pl...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.06.015
更新日期:2020-07-02 00:00:00
abstract::Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2014.11.009
更新日期:2014-12-04 00:00:00
abstract::Ezh2, the methyltransferase within Polycomb Repressive II Complexes, was thought to be essential for all H3K27me3 marks in embryonic stem cells (ESCs). Recently in Molecular Cell, Shen and colleagues (2008) revealed that EZH2 is dispensable for ESC derivation and self-renewal, and that EZH1 may unexpectedly compensate...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2008.11.007
更新日期:2008-12-04 00:00:00
abstract::Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.09.008
更新日期:2015-10-01 00:00:00