Abstract:
:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), with signaling pathways that control the behavior of NSCs. NSCs in the adult brain stretch into physiologically distinct compartments of their niche. We propose how adult NSCs' morphology may allow these cells to integrate multiple signaling pathways arising from unique locations of their niche.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Fuentealba LC,Obernier K,Alvarez-Buylla Adoi
10.1016/j.stem.2012.05.012subject
Has Abstractpub_date
2012-06-14 00:00:00pages
698-708issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(12)00245-7journal_volume
10pub_type
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