Adult neural stem cells bridge their niche.

Abstract:

:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), with signaling pathways that control the behavior of NSCs. NSCs in the adult brain stretch into physiologically distinct compartments of their niche. We propose how adult NSCs' morphology may allow these cells to integrate multiple signaling pathways arising from unique locations of their niche.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Fuentealba LC,Obernier K,Alvarez-Buylla A

doi

10.1016/j.stem.2012.05.012

subject

Has Abstract

pub_date

2012-06-14 00:00:00

pages

698-708

issue

6

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(12)00245-7

journal_volume

10

pub_type

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