Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

abstract：:Bmi1 is required for efficient self-renewal of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). In this study, we investigated whether leukemia-associated fusion proteins, which differ in their ability to activate Hox expression, could initiate leukemia in the absence of Bmi1. AML1-ETO and PLZF-RARα, wh...

journal_title：Cell stem cell

authors： Smith LL,Yeung J,Zeisig BB,Popov N,Huijbers I,Barnes J,Wilson AJ,Taskesen E,Delwel R,Gil J,Van Lohuizen M,So CW

更新日期：2011-06-03 00:00:00

abstract：:Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...

journal_title：Cell stem cell

authors： Barker RA,Parmar M,Studer L,Takahashi J

更新日期：2017-11-02 00:00:00

abstract：:Embryonic stem cells (ESCs) are an attractive source for tissue regeneration and repair therapies because they can be differentiated into virtually any cell type in the adult body. However, for this approach to succeed, the transplanted ESCs must survive long enough to generate a therapeutic benefit. A major obstacle ...

journal_title：Cell stem cell

authors： Pearl JI,Lee AS,Leveson-Gower DB,Sun N,Ghosh Z,Lan F,Ransohoff J,Negrin RS,Davis MM,Wu JC

更新日期：2011-03-04 00:00:00

abstract：:Innate immune factors may restrict hematopoietic stem cell (HSC) genetic engineering and contribute to broad individual variability in gene therapy outcomes. Here, we show that HSCs harbor an early, constitutively active innate immune block to lentiviral transduction that can be efficiently overcome by cyclosporine H ...

journal_title：Cell stem cell

authors： Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

更新日期：2018-12-06 00:00:00

abstract：:In this issue of Cell Stem Cell, Feng et al. (2013) report that the gene mutated in human CHARGE syndrome, ATP-dependent chromatin remodeling factor CHD7, contributes to the control of neurogenesis. The authors also report that exercise ameliorates these defects and suggest it as an intervention worthy of study in CHA...

journal_title：Cell stem cell

authors： Kim KH,Roberts CW

更新日期：2013-07-03 00:00:00

abstract：:In injured tissues, regeneration is often associated with cell fate plasticity, in that cells deviate from their normal lineage paths. It is becoming increasingly clear that this plasticity often creates alternative strategies to restore damaged or lost cells. Alternatively, cell fate plasticity is also part and parce...

journal_title：Cell stem cell

authors： Lin B,Srikanth P,Castle AC,Nigwekar S,Malhotra R,Galloway JL,Sykes DB,Rajagopal J

更新日期：2018-09-06 00:00:00

abstract：:DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet...

journal_title：Cell stem cell

authors： Zhang RR,Cui QY,Murai K,Lim YC,Smith ZD,Jin S,Ye P,Rosa L,Lee YK,Wu HP,Liu W,Xu ZM,Yang L,Ding YQ,Tang F,Meissner A,Ding C,Shi Y,Xu GL

更新日期：2013-08-01 00:00:00

abstract：:The 2009 ISSCR Annual Meeting in Barcelona will draw stem cell scientists from around the world to Europe, to connect to each other and to the local community. With record abstract submissions, we are sure to have an exciting meeting. ...

journal_title：Cell stem cell

authors： McKay RD

更新日期：2009-06-05 00:00:00

abstract：:With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during preimplantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demethylation, but demethy...

journal_title：Cell stem cell

authors： Shen L,Inoue A,He J,Liu Y,Lu F,Zhang Y

更新日期：2014-10-02 00:00:00

abstract：:In the mouse embryo, the aorta-gonad-mesonephros (AGM) region is considered to be the sole location for intraembryonic emergence of hematopoietic stem cells (HSCs). Here we report that, in parallel to the AGM region, the E10.5-E11.5 mouse head harbors bona fide HSCs, as defined by long-term, high-level, multilineage r...

journal_title：Cell stem cell

authors： Li Z,Lan Y,He W,Chen D,Wang J,Zhou F,Wang Y,Sun H,Chen X,Xu C,Li S,Pang Y,Zhang G,Yang L,Zhu L,Fan M,Shang A,Ju Z,Luo L,Ding Y,Guo W,Yuan W,Yang X,Liu B

更新日期：2012-11-02 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, we comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. We utilize complementary genome-wide techniques includin...

journal_title：Cell stem cell

authors： Ramos AD,Diaz A,Nellore A,Delgado RN,Park KY,Gonzales-Roybal G,Oldham MC,Song JS,Lim DA

更新日期：2013-05-02 00:00:00

abstract：:The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-trac...

journal_title：Cell stem cell

authors： Beaudin AE,Boyer SW,Perez-Cunningham J,Hernandez GE,Derderian SC,Jujjavarapu C,Aaserude E,MacKenzie T,Forsberg EC

更新日期：2016-12-01 00:00:00

abstract：:The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to promote regeneration of damaged tissue, to treat inflammation, and to promote angiogenesis. However, these studies are complicated by the diverse methods used to culture, characterize, and deliver MSCs and by the variety of meth...

journal_title：Cell stem cell

authors： Karp JM,Leng Teo GS

更新日期：2009-03-06 00:00:00

abstract：:The identification of tumor-initiating cells represents a significant challenge for studies of prostate cancer. In a recent issue of Cell Reports, Agarwal and colleagues use organoid culture to ascertain two distinct luminal progenitors in a mouse model of prostate cancer, shedding new light on lineage relationships i...

journal_title：Cell stem cell

authors： Shen MM

更新日期：2015-12-03 00:00:00

abstract：:Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determina...

journal_title：Cell stem cell

authors： Wang C,Fong H,Huang Y

更新日期：2015-07-02 00:00:00

abstract：:Cells of adult mammals can be converted (reprogrammed) to new cells. In one approach, adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate new cell types. Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these ...

journal_title：Cell stem cell

authors： Zhou Q,Melton DA

更新日期：2008-10-09 00:00:00

abstract：:The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes. Despite recent publications of DNA sequence variations in the iPSCs, the true scope of such changes for the entire genome is not clear. Here we report the whole-g...

journal_title：Cell stem cell

authors： Cheng L,Hansen NF,Zhao L,Du Y,Zou C,Donovan FX,Chou BK,Zhou G,Li S,Dowey SN,Ye Z,NISC Comparative Sequencing Program.,Chandrasekharappa SC,Yang H,Mullikin JC,Liu PP

更新日期：2012-03-02 00:00:00

abstract：:Neurons derived from human pluripotent stem cells (hPSCs) are powerful tools for studying human neural development and diseases. Robust functional coupling of hPSC-derived neurons with target tissues in vitro is essential for modeling intercellular physiology in a dish and to further translational studies, but it has ...

journal_title：Cell stem cell

authors： Oh Y,Cho GS,Li Z,Hong I,Zhu R,Kim MJ,Kim YJ,Tampakakis E,Tung L,Huganir R,Dong X,Kwon C,Lee G

更新日期：2016-07-07 00:00:00

abstract：:Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor...

journal_title：Cell stem cell

authors： Goldman O,Han S,Sourisseau M,Dziedzic N,Hamou W,Corneo B,D'Souza S,Sato T,Kotton DN,Bissig KD,Kalir T,Jacobs A,Evans T,Evans MJ,Gouon-Evans V

更新日期：2013-06-06 00:00:00

abstract：:Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...

journal_title：Cell stem cell

authors： Kubaczka C,Senner CE,Cierlitza M,Araúzo-Bravo MJ,Kuckenberg P,Peitz M,Hemberger M,Schorle H

更新日期：2015-11-05 00:00:00

abstract：:Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved. Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions. Like cells of the blastocyst, the resulting naive ...

journal_title：Cell stem cell

authors： Sahakyan A,Kim R,Chronis C,Sabri S,Bonora G,Theunissen TW,Kuoy E,Langerman J,Clark AT,Jaenisch R,Plath K

更新日期：2017-01-05 00:00:00

abstract：:Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy m...

journal_title：Cell stem cell

authors： MacKenzie TC

更新日期：2018-09-06 00:00:00

abstract：:Pluripotent stem cells are defined by their capacity to differentiate into all three tissue layers that comprise the body. Chimera formation, generated by stem cell transplantation to the embryo, is a stringent assessment of stem cell pluripotency. However, the ability of human pluripotent stem cells (hPSCs) to form e...

journal_title：Cell stem cell

authors： Mascetti VL,Pedersen RA

更新日期：2016-01-07 00:00:00

abstract：:A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at th...

journal_title：Cell stem cell

authors： Guilak F,Cohen DM,Estes BT,Gimble JM,Liedtke W,Chen CS

更新日期：2009-07-02 00:00:00

abstract：:Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...

journal_title：Cell stem cell

authors： Sun B,Halabisky B,Zhou Y,Palop JJ,Yu G,Mucke L,Gan L

更新日期：2009-12-04 00:00:00

abstract：:The nature of compensation for women who donate eggs (oocytes) for research remains a contentious issue internationally. This position paper lays out the arguments for, and discusses the arrangements in which, a modest payment might be ethically justifiable. ...

journal_title：Cell stem cell

authors： Haimes E,Skene L,Ballantyne AJ,Caulfield T,Goldstein LS,Hyun I,Kimmelman J,Robert JS,Roxland BE,Scott CT,Solbakk JH,Sugarman J,Taylor PL,Testa G,ISSCR.

更新日期：2013-03-07 00:00:00

abstract：:Precise lineage trajectories and the cellular sources that contribute to regeneration after injury are largely unknown in many tissues. In this issue of Cell Stem Cell, Gadye et al. (2017) and Lin et al. (2017) show that olfactory epithelial cells transit through unique and unfamiliar paths of differentiation and unde...

journal_title：Cell stem cell

authors： Konkimalla A,Tata PR

更新日期：2017-12-07 00:00:00

abstract：:Reconstructing lineage relationships between cells within a tissue or organism is a long-standing aim in biology. Traditionally, lineage tracing has been achieved through the (genetic) labeling of a cell followed by the tracking of its offspring. Currently, lineage trajectories can also be predicted using single-cell ...

journal_title：Cell stem cell

authors： Kester L,van Oudenaarden A

更新日期：2018-08-02 00:00:00

abstract：:In this issue of Cell Stem Cell, Shook et al. (2020) reveal that dermal adipocytes regulate skin wound repair via release of fatty acids that promote macrophage recruitment and accelerated revascularization. Furthermore, mature dermal adipocytes dedifferentiate into migratory extracellularmatrix-producing myofibroblas...

journal_title：Cell stem cell

authors： Merrick D,Seale P

更新日期：2020-06-04 00:00:00

abstract：:COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell investigators impacted by the closures. Here, they introduce themselves and thei...

journal_title：Cell stem cell

authors：

更新日期：2020-07-02 00:00:00