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Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells.

Abstract：

:Embryonic stem cells (ESCs) are an attractive source for tissue regeneration and repair therapies because they can be differentiated into virtually any cell type in the adult body. However, for this approach to succeed, the transplanted ESCs must survive long enough to generate a therapeutic benefit. A major obstacle facing the engraftment of ESCs is transplant rejection by the immune system. Here we show that blocking leukocyte costimulatory molecules permits ESC engraftment. We demonstrate the success of this immunosuppressive therapy for mouse ESCs, human ESCs, mouse induced pluripotent stem cells (iPSCs), human induced pluripotent stem cells, and more differentiated ESC/(iPSCs) derivatives. Additionally, we provide evidence describing the mechanism by which inhibition of costimulatory molecules suppresses T cell activation. This report describes a short-term immunosuppressive approach capable of inducing engraftment of transplanted ESCs and iPSCs, providing a significant improvement in our mechanistic understanding of the critical role costimulatory molecules play in leukocyte activation.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Pearl JI,Lee AS,Leveson-Gower DB,Sun N,Ghosh Z,Lan F,Ransohoff J,Negrin RS,Davis MM,Wu JC

doi

10.1016/j.stem.2011.01.012

subject

Has Abstract

pub_date

2011-03-04 00:00:00

pages

309-17

issue

3

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(11)00013-0

journal_volume

8

pub_type

杂志文章

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