Abstract：
:Cell-autonomous Wnt signaling has well-characterized functions in controlling stem cell activity, including in the prostate. While niche cells secrete Wnt ligands, the effects of Wnt signaling in niche cells per se are less understood. Here, we show that stromal cells in the proximal prostatic duct near the urethra, a mouse prostate stem cell niche, not only produce multiple Wnt ligands but also exhibit strong Wnt/β-catenin activity. The non-canonical Wnt ligand Wnt5a, secreted by proximal stromal cells, directly inhibits proliefration of prostate epithelial stem or progenitor cells whereas stromal cell-autonomous canonical Wnt/β-catenin signaling indirectly suppresses prostate stem or progenitor activity via the transforming growth factor β (TGFβ) pathway. Collectively, these pathways restrain the proliferative potential of epithelial cells in the proximal prostatic ducts. Human prostate likewise exhibits spatially restricted distribution of stromal Wnt/β-catenin activity, suggesting a conserved mechanism for tissue patterning. Thus, this study shows how distinct stromal signaling mechanisms within the prostate cooperate to regulate tissue homeostasis.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Wei X,Zhang L,Zhou Z,Kwon OJ,Zhang Y,Nguyen H,Dumpit R,True L,Nelson P,Dong B,Xue W,Birchmeier W,Taketo MM,Xu F,Creighton CJ,Ittmann MM,Xin Ldoi
10.1016/j.stem.2019.03.010subject
Has Abstractpub_date
2019-05-02 00:00:00pages
753-768.e6issue
5eissn
1934-5909issn
1875-9777pii
S1934-5909(19)30109-2journal_volume
24pub_type
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