Abstract：
:Polycomb group (PcG) proteins are essential regulators of stem cells. PcG and trithorax group proteins mark developmental regulator gene promoters with bivalent domains consisting of overlapping repressive and activating histone modifications to keep them poised for activation in embryonic stem cells. Bmi1, a component of PcG complexes, maintains the self-renewal capacity of adult stem cells, but its role in multipotency remains obscure. Here we show that Bmi1 is critical for multipotency of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs). B cell lineage developmental regulator genes, Ebf1 and Pax5, appeared to be transcriptionally repressed by bivalent domains before lineage commitment. Loss of Bmi1 resulted in a resolution of bivalent domains at the Ebf1 and Pax5 loci, leading to their premature expression in HSC/MPPs accompanied by accelerated lymphoid specification and a marked reduction in HSC/MPPs. Thus, Bmi1 is required to reinforce bivalent domains at key developmental regulator gene loci to maintain lineage specification poised for activation in adult stem cells.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Oguro H,Yuan J,Ichikawa H,Ikawa T,Yamazaki S,Kawamoto H,Nakauchi H,Iwama Adoi
10.1016/j.stem.2010.01.005subject
Has Abstractpub_date
2010-03-05 00:00:00pages
279-86issue
3eissn
1934-5909issn
1875-9777pii
S1934-5909(10)00006-8journal_volume
6pub_type
杂志文章相关文献
Cell Stem Cell文献大全abstract：:Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2017.02.010
更新日期：2017-03-02 00:00:00
abstract：:Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2009.10.003
更新日期：2009-12-04 00:00:00
abstract：:The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular pathways essential for brain development and autoph...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.07.019
更新日期：2016-11-03 00:00:00
abstract：:The nature of compensation for women who donate eggs (oocytes) for research remains a contentious issue internationally. This position paper lays out the arguments for, and discusses the arrangements in which, a modest payment might be ethically justifiable. ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.02.002
更新日期：2013-03-07 00:00:00
abstract：:Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to a...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2010.12.012
更新日期：2011-01-07 00:00:00
abstract：:Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cy...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.05.007
更新日期：2014-06-05 00:00:00
abstract：:Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.04.026
更新日期：2013-06-06 00:00:00
abstract：:Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.08.005
更新日期：2015-11-05 00:00:00
abstract：:Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here ...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2015.05.002
更新日期：2015-06-04 00:00:00
abstract：:DNA methylation is an epigenetic mark that plays pivotal roles in gene regulation, but its functions in neural fate decisions are poorly understood. In this issue of Cell Stem Cell, Ziller et al. (2018) show that the de novo methyltransferase Dnmt3a ensures efficient generation of motor neurons from stem cells. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.03.006
更新日期：2018-04-05 00:00:00
abstract：:Regulation of hematopoietic stem cell (HSC) dormancy by specific cell types in the hematopoietic niche remains poorly understood. Yamazaki et al. (2011) now report that nerve-associated nonmyelinating Schwann cells activate TGF-β to maintain dormant HSCs, suggesting that glia are novel players in the bone marrow niche...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2011.11.016
更新日期：2011-12-02 00:00:00
abstract：:Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.02.003
更新日期：2014-03-06 00:00:00
abstract：:Inducing immune tolerance to prevent rejection is a key step toward successful engraftment of stem-cell-derived tissue in a clinical setting. Using human pluripotent stem cells to generate thymic epithelial cells (TECs) capable of supporting T cell development represents a promising approach to reach this goal; howeve...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.04.004
更新日期：2013-08-01 00:00:00
abstract：:Recently in Nature Neuroscience, Gaillard et al. (2007) study axonal projections from embryonic cortical explants grafted into acutely damaged adult motor cortex. After attempting to rule out fusion of donor tissue with pre-existing host circuitry, the authors report robust long-distance donor axonal projections and s...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2007.09.012
更新日期：2007-10-11 00:00:00
abstract：:Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2012.05.027
更新日期：2012-09-07 00:00:00
abstract：:The maintenance of a pool of quiescent satellite cells (muscle stem cells) is necessary for long-term muscle health. In this issue of Cell Stem Cell, Verma et al. (2018) show that satellite cells recruit endothelial cells to create a vascular niche and that cross-talk between endothelial and satellite cells is vital f...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.09.013
更新日期：2018-10-04 00:00:00
abstract：:Like politics, most developmental signals are local. However, in this issue of Cell Stem Cell, Kwan et al. (2016) and colleagues describe how a stress-induced signal that originates in the zebrafish brain promotes the formation of blood at a distant site, the dorsal aorta. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2016.08.011
更新日期：2016-09-01 00:00:00
abstract：:New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ul...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.12.003
更新日期：2017-01-05 00:00:00
abstract：:The cellular identity of niche cells that regulate hematopoietic stem cell (HSC) self-renewal and differentiation has been debated for several years. Two recent studies in Nature (Ding and Morrison, 2013; Greenbaum et al., 2013) have shed light into the bone marrow stromal subsets making CXCL12, a chemokine critical f...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2013.03.012
更新日期：2013-04-04 00:00:00
abstract：:Individuals with neurofibromatosis type 1 (NF1) develop abnormalities of both neuronal and glial cell lineages, suggesting that the NF1 protein neurofibromin is an essential regulator of neuroglial progenitor function. In this regard, Nf1-deficient embryonic telencephalic neurospheres exhibit increased self-renewal an...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2007.07.008
更新日期：2007-10-11 00:00:00
abstract：:Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for regenerative medicine. Herein we provide a perspective regarding these developments, compare phenotypes of the insulin-containing cells to human β cells, and discuss impli...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2014.10.012
更新日期：2014-11-06 00:00:00
abstract：:In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-de...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2020.01.022
更新日期：2020-03-05 00:00:00
abstract：:In this issue of Cell Stem Cell, Csaszar et al. (2012) develop a culture method that overcomes current limitations in ex vivo hematopoietic stem/progenitor cell expansion by continuously diluting inhibitory signaling factors and maintaining stem cell density. This approach enhances the generation of precursors with po...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2012.01.012
更新日期：2012-02-03 00:00:00
abstract：:The lineage restriction of prospectively isolated hematopoietic progenitors has been traditionally assessed by bulk in vitro culture and transplantation of large number of cells in vivo. These methods, however, cannot distinguish between homogenous multipotent or heterogeneous lineage-restricted populations. Using clo...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.02.013
更新日期：2010-04-02 00:00:00
abstract：:Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.06.006
更新日期：2015-08-06 00:00:00
abstract：:The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways. While Gsk3 inhibition has been attribut...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2014.04.015
更新日期：2014-06-05 00:00:00
abstract：:The study of gastric epithelial homeostasis and cancer has been hampered by the lack of stem cell markers and in vitro culture methods. The Wnt target gene Lgr5 marks stem cells in the small intestine, colon, and hair follicle. Here, we investigated Lgr5 expression in the stomach and assessed the stem cell potential o...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2009.11.013
更新日期：2010-01-08 00:00:00
abstract：:The California Institute for Regenerative Medicine (CIRM) Alpha Stem Cell Clinic (ASCC) Network was launched in 2015 to address a compelling unmet medical need for rigorous, FDA-regulated, stem cell-related clinical trials for patients with challenging, incurable diseases. Here, we describe our multi-center experience...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.05.007
更新日期：2018-06-01 00:00:00
abstract：VIDEO ABSTRACT:Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2012.03.016
更新日期：2012-07-06 00:00:00
abstract：:During embryonic development, multipotent cardiovascular progenitor cells are specified from early mesoderm. Using mouse ESCs in which gene expression can be temporally regulated, we have found that transient expression of Mesp1 dramatically accelerates and enhances multipotent cardiovascular progenitor specification ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2008.06.009
更新日期：2008-07-03 00:00:00
