当前位置： SCI文献检索 > Cell Stem Cell期刊下所有文献 > Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells.

Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells.

Abstract：

:Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to viral integration. Here, we review recent progress made in the usage of genetic factors, chemical inhibitors, and signaling molecules that can either replace core reprogramming factors or enhance reprogramming efficiency. Current iPSC studies will provide a paradigm for the combinatorial use of genetic factors and chemicals for the broader applications to alter cellular states of potency.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Feng B,Ng JH,Heng JC,Ng HH

doi

10.1016/j.stem.2009.03.005

subject

Has Abstract

pub_date

2009-04-03 00:00:00

pages

301-12

issue

4

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(09)00106-4

journal_volume

4

pub_type

杂志文章,评审

相关文献

Cell Stem Cell文献大全
  • Venetolax with Azacitidine Drains Fuel from AML Stem Cells.

    abstract：:In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cyc...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2018.12.005

    authors： Nakada D

    更新日期：2019-01-03 00:00:00

  • Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs.

    abstract：:Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets d...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2015.04.009

    authors： Bogdanović O,Lister R

    更新日期：2015-05-07 00:00:00

  • An EZ mark to miss.

    abstract：:Ezh2, the methyltransferase within Polycomb Repressive II Complexes, was thought to be essential for all H3K27me3 marks in embryonic stem cells (ESCs). Recently in Molecular Cell, Shen and colleagues (2008) revealed that EZH2 is dispensable for ESC derivation and self-renewal, and that EZH1 may unexpectedly compensate...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2008.11.007

    authors： Ho L,Crabtree GR

    更新日期：2008-12-04 00:00:00

  • Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?

    abstract：:Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2017.02.010

    authors： Richard-Carpentier G,Sauvageau G

    更新日期：2017-03-02 00:00:00

  • Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.

    abstract：:Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has proven difficult. Here, we took a multifaceted approach to investigate why 15q11.2 copy number variants are prominent risk factors for schizophrenia and autism. Fir...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.05.003

    authors： Yoon KJ,Nguyen HN,Ursini G,Zhang F,Kim NS,Wen Z,Makri G,Nauen D,Shin JH,Park Y,Chung R,Pekle E,Zhang C,Towe M,Hussaini SM,Lee Y,Rujescu D,St Clair D,Kleinman JE,Hyde TM,Krauss G,Christian KM,Rapoport JL,Wein

    更新日期：2014-07-03 00:00:00

  • Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.

    abstract：:Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2017.09.014

    authors： Barker RA,Parmar M,Studer L,Takahashi J

    更新日期：2017-11-02 00:00:00

  • Stem cells to insulin secreting cells: two steps forward and now a time to pause?

    abstract：:Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for regenerative medicine. Herein we provide a perspective regarding these developments, compare phenotypes of the insulin-containing cells to human β cells, and discuss impli...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.10.012

    authors： Kushner JA,MacDonald PE,Atkinson MA

    更新日期：2014-11-06 00:00:00

  • Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells.

    abstract：:Embryonic stem cells (ESCs) are an attractive source for tissue regeneration and repair therapies because they can be differentiated into virtually any cell type in the adult body. However, for this approach to succeed, the transplanted ESCs must survive long enough to generate a therapeutic benefit. A major obstacle ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2011.01.012

    authors： Pearl JI,Lee AS,Leveson-Gower DB,Sun N,Ghosh Z,Lan F,Ransohoff J,Negrin RS,Davis MM,Wu JC

    更新日期：2011-03-04 00:00:00

  • Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.

    abstract：:Recurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromosome separation and DNA damage repair, cohesin complex functions during hemato...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2015.09.017

    authors： Mazumdar C,Shen Y,Xavy S,Zhao F,Reinisch A,Li R,Corces MR,Flynn RA,Buenrostro JD,Chan SM,Thomas D,Koenig JL,Hong WJ,Chang HY,Majeti R

    更新日期：2015-12-03 00:00:00

  • More than One Way to Skin a Wound.

    abstract：:Large cutaneous and non-healing ulcers exhibit impaired epithelialization, which represents a major therapeutic challenge. Recently in Nature, Kurita et al. (2018) reported a surprising potential source of epithelial cells. The authors demonstrate that wound-resident mesenchymal cells can be reprogrammed to generate e...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2018.10.014

    authors： Ankawa R,Fuchs Y

    更新日期：2018-11-01 00:00:00

  • Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

    abstract：:Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding sequences. To investi...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2017.07.008

    authors： Forrest MP,Zhang H,Moy W,McGowan H,Leites C,Dionisio LE,Xu Z,Shi J,Sanders AR,Greenleaf WJ,Cowan CA,Pang ZP,Gejman PV,Penzes P,Duan J

    更新日期：2017-09-07 00:00:00

  • Future AAVenues for In Utero Gene Therapy.

    abstract：:Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy m...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2018.08.010

    authors： MacKenzie TC

    更新日期：2018-09-06 00:00:00

  • Pluripotency network in embryonic stem cells: maybe Leibniz was right all along.

    abstract：:The transcription factors Tcf3 and Nanog regulate many genes in embryonic stem cells, but according to two reports in this issue of Cell Stem Cell (Festuccia et al., 2012, Martello et al., 2012), only one, Esrrb, encoding an orphan nuclear hormone receptor, truly matters in the maintenance of self-renewal. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2012.09.005

    authors： Zwaka TP

    更新日期：2012-10-05 00:00:00

  • RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

    abstract：:N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be frequently deleted, implying a ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2020.04.009

    authors： Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

    更新日期：2020-07-02 00:00:00

  • Kit regulates HSC engraftment across the human-mouse species barrier.

    abstract：:In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.06.001

    authors： Cosgun KN,Rahmig S,Mende N,Reinke S,Hauber I,Schäfer C,Petzold A,Weisbach H,Heidkamp G,Purbojo A,Cesnjevar R,Platz A,Bornhäuser M,Schmitz M,Dudziak D,Hauber J,Kirberg J,Waskow C

    更新日期：2014-08-07 00:00:00

  • Erosion of dosage compensation impacts human iPSC disease modeling.

    abstract：:Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage female hiPSCs retain the inactive X chromosome of the somatic cell they are...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2012.02.014

    authors： Mekhoubad S,Bock C,de Boer AS,Kiskinis E,Meissner A,Eggan K

    更新日期：2012-05-04 00:00:00

  • Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

    abstract：:Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescen...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.12.011

    authors： Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA

    更新日期：2020-03-05 00:00:00

  • Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

    abstract：:Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various therapeutic and research applications. However, several problems remain for t...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2008.10.004

    authors： Shi Y,Desponts C,Do JT,Hahm HS,Schöler HR,Ding S

    更新日期：2008-11-06 00:00:00

  • EPO and super-EPO: erythropoietins direct neoangiogenesis by cardiac progenitor cells.

    abstract：:Erythropoietin, the red blood cell-making cytokine, is also a potential cytoprotective agent in heart disease. In this issue of Cell Stem Cell, Hoch et al. (2011) use two heart failure models, including chemotherapeutic cardiotoxicity, to reveal a mechanistic connection between reduced cardiomyocyte production of eryt...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2011.07.008

    authors： Schneider MD

    更新日期：2011-08-05 00:00:00

  • The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila.

    abstract：:Steroid hormones are known systemic regulators of multiple normal and cancerous tissues; however, whether or how they impact the fate and function of adult stem cells is unclear. In the Drosophila ovary, insulin signals modulate the proliferation and self-renewal of germline stem cells (GSCs), yet despite evidence tha...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2010.10.001

    authors： Ables ET,Drummond-Barbosa D

    更新日期：2010-11-05 00:00:00

  • A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.

    abstract：:While gene expression dynamics have been extensively cataloged during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and post-transcriptional changes in HSCs during development, we leve...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2018.03.012

    authors： Cesana M,Guo MH,Cacchiarelli D,Wahlster L,Barragan J,Doulatov S,Vo LT,Salvatori B,Trapnell C,Clement K,Cahan P,Tsanov KM,Sousa PM,Tazon-Vega B,Bolondi A,Giorgi FM,Califano A,Rinn JL,Meissner A,Hirschhorn JN,Daley

    更新日期：2018-04-05 00:00:00

  • Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells.

    abstract：:In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 genes. We were able to predict causal variants for these expression quantitative trait loci (e...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2017.03.009

    authors： DeBoever C,Li H,Jakubosky D,Benaglio P,Reyna J,Olson KM,Huang H,Biggs W,Sandoval E,D'Antonio M,Jepsen K,Matsui H,Arias A,Ren B,Nariai N,Smith EN,D'Antonio-Chronowska A,Farley EK,Frazer KA

    更新日期：2017-04-06 00:00:00

  • Naive versus Primed: It's Now Three-Dimensional.

    abstract：:We are only beginning to understand the higher-order chromatin structure of pluripotent stem cells and its relevance to cell fate. Three recent studies used different approaches to reconstruct the 3D chromatin landscape of naive and primed pluripotent cells, unveiling common features as well as differences between the...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2016.01.014

    authors： Wei Z,Lu W

    更新日期：2016-02-04 00:00:00

  • A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.

    abstract：:SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental pl...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2020.06.015

    authors： Yang L,Han Y,Nilsson-Payant BE,Gupta V,Wang P,Duan X,Tang X,Zhu J,Zhao Z,Jaffré F,Zhang T,Kim TW,Harschnitz O,Redmond D,Houghton S,Liu C,Naji A,Ciceri G,Guttikonda S,Bram Y,Nguyen DT,Cioffi M,Chandar V,Hoagl

    更新日期：2020-07-02 00:00:00

  • Klf2 is an essential factor that sustains ground state pluripotency.

    abstract：:The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways. While Gsk3 inhibition has been attribut...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.04.015

    authors： Yeo JC,Jiang J,Tan ZY,Yim GR,Ng JH,Göke J,Kraus P,Liang H,Gonzales KA,Chong HC,Tan CP,Lim YS,Tan NS,Lufkin T,Ng HH

    更新日期：2014-06-05 00:00:00

  • An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells.

    abstract：:Adipose stromal cells (ASCs) serve as mesenchymal progenitors in white adipose tissue (WAT). Intercellular interactions involving ASCs have remained obscure. By merging phage display technology with fluorescence-activated cell sorting (FACS), we screened a combinatorial library for peptides that target mouse ASCs in v...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2011.05.017

    authors： Daquinag AC,Zhang Y,Amaya-Manzanares F,Simmons PJ,Kolonin MG

    更新日期：2011-07-08 00:00:00

  • High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

    abstract：:Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation. Here, we present a fully automated, HTS-compatible platform for enhanced differentiation and...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2018.04.022

    authors： Czerniecki SM,Cruz NM,Harder JL,Menon R,Annis J,Otto EA,Gulieva RE,Islas LV,Kim YK,Tran LM,Martins TJ,Pippin JW,Fu H,Kretzler M,Shankland SJ,Himmelfarb J,Moon RT,Paragas N,Freedman BS

    更新日期：2018-06-01 00:00:00

  • Ch-ch-changes: hormones link stem cell differentiation with metabolic flux.

    abstract：:Emerging evidence strongly suggests that stem cells and their differentiated progeny display distinct metabolic profiles, but how metabolic changes are coupled with organogenesis has remained unclear. Homem et al. (2014) now reveal a hormone-dependent pathway that couples metabolic changes with stem cell differentiati...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2014.08.006

    authors： Buttitta L,Lee CY

    更新日期：2014-09-04 00:00:00

  • Single-Cell Transcriptomics Meets Lineage Tracing.

    abstract：:Reconstructing lineage relationships between cells within a tissue or organism is a long-standing aim in biology. Traditionally, lineage tracing has been achieved through the (genetic) labeling of a cell followed by the tracking of its offspring. Currently, lineage trajectories can also be predicted using single-cell ...

    journal_title：Cell stem cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.stem.2018.04.014

    authors： Kester L,van Oudenaarden A

    更新日期：2018-08-02 00:00:00

  • Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming.

    abstract：:Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcript...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2019.09.007

    authors： Hu X,Guo S

    更新日期：2019-10-03 00:00:00