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Single-Cell Transcriptomics Meets Lineage Tracing.

Abstract：

:Reconstructing lineage relationships between cells within a tissue or organism is a long-standing aim in biology. Traditionally, lineage tracing has been achieved through the (genetic) labeling of a cell followed by the tracking of its offspring. Currently, lineage trajectories can also be predicted using single-cell transcriptomics. Although single-cell transcriptomics provides detailed phenotypic information, the predicted lineage trajectories do not necessarily reflect genetic relationships. Recently, techniques have been developed that unite these strategies. In this Review, we discuss transcriptome-based lineage trajectory prediction algorithms, single-cell genetic lineage tracing, and the promising combination of these techniques for stem cell and cancer research.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Kester L,van Oudenaarden A

doi

10.1016/j.stem.2018.04.014

subject

Has Abstract

pub_date

2018-08-02 00:00:00

pages

166-179

issue

2

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(18)30176-0

journal_volume

23

pub_type

杂志文章,评审

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