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Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.

Abstract：

:The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficiently infects human neural progenitor cells (hNPCs) derived from induced pluripotent stem cells. Infected hNPCs further release infectious ZIKV particles. Importantly, ZIKV infection increases cell death and dysregulates cell-cycle progression, resulting in attenuated hNPC growth. Global gene expression analysis of infected hNPCs reveals transcriptional dysregulation, notably of cell-cycle-related pathways. Our results identify hNPCs as a direct ZIKV target. In addition, we establish a tractable experimental model system to investigate the impact and mechanism of ZIKV on human brain development and provide a platform to screen therapeutic compounds.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Tang H,Hammack C,Ogden SC,Wen Z,Qian X,Li Y,Yao B,Shin J,Zhang F,Lee EM,Christian KM,Didier RA,Jin P,Song H,Ming GL

doi

10.1016/j.stem.2016.02.016

subject

Has Abstract

pub_date

2016-05-05 00:00:00

pages

587-90

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(16)00106-5

journal_volume

18

pub_type

杂志文章

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