Abstract：
:Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling pathways preferentially enriched in GSCs. We identified integrin α7 (ITGA7) as a major laminin receptor in GSCs and in primary high-grade glioma specimens. Analyses of mRNA profiles in comprehensive datasets revealed that high ITGA7 expression negatively correlated with survival of patients with both low- and high-grade glioma. In vitro and in vivo analyses showed that ITGA7 plays a key functional role in growth and invasiveness of GSCs. We also found that targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion. Our data, therefore, highlight ITGA7 as a glioblastoma biomarker and candidate therapeutic target.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Haas TL,Sciuto MR,Brunetto L,Valvo C,Signore M,Fiori ME,di Martino S,Giannetti S,Morgante L,Boe A,Patrizii M,Warnken U,Schnölzer M,Ciolfi A,Di Stefano C,Biffoni M,Ricci-Vitiani L,Pallini R,De Maria Rdoi
10.1016/j.stem.2017.04.009subject
Has Abstractpub_date
2017-07-06 00:00:00pages
35-50.e9issue
1eissn
1934-5909issn
1875-9777pii
S1934-5909(17)30137-6journal_volume
21pub_type
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