Environmental and genetic modulation of the phenotypic expression of antibiotic resistance.

abstract：:Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene. The antitoxin generally acts as a transcriptional self-repressor, whereas the toxin acts as a co-repressor, both proteins consti...

journal_title：FEMS microbiology reviews

authors： Chan WT,Balsa D,Espinosa M

更新日期：2015-07-01 00:00:00

abstract：:Wall teichoic acids (WTAs) are charged glycopolymers containing phosphodiester-linked polyol units and represent one of the major components of Gram-positive cell envelope. WTAs have important physiological functions in cell division, gene transfer, surface adhesion, drug resistance, and biofilm formation, and are cri...

journal_title：FEMS microbiology reviews

authors： Wu X,Han J,Gong G,Koffas MAG,Zha J

更新日期：2020-12-03 00:00:00

abstract：:Antibiotics are the most common type of medication prescribed to children, including infants, in the Western world. While use of antibiotics has transformed previously lethal infections into relatively minor diseases, antibiotic treatments can have adverse effects as well. It has been shown in children, adults and ani...

journal_title：FEMS microbiology reviews

authors： Neuman H,Forsythe P,Uzan A,Avni O,Koren O

更新日期：2018-07-01 00:00:00

abstract：:Methanogens form a very large and diverse group of microorganisms within the domain of the Archaea. Energy for their growth is obtained by the reduction of a variety of substrates into methane. Several genes, coding for enzymes involved in methanogenesis or in the central metabolism have been cloned and studied. The m...

journal_title：FEMS microbiology reviews

authors： Eggen RI

更新日期：1994-10-01 00:00:00

abstract：:The species concept is a recurrent controversial issue that preoccupies philosophers as well as biologists of all disciplines. Prokaryotic species concept has its own history and results from a series of empirical improvements parallel to the development of the techniques of analysis. Among the microbial taxonomists, ...

journal_title：FEMS microbiology reviews

authors： Rosselló-Mora R,Amann R

更新日期：2001-01-01 00:00:00

abstract：:Gene regB of bacteriophage T4 encodes a sequence-specific endoribonuclease which introduces cuts in early phage messenger RNAs. In most cases, cutting takes place in the middle of the tetranucleotide GGAG. Efficient cleavages occur in the motifs located in intergenic regions, some of them being Shine-Dalgarno sequence...

journal_title：FEMS microbiology reviews

authors： Sanson B,Uzan M

更新日期：1995-08-01 00:00:00

abstract：:Pathogenicity and symbiosis are central to bacteria-host interactions. Although several human pathogens have been subjected to functional genomic analysis, we still understand little about bacteria-invertebrate interactions despite their ecological prevalence. Advances in our knowledge of this area are often hindered ...

journal_title：FEMS microbiology reviews

authors： ffrench-Constant R,Waterfield N,Daborn P,Joyce S,Bennett H,Au C,Dowling A,Boundy S,Reynolds S,Clarke D

更新日期：2003-01-01 00:00:00

abstract：:Pseudomonas putida is a gram-negative rod-shaped gammaproteobacterium that is found throughout various environments. Members of the species P. putida show a diverse spectrum of metabolic activities, which is indicative of their adaptation to various niches, which includes the ability to live in soils and sediments con...

journal_title：FEMS microbiology reviews

authors： Wu X,Monchy S,Taghavi S,Zhu W,Ramos J,van der Lelie D

更新日期：2011-03-01 00:00:00

abstract：:Antibiotic resistance is one of the few examples of evolution that can be addressed experimentally. The present review analyses this resistance, focusing on the networks that regulate its acquisition and its effect on bacterial physiology. It is widely accepted that antibiotics and antibiotic resistance genes play fun...

journal_title：FEMS microbiology reviews

authors： Martinez JL,Fajardo A,Garmendia L,Hernandez A,Linares JF,Martínez-Solano L,Sánchez MB

更新日期：2009-01-01 00:00:00

abstract：:Meningococcal disease is a serious and rapidly progressing illness. It is therefore very important to monitor changes in the level of antibiotic susceptibility among clinical isolates. Different aspects such as interpretation of laboratory results, determination of breakpoints predicting treatment failure as well as d...

journal_title：FEMS microbiology reviews

authors： Vázquez JA,Enriquez R,Abad R,Alcalá B,Salcedo C,Arreaza L

更新日期：2007-01-01 00:00:00

abstract：:Toxin-antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant plasmids and inducing persistence formation. Generally, activities of the toxins are neutralised by their conjugate antitoxins. In contras...

journal_title：FEMS microbiology reviews

authors： Yang QE,Walsh TR

更新日期：2017-05-01 00:00:00

abstract：:Protists include all eukaryotes except plants, fungi and animals. They are an essential, yet often forgotten, component of the soil microbiome. Method developments have now furthered our understanding of the real taxonomic and functional diversity of soil protists. They occupy key roles in microbial foodwebs as consum...

journal_title：FEMS microbiology reviews

authors： Geisen S,Mitchell EAD,Adl S,Bonkowski M,Dunthorn M,Ekelund F,Fernández LD,Jousset A,Krashevska V,Singer D,Spiegel FW,Walochnik J,Lara E

更新日期：2018-05-01 00:00:00

abstract：:Lack of known mechanisms of protection against Staphylococcus aureus in humans is hindering development of efficacious vaccines. Preclinical as well as clinical data suggest that antibodies play an important role against S. aureus. For instance, certain hypogammaglobulinaemic patients are at increased risk of staphylo...

journal_title：FEMS microbiology reviews

authors： Pozzi C,Lofano G,Mancini F,Soldaini E,Speziale P,De Gregorio E,Rappuoli R,Bertholet S,Grandi G,Bagnoli F

更新日期：2015-09-01 00:00:00

abstract：:The genus Rickettsia (Alphaproteobacteria, Rickettsiales, Rickettsiaceae) is comprised of obligate intracellular parasites, with virulent species of interest both as causes of emerging infectious diseases and for their potential deployment as bioterrorism agents. Currently, there are no effective commercially availabl...

journal_title：FEMS microbiology reviews

authors： Gillespie JJ,Kaur SJ,Rahman MS,Rennoll-Bankert K,Sears KT,Beier-Sexton M,Azad AF

更新日期：2015-01-01 00:00:00

abstract：:The head assembly pathway of bacteriophage HK97 shares many features with head assembly pathways determined for other dsDNA phages, and it also provides examples of novel variations on the basic theme. We describe aspects of two specific steps in the assembly pathway, the covalent cross-linking among the assembled hea...

journal_title：FEMS microbiology reviews

authors： Duda RL,Martincic K,Xie Z,Hendrix RW

更新日期：1995-08-01 00:00:00

abstract：:Based on structural, biochemical, and genetic data, the soluble diiron monooxygenases can be divided into four groups: the soluble methane monooxygenases, the Amo alkene monooxygenase of Rhodococcus corallinus B-276, the phenol hydroxylases, and the four-component alkene/aromatic monooxygenases. The limited phylogenet...

journal_title：FEMS microbiology reviews

authors： Leahy JG,Batchelor PJ,Morcomb SM

更新日期：2003-10-01 00:00:00

abstract：:Deeper sequencing and improved bioinformatics in conjunction with single-cell and metagenomic approaches continue to illuminate undercharacterized environmental microbial communities. This has propelled the 'who is there, and what might they be doing' paradigm to the uncultivated and has already radically changed the ...

journal_title：FEMS microbiology reviews

authors： Doud DFR,Woyke T

更新日期：2017-07-01 00:00:00

abstract：:The production of the fusion protein staphylococcal protein A/E. coli beta-galactosidase in Escherichia coli was studied in batch and fed batch cultivations. Batch cultivation of a recombinant E. coli strain yielded a final cell dry weight of 16.4 g l-1 with a final intracellular product concentration of recombinant p...

journal_title：FEMS microbiology reviews

authors： Strandberg L,Andersson L,Enfors SO

更新日期：1994-05-01 00:00:00

abstract：:What a living organism looks like and how it works and what are its components-all this is encoded on DNA, the genetic blueprint. Consequently, the way to change an organism is to change its genetic information. Since the first pieces of recombinant DNA have been used to transform cells in the 1970s, this approach has...

journal_title：FEMS microbiology reviews

authors： Schindler D,Waldminghaus T

更新日期：2015-11-01 00:00:00

abstract：:The initial step of methanogenesis from CO2 is the formation of formyl-methanofuran (formyl-MFR) from methanofuran (MFR), CO2 and H2. The enzymology of this novel type of CO2 fixation reaction has been difficult to study because formyl-MFR synthesis is subject to a complex activation. Recently, however, a number of ad...

journal_title：FEMS microbiology reviews

authors： Bobik TA,DiMarco AA,Wolfe RS

更新日期：1990-12-01 00:00:00

abstract：:Purine salvage is an essential function for all obligate parasitic protozoa studied to date and most are also capable of efficient uptake of preformed pyrimidines. Much progress has been made in the identification and characterisation of protozoan purine and pyrimidine transporters. While the genes encoding protozoan ...

journal_title：FEMS microbiology reviews

authors： de Koning HP,Bridges DJ,Burchmore RJ

更新日期：2005-11-01 00:00:00

abstract：:Water is one of the most important bacterial habitats on Earth. As such, water represents also a major way of dissemination of bacteria between different environmental compartments. Human activities led to the creation of the so-called urban water cycle, comprising different sectors (waste, surface, drinking water), a...

journal_title：FEMS microbiology reviews

authors： Vaz-Moreira I,Nunes OC,Manaia CM

更新日期：2014-07-01 00:00:00

abstract：:Expression cloning is a relatively new method for fast and efficient cloning of enzyme genes from fungi that are known to make complex enzyme mixtures. In contrast to traditional cloning methods that are usually dependent on knowledge of at least a partial amino acid sequence in order to synthesize appropriate DNA pro...

journal_title：FEMS microbiology reviews

authors： Dalbøge H

更新日期：1997-08-01 00:00:00

abstract：:Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and interindividual heterogeneity of the microbiome represent experimental limitations, especially in human cross-sectional studies. Therefore, rodent models represent an in...

journal_title：FEMS microbiology reviews

authors： Laukens D,Brinkman BM,Raes J,De Vos M,Vandenabeele P

更新日期：2016-01-01 00:00:00

abstract：:The genome of bacteriophage fd has been engineered to allow foreign amino acid sequences to be displayed in the exposed N-terminal segment of the major coat protein in the virus particle: small peptides can be encoded directly; larger peptides are encoded in hybrid virions, in which wild-type coat protein subunits are...

journal_title：FEMS microbiology reviews

authors： Perham RN,Terry TD,Willis AE,Greenwood J,di Marzo Veronese F,Appella E

更新日期：1995-08-01 00:00:00

abstract：:The increasing numbers of characterized base-pairing small RNAs (sRNAs) and the identification of these regulators in a broad range of bacteria are allowing comparisons between species and explorations of sRNA evolution. In this review, we describe some examples of trans-encoded base-pairing sRNAs that are species-spe...

journal_title：FEMS microbiology reviews

authors： Updegrove TB,Shabalina SA,Storz G

更新日期：2015-05-01 00:00:00

abstract：:O-antigen polysaccharide is a major immunogenic feature of the lipopolysaccharide of Gram-negative bacteria, and most species produce a large variety of forms that differ substantially from one another. There are 18 known O-antigen forms in the Yersinia pseudotuberculosis complex, which are typical in being composed o...

journal_title：FEMS microbiology reviews

authors： Kenyon JJ,Cunneen MM,Reeves PR

更新日期：2017-03-01 00:00:00

abstract：:Lipopeptides constitute a structurally diverse group of metabolites produced by various bacterial and fungal genera. In the past decades, research on lipopeptides has been fueled by their antimicrobial, antitumour, immunosuppressant and surfactant activities. However, the natural functions of lipopeptides in the lifes...

journal_title：FEMS microbiology reviews

authors： Raaijmakers JM,De Bruijn I,Nybroe O,Ongena M

更新日期：2010-11-01 00:00:00

abstract：:Most bacteria pathogenic for humans have closely related nonpathogenic counterparts that live as saprophytes, commensals or even symbionts (mutualists) in similar or different habitats. The knowledge of how these bacteria adapt their metabolism to the preferred habitats is critical for our understanding of pathogenesi...

journal_title：FEMS microbiology reviews

authors： Fuchs TM,Eisenreich W,Heesemann J,Goebel W

更新日期：2012-03-01 00:00:00

abstract：:A high level of anti-HCV is generally associated with viral replication and the number of recognized epitopes appears to be correlated with the viral charge. Nevertheless, the absence of detectable antibodies in about 60% of patients during the acute phase of the disease and in 10% of chronically infected (generally i...

journal_title：FEMS microbiology reviews

authors： Pillot J,Rioche M,Lazizi Y

更新日期：1994-07-01 00:00:00