Abstract：
:O-antigen polysaccharide is a major immunogenic feature of the lipopolysaccharide of Gram-negative bacteria, and most species produce a large variety of forms that differ substantially from one another. There are 18 known O-antigen forms in the Yersinia pseudotuberculosis complex, which are typical in being composed of multiple copies of a short oligosaccharide called an O unit. The O-antigen gene clusters are located between the hemH and gsk genes, and are atypical as 15 of them are closely related, each having one of five downstream gene modules for alternative main-chain synthesis, and one of seven upstream modules for alternative side-branch sugar synthesis. As a result, many of the genes are in more than one gene cluster. The gene order in each module is such that, in general, the earlier a gene product functions in O-unit synthesis, the closer the gene is to the 5΄ end for side-branch modules or the 3΄ end for main-chain modules. We propose a model whereby natural selection could generate the observed pattern in gene order, a pattern that has also been observed in other species.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Kenyon JJ,Cunneen MM,Reeves PRdoi
10.1093/femsre/fux002subject
Has Abstractpub_date
2017-03-01 00:00:00pages
200-217issue
2eissn
0168-6445issn
1574-6976pii
2996588journal_volume
41pub_type
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