Abstract:
:Dengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a member of the Flaviviridae family. Its worldwide incidence is now a major health problem, with 2.5 billion people living in risk areas. In this review, we integrate the structural rearrangements of each viral protein and their functions in all the steps of virus entry into the host cells. We describe in detail the putative receptors and attachment factors in mammalian and mosquito cells, and the recognition of viral immunocomplexes via Fcγ receptor in immune cells. We also discuss that virus internalization might occur through distinct entry pathways, including clathrin-mediated or non-classical clathrin-independent endocytosis, depending on the host cell and virus serotype or strain. The implications of viral maturation in virus entry are also explored. Finally, we discuss the mechanisms of viral genome access to the cytoplasm. This includes the role of low pH-induced conformational changes in the envelope protein that mediate membrane fusion, and original insights raised by our recent work that supports the hypothesis that capsid protein would also be an active player in this process, acting on viral genome translocation into the cytoplasm.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Cruz-Oliveira C,Freire JM,Conceição TM,Higa LM,Castanho MA,Da Poian ATdoi
10.1093/femsre/fuu004subject
Has Abstractpub_date
2015-03-01 00:00:00pages
155-70issue
2eissn
0168-6445issn
1574-6976pii
fuu004journal_volume
39pub_type
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journal_title:FEMS microbiology reviews
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journal_title:FEMS microbiology reviews
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abstract::Arsenic compounds have been abundant at near toxic levels in the environment since the origin of life. In response, microbes have evolved mechanisms for arsenic resistance and enzymes that oxidize As(III) to As(V) or reduce As(V) to As(III). Formation and degradation of organoarsenicals, for example methylarsenic comp...
journal_title:FEMS microbiology reviews
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doi:10.1111/j.1574-6976.2002.tb00617.x
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journal_title:FEMS microbiology reviews
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doi:10.1111/1574-6976.12015
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journal_title:FEMS microbiology reviews
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journal_title:FEMS microbiology reviews
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abstract::Meningococcal disease is a serious and rapidly progressing illness. It is therefore very important to monitor changes in the level of antibiotic susceptibility among clinical isolates. Different aspects such as interpretation of laboratory results, determination of breakpoints predicting treatment failure as well as d...
journal_title:FEMS microbiology reviews
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doi:10.1111/j.1574-6976.2006.00049.x
更新日期:2007-01-01 00:00:00
abstract::Plant cell wall consists mainly of the large biopolymers cellulose, hemicellulose, lignin and pectin. These biopolymers are degraded by many microorganisms, in particular filamentous fungi, with the aid of extracellular enzymes. Filamentous fungi have a key role in degradation of the most abundant biopolymers found in...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1016/j.femsre.2004.11.006
更新日期:2005-09-01 00:00:00
abstract::Metals are required cofactors for numerous fundamental processes that are essential to both pathogen and host. They are coordinated in enzymes responsible for DNA replication and transcription, relief from oxidative stress, and cellular respiration. However, excess transition metals can be toxic due to their ability t...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/1574-6976.12087
更新日期:2014-11-01 00:00:00
abstract::Small cells dominate photosynthetic biomass and primary production in many marine ecosystems. Traditionally, picoplankton refers to cells < or =2 microm. Here we extend the size range of the organisms considered to 3 microm, a threshold often used operationally in field studies. While the prokaryotic component of pico...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2008.00121.x
更新日期:2008-08-01 00:00:00
abstract::The production of the fusion protein staphylococcal protein A/E. coli beta-galactosidase in Escherichia coli was studied in batch and fed batch cultivations. Batch cultivation of a recombinant E. coli strain yielded a final cell dry weight of 16.4 g l-1 with a final intracellular product concentration of recombinant p...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章
doi:10.1111/j.1574-6976.1994.tb00072.x
更新日期:1994-05-01 00:00:00
abstract::The P(II) proteins are one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably, P(II) proteins control the activities of a diverse rang...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2012.00351.x
更新日期:2013-03-01 00:00:00
abstract::In the present review, we aim to provide a general introduction to different facets of the arms race between pathogens and their hosts/environment, emphasizing its evolutionary aspects. We focus on vector-borne parasitic protozoa, which have to adapt to both invertebrate and vertebrate hosts. Using Leishmania, Trypano...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuw018
更新日期:2016-09-01 00:00:00
abstract::Water is one of the most important bacterial habitats on Earth. As such, water represents also a major way of dissemination of bacteria between different environmental compartments. Human activities led to the creation of the so-called urban water cycle, comprising different sectors (waste, surface, drinking water), a...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/1574-6976.12062
更新日期:2014-07-01 00:00:00
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journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2001.tb00571.x
更新日期:2001-01-01 00:00:00
abstract::Bacillus thuringiensis is a well-known biopesticide that has been used for more than 80 years. This spore-forming bacterium belongs to the group of Bacillus cereus that also includes, among others, emetic and diarrheic pathotypes of B. cereus, the animal pathogen Bacillus anthracis and the psychrotolerant Bacillus wei...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章
doi:10.1093/femsre/fuy034
更新日期:2018-11-01 00:00:00
abstract::Antibiotic resistance is one of the few examples of evolution that can be addressed experimentally. The present review analyses this resistance, focusing on the networks that regulate its acquisition and its effect on bacterial physiology. It is widely accepted that antibiotics and antibiotic resistance genes play fun...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2008.00142.x
更新日期:2009-01-01 00:00:00
abstract::Purine salvage is an essential function for all obligate parasitic protozoa studied to date and most are also capable of efficient uptake of preformed pyrimidines. Much progress has been made in the identification and characterisation of protozoan purine and pyrimidine transporters. While the genes encoding protozoan ...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1016/j.femsre.2005.03.004
更新日期:2005-11-01 00:00:00
abstract::Ribonuclease P is the endonuclease required for generating the mature tRNA 5'-end. The ribonucleoprotein character of this enzyme has now been proven in most organisms and organelles. Exceptions, however, are still the chloroplasts, plant nuclei and animal mitochondria where no associated RNAs have been detected to da...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.1999.tb00406.x
更新日期:1999-06-01 00:00:00
abstract::Magnetotactic bacteria (MB) are remarkable organisms with the ability to exploit the earth's magnetic field for navigational purposes. To do this, they build specialized compartments called magnetosomes that consist of a lipid membrane and a crystalline magnetic mineral. These organisms have the potential to serve as ...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2011.00315.x
更新日期:2012-01-01 00:00:00
abstract::Thioredoxin is a small (Mr 12,000) ubiquitous redox protein with the conserved active site structure: -Trp-Cys-Gly-Pro-Cys-. The oxidized form (Trx-S2) contains a disulfide bridge which is reduced by NADPH and thioredoxin reductase; the reduced form [Trx(SH)2] is a powerful protein disulfide oxidoreductase. Thioredoxi...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6968.1988.tb02747.x
更新日期:1988-12-01 00:00:00
abstract::Lack of known mechanisms of protection against Staphylococcus aureus in humans is hindering development of efficacious vaccines. Preclinical as well as clinical data suggest that antibodies play an important role against S. aureus. For instance, certain hypogammaglobulinaemic patients are at increased risk of staphylo...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuv024
更新日期:2015-09-01 00:00:00
abstract::Expression cloning is a relatively new method for fast and efficient cloning of enzyme genes from fungi that are known to make complex enzyme mixtures. In contrast to traditional cloning methods that are usually dependent on knowledge of at least a partial amino acid sequence in order to synthesize appropriate DNA pro...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.1997.tb00343.x
更新日期:1997-08-01 00:00:00
abstract::In the last decade, a variety of ribosomally synthesized antimicrobial peptides or bacteriocins produced by lactic acid bacteria have been identified and characterized. As a result of these studies, insight has been gained into fundamental aspects of biology and biochemistry such as producer self protection, membrane-...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2000.tb00534.x
更新日期:2000-01-01 00:00:00
abstract::Microbial networks are an increasingly popular tool to investigate microbial community structure, as they integrate multiple types of information and may represent systems-level behaviour. Interpreting these networks is not straightforward, and the biological implications of network properties are unclear. Analysis of...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuy030
更新日期:2018-11-01 00:00:00
abstract::Repeated sequences are commonly present in the sites for DNA replication initiation in bacterial, archaeal, and eukaryotic replicons. Those motifs are usually the binding places for replication initiation proteins or replication regulatory factors. In prokaryotic replication origins, the most abundant repeated sequenc...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2011.00300.x
更新日期:2012-03-01 00:00:00
abstract::Gram-positive bacteria have developed elaborate mechanisms to control ammonium assimilation, at the levels of both transcription and enzyme activity. In this review, the common and specific mechanisms of nitrogen assimilation and regulation in Gram-positive bacteria are summarized and compared for the genera Bacillus,...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1574-6976.2010.00216.x
更新日期:2010-07-01 00:00:00
abstract::Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein production processes, have emerged as unanticipated, highly tunable models for the scrutiny of the physiology and arc...
journal_title:FEMS microbiology reviews
pub_type: 杂志文章,评审
doi:10.1093/femsre/fuy038
更新日期:2019-01-01 00:00:00