Abstract:
:Arsenic compounds have been abundant at near toxic levels in the environment since the origin of life. In response, microbes have evolved mechanisms for arsenic resistance and enzymes that oxidize As(III) to As(V) or reduce As(V) to As(III). Formation and degradation of organoarsenicals, for example methylarsenic compounds, occur. There is a global arsenic geocycle, where microbial metabolism and mobilization (or immobilization) are important processes. Recent progress in studies of the ars operon (conferring resistance to As(III) and As(V)) in many bacterial types (and related systems in Archaea and yeast) and new understanding of arsenite oxidation and arsenate reduction by respiratory-chain-linked enzyme complexes has been substantial. The DNA sequencing and protein crystal structures have established the convergent evolution of three classes of arsenate reductases (that is classes of arsenate reductases are not of common evolutionary origin). Proposed reaction mechanisms in each case involve three cysteine thiols and S-As bond intermediates, so convergent evolution to similar mechanisms has taken place.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Mukhopadhyay R,Rosen BP,Phung LT,Silver Sdoi
10.1111/j.1574-6976.2002.tb00617.xsubject
Has Abstractpub_date
2002-08-01 00:00:00pages
311-25issue
3eissn
0168-6445issn
1574-6976pii
S0168644502001122journal_volume
26pub_type
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