Abstract：
:The peroxisomal membrane compartmentalizes specific metabolic functions in the intermediary metabolism of various aerobic eukarya. In yeast, peroxisomal membranes are typified by their small width (+/- 7-8 nm) and absence of large integral membrane proteins in freeze-etch replicas. They show a unique polypeptide profile which, in contrast to their phospholipid composition, differs from that of other membranes in the cell. Part of these proteins are substrate-inducible and are probably related to specific peroxisomal function(s). In vivo, the observed proton motive force across the peroxisomal membrane may play a role in the function of the organelle in that it contributes to the driving force required for selective transport of various enzyme substrates and/or metabolic intermediates. To date only few peroxisomal membrane proteins (PMPs) have been functionally characterized. A major constitutive 31-kDa PMP present in the peroxisomal membrane of Hansenula polymorpha has been purified and was shown to display pore-forming properties. In addition, a peroxisomal H(+)-ATPase has been identified which most probably is involved in the generation/maintenance of the in vivo pH gradient across the peroxisomal membrane. Other functions of peroxisomal membrane proteins remain obscure although the first genes encoding yeast PMPs are now being cloned and sequenced. Studies on peroxisome-deficient yeast mutants revealed that specific peroxisome functions are strictly dependent on the intactness of the peroxisomal membrane. In this contribution several examples are presented of metabolic disorders due to peroxisomal malfunction in yeast.
journal_name
FEMS Microbiol Revjournal_title
FEMS microbiology reviewsauthors
Sulter GJ,Harder W,Veenhuis Mdoi
10.1111/j.1574-6976.1993.tb00002.xsubject
Has Abstractpub_date
1993-08-01 00:00:00pages
285-96issue
4eissn
0168-6445issn
1574-6976journal_volume
11pub_type
杂志文章,评审abstract：:The P(II) proteins are one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably, P(II) proteins control the activities of a diverse rang...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2012.00351.x
更新日期：2013-03-01 00:00:00
abstract：:Purine salvage is an essential function for all obligate parasitic protozoa studied to date and most are also capable of efficient uptake of preformed pyrimidines. Much progress has been made in the identification and characterisation of protozoan purine and pyrimidine transporters. While the genes encoding protozoan ...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1016/j.femsre.2005.03.004
更新日期：2005-11-01 00:00:00
abstract：:Arsenic compounds have been abundant at near toxic levels in the environment since the origin of life. In response, microbes have evolved mechanisms for arsenic resistance and enzymes that oxidize As(III) to As(V) or reduce As(V) to As(III). Formation and degradation of organoarsenicals, for example methylarsenic comp...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2002.tb00617.x
更新日期：2002-08-01 00:00:00
abstract：:Heat-shock proteins (hsps) have been identified as molecular chaperones conserved between microbes and man and grouped by their molecular mass and high degree of amino acid homology. This article reviews the major hsps of Saccharomyces cerevisiae, their interactions with trehalose, the effect of fermentation and the r...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2005.00001.x
更新日期：2006-01-01 00:00:00
abstract：:Our knowledge regarding the nature and development of microbial biofilms has grown significantly since the first report of these communities by Antonie van Leeuwenhoek in the late 1600s. Nevertheless, most biofilm studies examine mono-species cultures, whereas nearly all biofilm communities in nature comprise a variet...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2012.00325.x
更新日期：2012-09-01 00:00:00
abstract：:Lipopeptides constitute a structurally diverse group of metabolites produced by various bacterial and fungal genera. In the past decades, research on lipopeptides has been fueled by their antimicrobial, antitumour, immunosuppressant and surfactant activities. However, the natural functions of lipopeptides in the lifes...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2010.00221.x
更新日期：2010-11-01 00:00:00
abstract：:The initial step of methanogenesis from CO2 is the formation of formyl-methanofuran (formyl-MFR) from methanofuran (MFR), CO2 and H2. The enzymology of this novel type of CO2 fixation reaction has been difficult to study because formyl-MFR synthesis is subject to a complex activation. Recently, however, a number of ad...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1016/0378-1097(90)90473-4
更新日期：1990-12-01 00:00:00
abstract：:Legionella pneumophila is naturally found in fresh water were the bacteria parasitize within protozoa. It also survives planctonically in water or biofilms. Upon aerosol formation via man-made water systems, L. pneumophila can enter the human lung and cause a severe form of pneumonia, called Legionnaires' disease. The...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2002.tb00607.x
更新日期：2002-06-01 00:00:00
abstract：:The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been elucidated in great detail. This has led to important new concepts and insight into nutrient-controlled cellular regulation. Major highlights i...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/1574-6976.12065
更新日期：2014-03-01 00:00:00
abstract：:Small regulatory RNAs have been identified in a wide range of organisms, where they modify mRNA stability, translation or protein function. Small RNA regulators (sRNAs) either pair with mRNA targets or modify protein activities. Here we discuss current knowledge of the various proteins that interact with RNA regulator...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2007.00079.x
更新日期：2007-09-01 00:00:00
abstract：:Human protein kinase C (PKC) isoforms have been implicated in diseases such as Alzheimer's, diabetes and cancers. In contrast to mammals, which have at least nine genes, fungi have only one or two. The yeast Saccharomyces cerevisiae produces only a single Pkc1 and is employed in the study of specific human isozymes, i...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1093/femsre/fux051
更新日期：2018-01-01 00:00:00
abstract：:Human enteric pathogenic viruses can enter the environment through discharge of waste materials from infected persons, and be transmitted back to susceptible persons to continue the cycle of disease. Contamination of food with viruses may also promote disease outbreaks. A number of studies have investigated the surviv...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1016/j.femsre.2004.02.001
更新日期：2004-10-01 00:00:00
abstract：:The gram-negative bacterium Proteus mirabilis can exist in either of two cell types, a vegetative cell characterized as a short rod and a highly elongated and hyperflagellated swarmer cell. This differentiation is triggered by growth on solid surfaces and multiple inputs are sensed by the cell to initiate the differen...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2010.00229.x
更新日期：2010-09-01 00:00:00
abstract：:Metals are required cofactors for numerous fundamental processes that are essential to both pathogen and host. They are coordinated in enzymes responsible for DNA replication and transcription, relief from oxidative stress, and cellular respiration. However, excess transition metals can be toxic due to their ability t...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/1574-6976.12087
更新日期：2014-11-01 00:00:00
abstract：:Protists include all eukaryotes except plants, fungi and animals. They are an essential, yet often forgotten, component of the soil microbiome. Method developments have now furthered our understanding of the real taxonomic and functional diversity of soil protists. They occupy key roles in microbial foodwebs as consum...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1093/femsre/fuy006
更新日期：2018-05-01 00:00:00
abstract：:Pseudomonas putida is a gram-negative rod-shaped gammaproteobacterium that is found throughout various environments. Members of the species P. putida show a diverse spectrum of metabolic activities, which is indicative of their adaptation to various niches, which includes the ability to live in soils and sediments con...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2010.00249.x
更新日期：2011-03-01 00:00:00
abstract：:More than a century ago, the term 'virus' was introduced to describe infectious agents that are invisible by light microscopy and capable of passing through sterilizing filters. In addition to their extremely small size, most viruses have minimal genomes and gene contents, and rely almost entirely on host cell-encoded...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1093/femsre/fuv037
更新日期：2015-11-01 00:00:00
abstract：:Nickel is an essential nutrient for selected microorganisms where it participates in a variety of cellular processes. Many microbes are capable of sensing cellular nickel ion concentrations and taking up this nutrient via nickel-specific permeases or ATP-binding cassette-type transport systems. The metal ion is specif...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1016/S0168-6445(03)00042-1
更新日期：2003-06-01 00:00:00
abstract：:Wall teichoic acids (WTAs) are charged glycopolymers containing phosphodiester-linked polyol units and represent one of the major components of Gram-positive cell envelope. WTAs have important physiological functions in cell division, gene transfer, surface adhesion, drug resistance, and biofilm formation, and are cri...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章
doi：10.1093/femsre/fuaa064
更新日期：2020-12-03 00:00:00
abstract：:Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein production processes, have emerged as unanticipated, highly tunable models for the scrutiny of the physiology and arc...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1093/femsre/fuy038
更新日期：2019-01-01 00:00:00
abstract：:A number of peptidases and proteases have been identified in Escherichia coli. Although their specific physiological roles are often not known, some of them have been shown to be involved in: the maturation of nascent polypeptide chains; the maturation of protein precursors; the signal peptide processing of exported p...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1016/0168-6445(89)90035-1
更新日期：1989-09-01 00:00:00
abstract：:Small cells dominate photosynthetic biomass and primary production in many marine ecosystems. Traditionally, picoplankton refers to cells < or =2 microm. Here we extend the size range of the organisms considered to 3 microm, a threshold often used operationally in field studies. While the prokaryotic component of pico...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2008.00121.x
更新日期：2008-08-01 00:00:00
abstract：:Ribonuclease P is the endonuclease required for generating the mature tRNA 5'-end. The ribonucleoprotein character of this enzyme has now been proven in most organisms and organelles. Exceptions, however, are still the chloroplasts, plant nuclei and animal mitochondria where no associated RNAs have been detected to da...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.1999.tb00406.x
更新日期：1999-06-01 00:00:00
abstract：:Most bacteria pathogenic for humans have closely related nonpathogenic counterparts that live as saprophytes, commensals or even symbionts (mutualists) in similar or different habitats. The knowledge of how these bacteria adapt their metabolism to the preferred habitats is critical for our understanding of pathogenesi...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2011.00301.x
更新日期：2012-03-01 00:00:00
abstract：:This review concerns the issues involved in the industrial development of fed-batch culture processes with Saccharomyces cerevisiae strains producing heterologous proteins. Most of process development considerations with fed-batch recombinant cultures are linked to the reliability and reproducibility of the process fo...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.1994.tb00146.x
更新日期：1994-12-01 00:00:00
abstract：:Perhaps the biggest single task facing a bacterial cell is to divide into daughter cells that contain the normal complement of chromosomes. Recent technical and conceptual breakthroughs in bacterial cell biology, combined with the flood of genome sequence information and the excellent genetic tools in several model sy...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2000.tb00554.x
更新日期：2000-10-01 00:00:00
abstract：:A high level of anti-HCV is generally associated with viral replication and the number of recognized epitopes appears to be correlated with the viral charge. Nevertheless, the absence of detectable antibodies in about 60% of patients during the acute phase of the disease and in 10% of chronically infected (generally i...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章
doi：10.1111/j.1574-6976.1994.tb00092.x
更新日期：1994-07-01 00:00:00
abstract：:The species concept is a recurrent controversial issue that preoccupies philosophers as well as biologists of all disciplines. Prokaryotic species concept has its own history and results from a series of empirical improvements parallel to the development of the techniques of analysis. Among the microbial taxonomists, ...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.2001.tb00571.x
更新日期：2001-01-01 00:00:00
abstract：:The wealth of information existing on the general principle of S-layers has revealed a broad application potential. The most relevant features exploited in applied S-layer research are: (i) pores passing through S-layers show identical size and morphology and are in the range of ultrafiltration membranes; (ii) functio...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1574-6976.1997.tb00306.x
更新日期：1997-06-01 00:00:00
abstract：:The genus Rickettsia (Alphaproteobacteria, Rickettsiales, Rickettsiaceae) is comprised of obligate intracellular parasites, with virulent species of interest both as causes of emerging infectious diseases and for their potential deployment as bioterrorism agents. Currently, there are no effective commercially availabl...
journal_title：FEMS microbiology reviews
pub_type： 杂志文章,评审
doi：10.1111/1574-6976.12084
更新日期：2015-01-01 00:00:00
