Nickel uptake and utilization by microorganisms.

Abstract:

:Nickel is an essential nutrient for selected microorganisms where it participates in a variety of cellular processes. Many microbes are capable of sensing cellular nickel ion concentrations and taking up this nutrient via nickel-specific permeases or ATP-binding cassette-type transport systems. The metal ion is specifically incorporated into nickel-dependent enzymes, often via complex assembly processes requiring accessory proteins and additional non-protein components, in some cases accompanied by nucleotide triphosphate hydrolysis. To date, nine nickel-containing enzymes are known: urease, NiFe-hydrogenase, carbon monoxide dehydrogenase, acetyl-CoA decarbonylase/synthase, methyl coenzyme M reductase, certain superoxide dismutases, some glyoxylases, aci-reductone dioxygenase, and methylenediurease. Seven of these enzymes have been structurally characterized, revealing distinct metallocenter environments in each case.

journal_name

FEMS Microbiol Rev

authors

Mulrooney SB,Hausinger RP

doi

10.1016/S0168-6445(03)00042-1

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

239-61

issue

2-3

eissn

0168-6445

issn

1574-6976

pii

S0168644503000421

journal_volume

27

pub_type

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